Tag: M.W:100-200

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4730-54-5

Amixture of 17 (0.448 g, 2.24 mmol), potassium carbonate (0.41 g,3.0 mmol) and TACN (0.095 g, 0.74 mmol) in acetonitrile (20 mL) wasrefluxed overnight. The mixture was then added to water (50 mL) beforeextraction with dichloromethane (3 ¡Á 50 mL). The organic extractswere washed with brine (50 mL) before being dried with magnesiumsulfate and the solvent removed in vacuo to yield a dark orange highlyviscous liquid (0.431 g, 93%). deltaH (400 MHz; CDCl3; Me4Si) 2.87 (12H,s) 3.72 (6H, s) 4.79 (6H, d, J 6.4 Hz) 5.38 (6H, m) 6.05 (3H, m) 6.15(3H, dd, J 1.4, 6.9 Hz) 6.56 (3H, dd, J 1.4, 9.2 Hz) 7.24 (3H, dd, J 6.9,9.2 Hz); deltaC (100 MHz) 55.9, 57.1, 76.7, 104.8, 120.4, 122.1, 130.5,137.9, 147.7, 159.7; (+)-ESI-MS:m/z 619.05 (M+H+); NESI: requires;m/z 619.3244, found; 619.3243 (M + H+).

4730-54-5 1,4,7-Triazacyclononane 188318, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Workman, David G.; Hunter, Michael; Dover, Lynn G.; Tetard, David; Journal of Inorganic Biochemistry; vol. 160; (2016); p. 49 – 58;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Di-tert-butyl dicarbonate (Boc2O, 5.1 g, 23.2 mmol) in anhydrous trichloromethane (30 mL) was added dropwise to a stirred solution of TACN (2.0 g, 15.5 mmol) and triethylamine (4.7 mL, 3.1 g, 31.0 mmol) in anhydrous trichloromethane (100 mL). The resulting reaction mixture was stirred for 24 h at room temperature. Excess triethylamine was removed by washing the reaction mixture with water (3 ¡Á 50 mL) and brine (2 ¡Á 50 mL). The organic layer was collected and dried over anhydrous magnesium sulfate and then filtered. The solvent was evaporated under reduced pressure to give the crude products which were purified by chromatography over silica (EtOAc(EA)/Petroleum ether(PE), 1 : 1, v/v) as colorless oil 2Boc-TACN (1) (Rf = 0.5, EA).

4730-54-5, The synthetic route of 4730-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Bing; Yi, Wen-Jing; Zhang, Ji; Zhang, Qin-Fang; Xun, Miao-Miao; Yu, Xiao-Qi; Bioorganic and Medicinal Chemistry Letters; vol. 24; 7; (2014); p. 1771 – 1775;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4730-54-5

Solid 1,3,5-triazacyclononane (16 mg, 0.12 mmol) was added to an aqueous solution of freshly prepared [Cp*Ir(H2O)3]SO4 (0.1 mmol in 5 mL). The yellow solution was stirred for 16 hours at room temperature and then taken to dryness under reduced pressure. The solid residue was taken up in 2 mL of dry methanol and the solution filtered through 0.2 mum pore size Teflon filter. Addition of 12 mL Et2O caused precipitation of a fine solid, and after taking off the pale yellow supernatant a colorless powder remained which was dried in vacuo. Yield 43 mg (78%). 1H-NMR (400 MHz, D2O): delta=3.09 (m, 6H), 2.95 (m, 6H), 1.81 (s, 15H). 13C-NMR (126 MHz, D2O): delta=88.1, 52.2, 7.8.

4730-54-5 1,4,7-Triazacyclononane 188318, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Sheehan, Stafford Wheeler; Hintermair, Ulrich; Thomsen, Julianne M.; Brudvig, Gary W.; Crabtree, Robert H.; US2015/21194; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56100-20-0,5-Methyl-2,2′-bipyridine,as a common compound, the synthetic route is as follows.,56100-20-0

To a mixture of dry diisopropylamine (1.0 mL, 7.1 mmol) and dry THF (50 mL) was added dropwise n-butyllithium (1.6 M hexane solution, 3.8 mL, 6.1 mmol) at -78 C under a nitrogen atmosphere. The solution was stirred for 30 min and 6 (681 mg, 4.00 mmol) in dry THF (15 mL) was added at -78 C. The solution was stirred for 1 h and 1,4-dibromobutane (4.32 g, 20.0mmol) in dry THF (15 mL) was added. The solution was allowed to warm up to room temperature and stirred overnight. The reaction mixture was washed with aqueous sodium hydrogen carbonate and brine. The solution was dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was separated by column chromatography on aluminium oxide (hexane/dichloromethane = 3/1 (v/v)) to give 7 as a white solid (964 mg, 79%). 7: mp 31 C; 1H NMR (300 MHz,CDCl3): 8.67 (d, 1H, J = 4.8 Hz), 8.51 (d, 1H, J = 2.1 Hz), 8.36 (d, 1H, J = 8.0 Hz), 8.31 (d, 1H, J = 8.1 Hz), 7.81 (td,1H, J = 7.7, 1.6 Hz), 7.64 (dd, 1H, J = 8.1, 2.0 Hz), 7.31-7.29 (m, 1H), 3.41 (t, 2H, J = 6.7 Hz), 2.70 (t, 2H, J = 7.6 Hz), 1.91 (quintet, 2H, J = 7.1 Hz), 1.70 (quintet, 2H, J = 7.6 Hz), 1.57-1.49 (m, 2H); 13C NMR (75 MHz, CDCl3): 156.2, 154.0,149.3, 149.2, 137.7, 136.9, 136.8, 123.5, 120.8, 120.7, 33.6,32.7, 32.5, 30.2, 27.7; MS (EI+): m/z 304 [M+]; IR (KBr,cm-1): 3067(m), 3053(m), 3011(m), 2962(m), 2943(s), 2928(s), 2866(s), 1585(s), 1574(m), 1557(s), 1460(s), 1429(s), 1392(m), 1350(w), 1304(w), 1258(m), 1230(m), 1205(m), 1190(w), 1148(w), 1092(w), 1065(w), 1042(w), 1030(m), 1013(m), 991(m), 860(s), 808(m), 785(s), 752(s), 737(m), 727(m), 640(s), 606(s); HRMS (EI+): m/z calcd for C15H1779BrN2 [M+]: 304.0575; found: 304.0577.

56100-20-0 5-Methyl-2,2′-bipyridine 11073848, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Ninomiya, Yoshikazu; Kozaki, Masatoshi; Suzuki, Shuichi; Okada, Keiji; Bulletin of the Chemical Society of Japan; vol. 87; 11; (2014); p. 1195 – 1201;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1126-58-5, 1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a magnetically stirred solution of substituted isatin (5mmol) in 7ml of absolute ethanol, a corresponding pyridinium acetohydrazide (5mmol) and three drops of trifluoroacetic acid were successively added. The reaction mixture was heated under reflux for 3h. After spontaneously cooling the solution to room temperature, the precipitate formed was filtered, washed with absolute ether and dried in vacuo.

1126-58-5, 1126-58-5 1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium chloride 70773, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Bogdanov, Andrei V.; Zaripova, Ilyuza F.; Voloshina, Alexandra D.; Sapunova, Anastasia S.; Kulik, Natalia V.; Tsivunina, Irina V.; Dobrynin, Alexey B.; Mironov, Vladimir F.; Journal of Fluorine Chemistry; vol. 227; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14162-94-8,4-Chloro-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: For compound 1, a 1.0 mL aqueous solution of Ni(ClO4)2¡¤6H2O (0.005mmol) was placed at the bottom of a tube, a mixture of methanol and water (1:2, v/v, 3 mL)was gently layered on the top of the solution, and then a 1.0 mL methanol solutionof Bu4N[Fe(Tp*)(CN)3] (0.005 mmol) and 4-chlorine-2,2?-dibipyridine (0.01 mmol)was carefully added as the top layer. After few weeks, red block crystals were obtained,washed with water and air dried.

14162-94-8, The synthetic route of 14162-94-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jiao, Yu-Shu; Jiao, Cheng-Qi; Meng, Yin-Shan; Liu, Xue-Ru; Zhao, Liang; Liu, Tao; Inorganic Chemistry Communications; vol. 93; (2018); p. 87 – 91;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

62937-45-5,62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D-Prolinamide (42.8 mg, 375 muiotaetaomicron) and N,N-diisopropylethylamine (65 mu, 380 mumol) were added to a solution of 2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5- dihydro-lH-l,2,4-triazol-l-yl}methyl)-lH-l,2,4-triazol-l-yl]benzoyl chloride (Example 58A, 79.1 mg, 150 muiotaetaomicron) in tetrahydrofuran (2.3 ml). This reaction mixture was stirred for 1 h at room temperature. The crude product was purified by preparative HPLC (Method 4). Lyophihsation of the product containing fractions afforded 53.9 mg (57 % of th.) of the title compound. LC-MS (Method 2): Rt = 1.53 min; MS (ESIpos): m/z = 605 [M+H]+ -NMR (400 MHz, DMSO-d6) delta [ppm]: -0.215 (1.05), -0.008 (3.93), 0.008 (3.02), 0.716 (3.19), 1.701 (2.80), 1.716 (2.72), 1.742 (2.33), 1.759 (3.07), 1.776 (3.57), 1.787 (3.15), 1.798 (2.94), 1.812 (1.93), 2.053 (1.59), 2.073 (1.94), 2.709 (0.57), 3.205 (1.74), 3.231 (1.37), 3.247 (2.09), 3.287 (4.72), 3.373 (0.82), 3.441 (1.05), 3.816 (1.83), 3.824 (1.18), 3.840 (2.10), 3.852 (2.94), 3.860 (1.87), 3.877 (2.98), 3.884 (2.00), 3.974 (4.06), 3.982 (4.47), 4.010 (2.84), 4.019 (2.68), 4.217 (1.80), 4.229 (1.82), 4.309 (2.20), 5.021 (1.30), 5.061 (14.55), 5.069 (10.76), 5.109 (1.19), 6.913 (3.15), 6.928 (5.00), 6.958 (4.94), 6.973 (4.86), 7.064 (3.77), 7.297 (2.31), 7.342 (3.89), 7.411 (1.12), 7.472 (1.37), 7.492 (2.44), 7.509 (1.27), 7.539 (1.39), 7.556 (3.82), 7.577 (3.93), 7.601 (12.46), 7.614 (6.91), 7.617 (8.60), 7.622 (16.00), 7.629 (8.66), 7.635 (11.09), 7.648 (3.33), 7.676 (3.24), 7.696 (2.26), 7.723 (5.02), 7.745 (10.67), 7.752 (12.89), 7.767 (6.68), 7.773 (9.27), 8.933 (10.76).

As the paragraph descriping shows that 62937-45-5 is playing an increasingly important role.

Reference£º
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; COLLIN-KROePELIN, Marie-Pierre; KOLKHOF, Peter; NEUBAUER, Thomas; FUeRSTNER, Chantal; POOK, Elisabeth; WITTWER, Matthias, Beat; LUSTIG, Klemens; TINEL, Hanna; LINDNER, Niels; SCHIRMER, Heiko; (449 pag.)WO2019/81307; (2019); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

54258-41-2,54258-41-2, 1,10-Phenanthrolin-5-amine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Both compounds were synthesized in the same way. A mixture ofthe appropriate aldehyde [thiophene-2,5-dicarbaldehyde (283 mg,2.02 mmol), furan-2,5-dicarbaldehyde (316 mg, 2.55 mmol)] and5-amino-1,10-phenanthroline [(1091 mg, 5.59 mmol) withthiophene-2,5-dicarbaldehyde, (1458 mg, 7.48 mmol) with furan-2,5-dicarbaldehyde] was refluxed in EtOH (50 mL) containing acatalytic amount of acetic acid for 12 h, giving a suspension. Thereaction mixture was filtered hot, and the solid was washed withEtOH to afford the desired product as a yellow solid.

As the paragraph descriping shows that 54258-41-2 is playing an increasingly important role.

Reference£º
Article; Cheng, Feixiang; He, Chixian; Yu, Shiwen; Yin, Hongju; Inorganica Chimica Acta; vol. 462; (2017); p. 43 – 49;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4730-54-5,1,4,7-Triazacyclononane,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 1,4,7-triazacyclononane (2 mmol) in distilled ethanol (50 mL) containing molecular sieve was added 1 equiv of aldehyde. The reaction mixture was stirred at room temperature. The solution was filtered and the filtrate was evaporated under reduced pressure to yield the aminal adduct., 4730-54-5

As the paragraph descriping shows that 4730-54-5 is playing an increasingly important role.

Reference£º
Article; Roger, Melissa; Patinec, Veronique; Bourgeois, Martine; Tripier, Raphael; Triki, Smail; Handel, Henri; Tetrahedron; vol. 68; 27-28; (2012); p. 5637 – 5643;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

294-90-6, 1,4,7,10-Tetraazacyclododecane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of di-te/t-butyl dicarbonate (6.08 g, 27.8 mmol) in anhydrous CH2CI2 (100 ml) was added dropwise to a stirred solution of cyclen (2.00 g, 11.61 mmol) in anhydrous CH2CI2 (300 ml). The reaction mixture was stirred at room temperature, for 18 h. The solvent was removed under reduced pressure to afford a transparent oil. The crude material was purified by column chromatography on silica (gradient elution: CH2CI2 to 5 % CH3OH : CH2CI2, utilising 0.1 % CH3OH increments) to yield the title compound 17 as a colourless crystalline solid (3.08 g, 6.51 mmol, 56 %); RF = 0.29 (Silica, CH2CI2 – CH3OH, 9 : 1, v/v); 1H NMR (CDCI3, 500 MHz) delta 1.42 (18H, s, feoc CH3), 1.44 (9H, s, *Boc CH3), 2.81 (4H, br s, cyclen CH2), 3.28 (8H, br s, cyclen CH2), 3.60 (4H, br s, cyclen CH2); 13C NMR (CDCI3, 125 MHz, 1H decoupled 500 MHz) delta 28.9 (6C, ‘Boc CH3), 29.0 (3C, ‘Boc CH3), 46.1 (2C, cyclen CH2), 49.9 (2C, cyclen CH2), 51.2 (4C, cyclen CH2), 79.4 (2C, fex*,)), 79.6 (1C, ^oqq)), 155.8 (2C, feoc C = O), 156.0 (1C, ‘Boc C = O); MS (ES+) m/z 473.3 (100 %, [M + H]+); HRMS (ES+) m/z found 473.3330 [M + H]+ C23H45O6N4 requires 473.3333., 294-90-6

The synthetic route of 294-90-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CIS BIO INTERNATIONAL; LAMARQUE, Laurent; MONTGOMERY, Craig; PARKER, David; WO2010/84090; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI