Tag: M.W:100-200

4730-54-5, 1,4,7-Triazacyclononane is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of a LiOEt in THF (1.0M, 2.0mL) was added dropwise to a solution of TACN (201mg, 1.56mmol) in THF (20mL), and stirred at 0C under argon. After 10min, a solution of 9 (772mg, 1.56mmol) was added dropwise at 0C, and the mixture was stirred at room temperature for 12h. The mixture was then diluted with 2¡Á50mL of ethyl acetate and dried over MgSO4. The solvent was removed under reduced pressure, and the residue was purified by flash column chromatography (Al2O3, CHCl3) to give 620mg (0.452mmol, 29%) of 10 as a white solid. 1H NMR (400MHz, CDCl3) delta (ppm): 2.76-2.79 (q, 6H); 2.83 (s, 12H); 3.12-3.14 (q, 6H); 3.53-3.56 (q, 3H); 3.57 (s, 6H); 3.61-3.75 (q, 3H); 3.83-3.85 (q, 6H); 4.35-4.38 (d, 2H); 4.47-4.59 (m, 12H); 7.21-7.32 (m, 36H). 13C NMR (100MHz, CDCl3) delta (ppm): 51.2, 52.2, 55.4, 62.7, 70.3, 73.0, 74.9, 80.6, 125.5, 126.9, 127.7, 127.8, 129.1, 136.8, 137.6, 138.5, 138.6, 140.3. ESI TOF MS: m/z [M+H]+ calcd for 1372.6832, found 1372.6834.

4730-54-5, The synthetic route of 4730-54-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Miyake, Yuka; Kimura, Yu; Orito, Naomi; Imai, Hirohiko; Matsuda, Tetsuya; Toshimitsu, Akio; Kondo, Teruyuki; Tetrahedron; vol. 71; 26-27; (2015); p. 4438 – 4444;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13040-77-2,6-Chloro-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

The reaction was performed under argon. Substituted azole (excess) and potassium tert-butoxide were dissolved at RT in dry and degassed DMSO. An exothermic reaction occurred. The mixture was stirred for 10 min to allow the reaction to finish and cool. Then, a substituted halopyridine was added. The reaction mixture was stirred for 24 h at 140C to give a suspension. It was cooled to RT. Water (50mL) was added: the product precipitated on stirring/sonication. The solid was filtered, washed with water, and extracted with dichloromethane and water. The organic layer was washed with water to extract DMSO. Purification by chromatography on silica (20g) removed the starting materials and by-products on elution with 0-0.4% CH3OH in CH2Cl2, and provided the pure product on elution with 0.4-1.0% CH3OH in CH2Cl2. Anal. Calc. for C14H12N4 (MW 236.27): C, 71.17; H, 5.12; N, 23.71. Found: C, 71.44; H, 5.10; N, 24.05%., 13040-77-2

The synthetic route of 13040-77-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shavaleev, Nail M.; Kessler, Florian; Graetzel, Michael; Nazeeruddin, Mohammad K.; Inorganica Chimica Acta; vol. 407; (2013); p. 261 – 268;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI