Tag: 56-54-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56-54-2,(S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol,as a common compound, the synthetic route is as follows.

56-54-2, 4-Hydroxyphenylacetic acid (40 mg,0.263 mmol) and quinidine (85.3 mg, 0.263 mmol) were dissolved in ethanol, and after 2 weeks crystals were obtained. Similar crystals were obtained using methanol, isopropanol and tetrahydrofuranas solvents.

As the paragraph descriping shows that 56-54-2 is playing an increasingly important role.

Reference£º
Article; Amombo Noa, Francoise M.; Jacobs, Ayesha; Journal of Molecular Structure; vol. 1114; (2016); p. 30 – 37;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

56-54-2, General procedure: An oven-dried culture tube containing the tetrayne precursor in organic solvent (initial concentration of 0.02-0.03 M) and the indicated number of equivalents of trapping component(s) was closed with a Teflon-lined cap and the solution was heated at 85-90 C for 16 h. The half-life for conversion of each of the polyynes used here to the corresponding benzyne was approx. 3-4 h. The product(s) was separated and purified by chromatography on silica gel. Full experimental details and characterization data for all new compounds (polyyne HDDA substrates andproducts) and a description of the computational methods and results are providedin the Supplementary Information.

As the paragraph descriping shows that 56-54-2 is playing an increasingly important role.

Reference£º
Article; Ross, Sean P.; Hoye, Thomas R.; Nature Chemistry; vol. 9; 6; (2017); p. 523 – 530;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

56-54-2, General procedure: 4.24.12 N-(3,5-Ditrifluoromethyl)benzyl-6′-hydroxyquinidi-nium bromide (4c) Ethanethiol (2.30 mL, 30.8 mmol) was added under argon atmosphere to a stirred suspension of sodium hydride (370.0 mg, 15.4 mmol) in dry DMF (15 mL). Quinidine (500 mg, 1.5 mmol) in dry DMF (7.5 mL) was added dropwise and the reaction mixture was stirred at 110 C for 13 h. The solvent and excess ethanethiol were removed under reduced pressure. Then the 3,5-ditrifluoromethylbenzyl bromide (675.4 mg, 2.2 mmol) was added in THF (9 mL). The reaction mixture was refluxed and monitored by TLC analysis. The solvent was removed under reduced pressure and the residue was purified by flash chromatography (MeOH/EtOAc = 1/20, V/V). Yield 52%; white solid; mp 258 C (decomp.); [alpha]D28 +182.3 (c 0.16, CH3OH); IR (KBr): 3369, 3234, 1622, 1531, 1469, 1217, 1181, 1135, 1003, 927, 905, 864, 842, 736, 709, 683 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 10.06 (s, 1H), 8.75 (d, J = 4.4 Hz, 1H), 8.63 (s, 2H), 8.37 (s, 1H), 7.95 (d, J = 8.8 Hz, 1H), 7.70 (d, J = 4.4 Hz, 1H), 7.67 (d, J = 2.4 Hz, 1H), 7.38 (dd, J = 9.0, 2.2 Hz, 1H), 6.68 (d, J = 3.6 Hz, 1H), 6.32 (s, 1H), 6.02 (ddd, J = 17.4, 10.5, 6.9 Hz, 1H), 5.38 (d, J = 12.4 Hz, 1H), 5.26-5.19 (m, 3H), 4.32 (t, J = 9.6 Hz, 1H), 4.13 (t, J = 9.6 Hz, 1H), 3.92 (t, J = 9.6 Hz, 1H), 3.49 (t, J = 11.2 Hz, 1H), 3.12-3.05 (m, 1H), 2.65-2.59 (m, 1H), 2.33 (t, J = 11.6 Hz, 1H), 1.89 (s, 1H), 1.83-1.78 (m, 2H), 1.17-1.09 (m, 1H); 13C NMR (100 MHz, DMSO-d6): delta = 156.5, 147.2, 143.4, 143.1, 137.7, 135.2, 131.9, 131.7, 131.2 (q, J = 33.0 Hz), 126.1, 124.6 (q, J = 3.2 Hz), 123.7 (q, J = 271.8 Hz), 122.2, 120.4, 117.6, 105.1, 68.2, 65.3, 60.9, 56.3, 54.7, 37.3, 26.9, 23.6, 21.0; HRMS calcd for [C28H27F6N2O2]+: 537.1971, found 537.1959.

56-54-2 (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol 637552, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,56-54-2

Example 6 (S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid, Quinidine Salt (XXVIII) (rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid THF-solvate (XXVI) (555 g, 0.910 mol) was prepared at 20 C. in butyl acetate (2.22 l) and combined with (+)-quinidine (334.3 g; 1.03 mol). Heating was then done to 50 C. and stirring for 1 h at 50 C. After cooling to 5 C., filtering was done and the filter cake was stirred with butyl acetate (1.2 l), filtered again, and washed with butyl acetate (0.7 l). Drying was done at 40 C. in vacuum. Yield: 361 g (45% of theory) of a cream-colored solid. 1H-NMR (400 MHz, DMSO-d6): delta=1.58 (m, 2H), 1.79 (m, 1H), 2.04 (m, 1H), 2.07 (s, 3H), 2.33 (m, 1H), 2.77 (s, 3H), 2.79 (m, 1H), 2.90 (m, 2H), 3.21 (m, 1H), 3.33 (m, 2H), 3.51 (s, 3H), 3.90 (s, 3H), 5.11 (d, 1H), 5.14 (d, 1H), 5.53 (br. s, 1H), 6.09 (ddd, 1H), 6.72 (s, 1H), 7.75 (m, 2H), 7.82 (m, 1H), 7.92 (br. s, 1H), 8.11 (br. d, 1H), 8.27 (d, 1H), 8.46 (s, 1H), 12.75 (br. s, 1H).

56-54-2 (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol 637552, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; pH Pharma, Ltd.; Schirmer, Heiko; Rubenbauer, Philipp; Keil, Birgit; Olenik, Britta; (29 pag.)US2018/72685; (2018); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of quinine/quinidine 5 in dry DMF (4 mL/mmol 5) was treated with dry NaH (2.8 equiv.) and the resulting mixture was stirred at r.t. for 2 h. Benzyl chloride or allyl bromide (1.1 equiv.) were added and the resulting mixture was stirred at r.t. for 20 h. After extraction with brine and EtOAc the organic phase was dried over Na2SO4, filtrated and evaporated to dryness, giving 9-O-allylated or 9-O-benzylated compounds 6 [26] in >87% yield and sufficient purity for the following steps.

The synthetic route of 56-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Schoergenhumer, Johannes; Otte, Stefan; Haider, Victoria; Novacek, Johanna; Waser, Mario; Tetrahedron; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI