Tag: 7089-68-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7089-68-1,2-Chloro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

7089-68-1, A mixture of 150 mL of toluene, 4.28 g (20 mmol) of 2-chloro-1,10-phenanthroline and 1.03 g (120 mmol) piperazine were boiled up to the disappearance of original 2-chloro-1,10-phenanthroline. Control over the reaction course was carried out by means of TLC (chloroform :ethyl acetate = 1 : 1). Toluene was distilled off and the residue was dissolved in chloroform and chromatographed on silica gel, eluents?chloroform?ethyl acetate (1 : 1) and chloroform?ethanol (10 : 1).Yield 3.33 g (63percent). 1 NMR spectrum (CDCl3), delta,ppm: 9.04 d.d (1, H9, J = 4.3, 1.6 Hz), 8.08 d.d (1,H7, J = 8.1, 1.6 Hz), 7.90 d (1, H4, J = 9.1 Hz), 7.55d (1, H5, J = 8.5 Hz), 7.45 d.d (1, H8, J = 8.1,4.3 Hz), 7.41 d (1, H6, J = 8.6 Hz), 7.02 d (1, H3,J = 9.1 Hz), 3.90 t (4, H15, J =5.0 Hz), 2.98 t (4,H16, J = 5.0 Hz). 13C NMR spectrum (CDCl3), deltaC,ppm: 156.60 (C2), 148.52 (C9), 144.33 (C13), 144.26(C14), 137.25 (C4), 135.25 (C7), 128.57 (C12), 125.52(C5), 121.64 (C11), 121.53 (C6), 121.36 (C8), 108.76(C3), 43.59 (C15), 43.05 (C16).

As the paragraph descriping shows that 7089-68-1 is playing an increasingly important role.

Reference£º
Article; Kokina; Ustimenko, Yu. P.; Rakhmanova; Sheludyakova; Agafontsev; Plyusnin; Tkachev; Larionov; Russian Journal of General Chemistry; vol. 89; 1; (2019); p. 87 – 95; Zh. Obshch. Khim.; vol. 89; 1; (2019); p. 100 – 109,10;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7089-68-1,2-Chloro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.,7089-68-1

In the atmosphere of nitrogen, intermediate A2 (1.6g, 5.6 mmol), 2-chlorophenanthroline (0.8g, 3.7 mmol), tetrakis(triphenylphosphine)palladium (0) (0.1g, 0.11 mmol), cesium carbonate (3.0g, 9.3 mmol) and 1,2-dimethoxyethane (37 mL) were mixed, followed by stirring at 80¡ãC for 6 hours. Water (50 mL) was added to the reaction mixture, and the precipitates were filtered out to obtain a yellow solid (compound (2-A); 0.76g, 60percent).1H-NMR (400MHz, CDCl3, TMS)delta: 3.25 (s,3H), 7.70 (d,J8.0,1H), 8.03 (d,J8.0,1H), 8.18 (d,J8.0,1H), 8.30 (d,J8.0,1 H), 8.41 (d,J8.0,1H), 8.69 (s,1H), 8.83 (d,J8.0,1 H), 9.26 (d,J8.0,1H).

The synthetic route of 7089-68-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Idemitsu Kosan Co., Ltd.; YASUKAWA, Keiichi; MAEDA, Ryoji; TOKAILIN, Hiroshi; EP2599780; (2013); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI