Tag: M.W:200-300

Computed Properties of C6H12ClN3O3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: DL-Histidine monohydrochloride monohydrate, is researched, Molecular C6H12ClN3O3, CAS is 123333-71-1, about Molecular docking and dynamic studies of different Histidine derivatives as HDAC2 inhibitors. Author is Ramakrishnan, Geetha; Kandakatla, Naresh.

Histone deacetylases 2 (HDAC2) proteins belongs to Class I histone deacetylase (HDAC) family and an important target for the treatment of different types of cancer. Of the various HDAC2 inhibitors, our earlier investigations proved that presence of histidine moiety yielded better clin. results. The search of histidine containing compounds is done extensively which yielded a total of 1284 hit compounds The chosen compounds were subjected to mol. docking in the active site of HDAC2 (PDB: 3MAX) and screening done based on Lipinski rule of 5, resulted in twenty hit compounds as novel potential HDAC2 inhibitors. The careful anal. of the investigation gave the compound ZINC13282319-(2S)-2-(3-aminopropanamido)-3-(3H-imidazol-4-yl)propanoic acid as the most promising compound based on the docking score and hydrogen bond interaction. The best possible interactions of the lead compounds are simulated for stability using mol. dynamics. The results of this investigation provide valuable information on the design of highly selective histidine derivatives

There is still a lot of research devoted to this compound(SMILES：O=C(O)C(N)CC1=CNC=N1.[H]Cl.[H]O[H])Computed Properties of C6H12ClN3O3, and with the development of science, more effects of this compound(123333-71-1) can be discovered.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2834-05-1, is researched, SMILESS is O=C(O)CCCCCCCCCCBr, Molecular C11H21BrO2Journal, New Journal of Chemistry called A cholesterol based imidazolium ionic liquid crystal: synthesis, characterisation and its dual application as an electrolyte and electrode material, Author is Mangaiyarkarasi, R.; Selvam, S.; Ganesh, V.; Umadevi, S., the main research direction is cholesterol imidazolium ionic liquid crystal preparation electrolyte electrode.Category: catalyst-ligand.

A new ionic liquid crystal (ILC) containing cholesterol and bearing a terminal imidazolium moiety was synthesized and its mesophase behavior was investigated by polarizing optical microscopy (POM), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) studies. The ILC displayed an intercalated lamellar mesophase having a wide phase range. Cyclic voltammetry studies of the synthesized ILC revealed electrochem. stability with a good electrochem. window. Further, the electrochem. performance of the ILC was evaluated as an electrolyte (0.5% in ethanol) for supercapacitor applications using a three electrode system consisting of a graphene oxide-manganese dioxide (100 μm) coated carbon fiber electrode, silver-silver chloride (Ag-AgCl) reference and platinum foil counter electrodes. Among three different ratios of graphene oxide-manganese dioxide (1 : 1, 1 : 0.5, and 0.5 : 1) investigated, the electrode containing 0.5 : 1 wt% graphene oxide-manganese dioxide over carbon fiber showed good capacitive behavior with a specific capacitance of 157.5 F g-1 at a constant c.d. of 0.5 A g-1 along with a good cyclic stability. In addition, the ILC was also studied as an electrode material in combination with carbon paste for investigating electron transfer reactions.

There is still a lot of research devoted to this compound(SMILES：O=C(O)CCCCCCCCCCBr)Category: catalyst-ligand, and with the development of science, more effects of this compound(2834-05-1) can be discovered.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Huang, Fei; Zhang, Songlin researched the compound: 11-Bromoundecanoic acid( cas:2834-05-1 ).Recommanded Product: 11-Bromoundecanoic acid.They published the article 《Iminyl Radicals by Reductive Cleavage of N-O Bond in Oxime Ether Promoted by SmI2: A Straightforward Synthesis of Five-Membered Cyclic Imines》 about this compound( cas:2834-05-1 ) in Organic Letters. Keywords: oxime iminyl radical reductive bond cleavage cyclization samarium iodide; five membered cyclic imine preparation. We’ll tell you more about this compound (cas:2834-05-1).

A new generation method of N-centered radicals from the reductive cleavage of the N-O bond in oxime ether promoted by SmI2 is reported for the first time. The in-situ-generated N-centered radicals underwent intramol. cyclization to afford five-membered cyclic imines in two manners: N-centered radical addition and N-centered anion nucleophilic substitution. From a synthetic point of view, an efficient synthetic method of five-membered cyclic imines was developed. A mechanism of the transformation was proposed.

Here is a brief introduction to this compound(2834-05-1)Recommanded Product: 11-Bromoundecanoic acid, if you want to know about other compounds related to this compound(2834-05-1), you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, ACS Nano called Supramolecular Chirality Synchronization in Thin Films of Plasmonic Nanocomposites, Author is Szustakiewicz, Piotr; Kowalska, Natalia; Grzelak, Dorota; Narushima, Tetsuya; Gora, Monika; Baginski, Maciej; Pociecha, Damian; Okamoto, Hiromi; Liz-Marzan, Luis M.; Lewandowski, Wiktor, which mentions a compound: 2834-05-1, SMILESS is O=C(O)CCCCCCCCCCBr, Molecular C11H21BrO2, HPLC of Formula: 2834-05-1.

Mirror symmetry breaking in materials is a fascinating phenomenon that has practical implications for various optoelectronic technologies. Chiral plasmonic materials are particularly appealing due to their strong and specific interactions with light. In this work, we broaden the portfolio of available strategies toward the preparation of chiral plasmonic assemblies, by applying the principles of chirality synchronization-a phenomenon known for small mols., which results in the formation of chiral domains from transiently chiral mols. We report the controlled cocrystn. of 23 nm gold nanoparticles and liquid crystal mols. yielding domains made of highly ordered, helical nanofibers, preferentially twisted to the right or to the left within each domain. We confirmed that such micrometer sized domains exhibit strong, far-field CD (CD) signals, even though the bulk material is racemic. We further highlight the potential of the proposed approach to realize chiral plasmonic thin films by using a mech. chirality discrimination method. Toward this end, we developed a rapid CD imaging technique based on the use of polarized light optical microscopy (POM), which enabled probing the CD signal with micrometer-scale resolution, despite of linear dichroism and birefringence in the sample. The developed methodol. allows us to extend intrinsically local effects of chiral synchronization to the macroscopic scale, thereby broadening the available tools for chirality manipulation in chiral plasmonic systems.

Here is a brief introduction to this compound(2834-05-1)HPLC of Formula: 2834-05-1, if you want to know about other compounds related to this compound(2834-05-1), you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Probing the interaction of nanoparticles with small molecules in real time via quartz crystal microbalance monitoring.HPLC of Formula: 2834-05-1.

Despite extensive advances in the field of mol. recognition, the real-time monitoring of small mol. binding to nanoparticles (NP) remains a challenge. To this end, we report on a versatile approach, based on quartz crystal microbalance with dissipation monitoring, for the stepwise in situ quantification of gold nanoparticle (AuNPs) immobilization and subsequent uptake and release of binding partners. AuNPs stabilized by thiol-bound ligand shells of prescribed chem. composition were densely immobilized onto gold surfaces via dithiol linkers. The boronate ester formation between salicylic acid derivatives in solution and boronic acids in the AuNP ligand shell was then studied in real time, revealing a drastic effect of both ligand architecture and Lewis base concentration on the interaction strength. The binding kinetics were analyzed with frequency response modeling for a thorough comparison of binding parameters including relaxation time as well as association rate constant The results directly mirror those from previously reported in-depth studies using NMR spectroscopy. By achieving quant. characterization of selective binding of analytes with mol. weight below 300 Da, this new method enables rapid, low cost, rational screening of AuNP candidates for mol. recognition.

Here is a brief introduction to this compound(2834-05-1)HPLC of Formula: 2834-05-1, if you want to know about other compounds related to this compound(2834-05-1), you can read my other articles.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1148-79-4,2,2′:6′,2”-Terpyridine,as a common compound, the synthetic route is as follows.

Solid [Co(H2O)6](ClO4)2 (10.0 mg, 21.8 lmol) was placed at thebottom of a 4.0 cm3 test tube with 0.50 cm3 of dmso. Then the tubewas slowly filled with 2.50 cm3 of a dmso?CH3OH mixture (1:4 v/v)containing terpy (15.0 mg, 64.4 lmol). Finally, 1 (15.0 mg,9.01 lmol) dissolved in 0.50 cm3 of CH3OH was placed on the topand the tube covered with parafilm. X-ray quality deep browncrystals of 2 were grown in the text tube by slow diffusion at roomtemperature during 25 days. Yield: 3.20 mg (1.30 lmol, 29percent). X-rayabsorption microanalysis for 2: 3:2 Co/Nb molar ratio. Elementalanalysis for C105H86N18O33Co3Nb2 (2490.52 g mol1) ? Exp. (Calc.):percentC 51.55 (50.94), percentH 3.02 (3.18), percentN 10.49 (10.32), percentCo 7.50 (7.30)percent.IR (KBr disk/cm1): 3475 [m(O?H)], 3062 and 2930 [m(C?H)], 1715and 1687 [mas(CO)], 1641 [m(CN)], 1470 and 1448 [m(CC)],1401 [ms(CO)], 905 [m(NbO] and 421 [m(CoAN)].

1148-79-4, The synthetic route of 1148-79-4 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Oliveira, Willian X.C.; Pereira, Cynthia L.M.; Pinheiro, Carlos B.; Krambrock, Klaus; Grancha, Thais; Moliner, Nicolas; Lloret, Francesc; Julve, Miguel; Polyhedron; vol. 117; (2016); p. 710 – 717;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

22348-32-9, (R)-Diphenyl(pyrrolidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3A. Preparation of TMS-prolinolTo a mixture of prolinol (10.0 g, 39.5 mmol) and imidazole (4.57 g, 67.1 mmol) in THF (100 mL) was added chlorotrimethylsilane (5.57 g, 51.3 mmol) over 15 min while maintaining the batch temperature below 30 0C. The resulting slurry was aged at 50 0C for 3-5 h. The reaction mixture was cooled to ambient tempearture and quenched by addition of MTBE (50 mL) and 15% aq NaCl (100 mL). The organic layer was washed with 15% aq NaCl (50 mL). The solution was azeotropically dried at the constant volume by feeding THF.HPLC MethodColumn: Ascentis Express Cl 8 (100×4.6mm, 2.7um)Column temperature: 45 0CFlow rate: 1.5 ml/minDetection: UV at 210nmGradient:Time(min) 0.1% H^PO4 (0A) MeCN (0A)0 95 51 95 512 10 90Retention times (minutes): prolinol (4.8 min); TMS prolinol (7.3 min), 22348-32-9

The synthetic route of 22348-32-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SHARP &; DOHME CORP.; XU, Feng; DESMOND, Richard; HOERRNER, R. Scott; HUMPHREY, Guy, R.; ITOH, Tetsuji; JOURNET, Michel; YOSHIKAWA, Naoki; ZACUTO, Michael, J.; WO2010/144293; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71071-46-0,Dimethyl [2,2′-bipyridine]-4,4′-dicarboxylate,as a common compound, the synthetic route is as follows.

71071-46-0, General procedure: A solution of cis-RuII(bpz)2Cl2 (100 mg, 0.205 mmol) and AgNO3 (77 mg, 0.453 mol) in water (25 mL) was heated at reflux for 48 h. After cooling to room temperature, the mixture was filtered through Celite to remove AgCl, and the filtrate was evaporated to dryness. The residue was dissolved in DMF (15 mL) and the solution purged with argon for 15 min. 4,4?-bis(trifluoromethyl)-2,2?-bipyridyl (121 mg, 0.414 mmol) was added and the mixture heated at 100 °C for 24 h under argon. After cooling to room temperature, the solution was evaporated under vacuum to a small volume and diethyl ether (150 mL) added. The precipitate was filtered off and dissolved in a minimum of cold water to which solid NH4PF6 was added. The solid was filtered off and purified by column chromatography as for 1 to give an orange solid. Yield: 73 mg (35percent).

The synthetic route of 71071-46-0 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Coe, Benjamin J.; Peers, Martyn K.; Scrutton, Nigel S.; Polyhedron; vol. 96; (2015); p. 57 – 65;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

27318-90-7, 1,10-Phenanthroline-5,6-dione is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution containing 1,10-phenanthroline-5,6-dione (1.6 mmol, 347 mg), substituted benzaldehyde (1.6 mmol), 20 ml of HAc and NH4Ac (33 mmol, 2.53 g), was heated at 110 °C under reflux for 4 h. Then, 20 ml of water was added and the pH value was adjusted to 7.0 at room temperature. The solution was filtered and dried in vacuum to obtain a yellow precipitate. The product was purified in a silica gel column by using ethanol as eluent. 1a: yield 78.4percent; mp. 217-219 °C, ESI-MS (in MeOH): m/z: 219.1, ([M + H]), 438.1,([M + 2H]2+). 2a: yield 79.5percent; mp. 226-228 °C, ESI-MS (in MeOH): m/z: 339.15, ([M + H]+), 678.1, ([M + 2H]2+). 3a: yield 64.4percent; mp. 262-265 °C, ESI-MS (in MeOH): m/z: 325.1, ([M + H]+), 650.3, ([M + 2H]2+). 4a: yield 75.7percent; mp. 234-236 °C, ESI-MS (in MeOH): m/z: 311.1, ([M + H]+). 5a: yield 67.1percent; mp. 232-235 °C, ESI-MS (in MeOH): m/z: 339.1, ([M + H]+). 6a: yield 67.7percent; mp. 280-283 °C, ESI-MS (in MeOH): m/z: 363.1, ([M + H]+), 726.1, ([M + 2H]2+). 7a: yield 63.4percent; mp. 269-273 °C, ESI-MS (in MeOH): m/z: 375.2, ([M + H]+), 750, ([M 2H]2+), 772.8, ([M + H + Na]2+).

27318-90-7, 27318-90-7 1,10-Phenanthroline-5,6-dione 72810, acatalyst-ligand compound, is more and more widely used in various fields.

Reference：
Article; Wu, Qiong; Fan, Cundong; Chen, Tianfeng; Liu, Chaoran; Mei, Wenjie; Chen, Sidong; Wang, Baoguo; Chen, Yunyun; Zheng, Wenjie; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 57 – 63;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1148-79-4, 2,2′:6′,2”-Terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

UO2Cl2(terpy) (3): A mixture of 1.7 ml (0.2 mmol) UCl4/HCl 0.12 M, 93 mg (0.4 mmol) 2,2???:6???,2???-terpyridine, 2.3 ml (19 mmol) acetonitrile and 1.1 ml (12 mmol) pyridine was placed in a Parr vessel and then heated statically at 120 ?°C for 48 h. The resulting yellow product was then filtered off, washed with water and dried at room temperature (reaction yield 79percent). XRD powder pattern indicated that the compound was obtained as a pure phase (Supplementary Information S3)., 1148-79-4

As the paragraph descriping shows that 1148-79-4 is playing an increasingly important role.

Reference：
Article; Lhoste, Jerome; Henry, Natacha; Loiseau, Thierry; Guyot, Yannick; Abraham, Francis; Polyhedron; vol. 50; 1; (2013); p. 321 – 327;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI