Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15862-19-8,5-Bromo-2,2′-bipyridine,as a common compound, the synthetic route is as follows.,15862-19-8

5-bromo-2,2-bipyridine (0.480 g, 2 mmol), 2-methylthiophene (0.401 g, 4 mmol) and KOAc (0.401 g, 4 mmol) in dryDMA (5 mL) were stirred under N2 at 150 C for 20 h in thepresence of Pd(OAc)2 (0.009 g, 2 mol%). After cooling the solution to room temperature, CH2Cl2 (15 mL) and an aqueoussaturated NH4Cl solution (10 mL) were added. The reactionsolution was extracted three times with 15 mL of CH2Cl2, andthe combined organic layers were washed three times with 10mL of water. The solvent was evaporated under reduced pressure, and the crude product was purified by using columnchromatography (silica; 5:1 v/v hexane:EtOAc) to afford compound 1 in 22% yield (111 mg). 1H NMR (CDCl3, 500 MHz): 8.89 (dd, 1H, J = 2.3 and 0.6 Hz, ArH), 8.68 (ddd, 1H, J = 4.7,1.7 and 0.8 Hz, ArH), 8.448.36 (m, 2H, ArH), 7.93 (dd, 1H,J = 8.3 and 2.4 Hz, ArH), 7.82 (td, 1H, J = 7.8 and 1.8 Hz,ArH), 7.30 (ddd, 1H, J = 7.4, 4.8 and 1.1 Hz, ArH), 7.24(d, 1H, J = 3.5 Hz, ArH), 6.826.77 (m, 1H, ArH), 2.54 (s,3H, ArCH3) ppm. HR-MS (ESI+) m/z [M + H]+ calcd. for[C15H13N2S]+ 253.0799; found: 253.0803.

As the paragraph descriping shows that 15862-19-8 is playing an increasingly important role.

Reference：
Article; Kamila, Mritunjoy; Cosquer, Goulven; Breedlove, Brian K.; Yamashita, Masahiro; Bulletin of the Chemical Society of Japan; vol. 90; 5; (2017); p. 595 – 603;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15862-19-8,5-Bromo-2,2′-bipyridine,as a common compound, the synthetic route is as follows.,15862-19-8

5-bromo-2,2-bipyridine (0.480 g, 2 mmol), 2-methylthiophene (0.401 g, 4 mmol) and KOAc (0.401 g, 4 mmol) in dryDMA (5 mL) were stirred under N2 at 150 C for 20 h in thepresence of Pd(OAc)2 (0.009 g, 2 mol%). After cooling the solution to room temperature, CH2Cl2 (15 mL) and an aqueoussaturated NH4Cl solution (10 mL) were added. The reactionsolution was extracted three times with 15 mL of CH2Cl2, andthe combined organic layers were washed three times with 10mL of water. The solvent was evaporated under reduced pressure, and the crude product was purified by using columnchromatography (silica; 5:1 v/v hexane:EtOAc) to afford compound 1 in 22% yield (111 mg). 1H NMR (CDCl3, 500 MHz): 8.89 (dd, 1H, J = 2.3 and 0.6 Hz, ArH), 8.68 (ddd, 1H, J = 4.7,1.7 and 0.8 Hz, ArH), 8.448.36 (m, 2H, ArH), 7.93 (dd, 1H,J = 8.3 and 2.4 Hz, ArH), 7.82 (td, 1H, J = 7.8 and 1.8 Hz,ArH), 7.30 (ddd, 1H, J = 7.4, 4.8 and 1.1 Hz, ArH), 7.24(d, 1H, J = 3.5 Hz, ArH), 6.826.77 (m, 1H, ArH), 2.54 (s,3H, ArCH3) ppm. HR-MS (ESI+) m/z [M + H]+ calcd. for[C15H13N2S]+ 253.0799; found: 253.0803.

As the paragraph descriping shows that 15862-19-8 is playing an increasingly important role.

Reference：
Article; Kamila, Mritunjoy; Cosquer, Goulven; Breedlove, Brian K.; Yamashita, Masahiro; Bulletin of the Chemical Society of Japan; vol. 90; 5; (2017); p. 595 – 603;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

71071-46-0, Dimethyl [2,2′-bipyridine]-4,4′-dicarboxylate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

71071-46-0, General procedure: A solution of compound 5 (400mg, 0.822mmol), [(eta6-p-cymene) RuCl2]2 (252mg, 0.411mmol), and Me4NCl (450mg, 4.11mmol) in anhydrous acetone (21mL) was stirred under a dark atmosphere at room temperature for 6h. The reaction mixture was filtered and the filtrate was evaporated to afford crude compound as a bright orange solid. The above intermediate (200mg, 0.373mmol), dimethyl 2,2?-bipyridine-4,4?-dicarboxylate (203mg, 0.746mmol), and potassium hexafluorophosphate (103mg, 0.56mmol) were dissolved in dry 1,2-dichloroethane (20mL) and the mixture was stirred at 60°C for 12h. The mixture was then concentrated under reduced pressure and the resulting crude product was purified by column chromatography using ethyl acetate/ dichloromethane (1:1) to give compound 6 as a dark red solid (233mg, 70percent). 1H NMR (300MHz, CDCl3): delta 8.89 (s, 1H), 8.85 (s, 1H), 8.79 (s, 1H), 8.74 (s, 1H), 8.39 (d, J=5.7Hz, 1H), 8.00?7.91 (m, 3H), 7.82 (m, 3H), 7.67 (dd, J=3.6Hz, 1.5Hz, 1H), 7.52 (dt, J=8.7Hz, 1.2Hz, 1H), 7.46 (d, J=7.5Hz, 1H), 7.32?7.19 (m, 5H), 7.13 (d, J=5.7Hz, 1H), 6.72 (dt, J=6.5Hz, 1.5Hz, 1H), 3.95 (s, 3H), 3.94 (s, 3H), 3.93 (s, 3H), 3.91 (s, 3H), 1.27 (s, 3H); 13C NMR (125MHz, CDCl3): delta 192.8, 164.6, 164.4, 164.2, 162.6, 157.9, 157.8, 156.5, 156.3, 155.6, 151.9, 151.4, 150.5, 149.8, 142.5, 142.4, 138.4, 137.3, 136.6, 135.6, 135.3, 135.0, 134.9, 129.4, 128.5, 127.9, 127.6, 126.3, 162.2, 125.8, 123.0, 122.9, 122.4, 120.4, 118.8, 53.6, 53.5, 53.4, 53.3, 15.5; HRMS (FAB):calcd. for C44H36N5O8RuS [M+] 896.1328, found 896.1321.

As the paragraph descriping shows that 71071-46-0 is playing an increasingly important role.

Reference：
Article; Li, Chung-Yen; Su, Chaochin; Wang, Hsiou-Hsuan; Kumaresan, Prabakaran; Hsu, Chia-Hsuan; Lee, I-Ting; Chang, Wei-Chun; Tingare, Yogesh S.; Li, Ting-Yu; Lin, Chia-Feng; Li, Wen-Ren; Dyes and Pigments; vol. 100; 1; (2014); p. 57 – 65;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

27318-90-7, 1,10-Phenanthroline-5,6-dione is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution containing 1,10-phenanthroline-5,6-dione (1.6 mmol, 347 mg), substituted benzaldehyde (1.6 mmol), 20 ml of HAc and NH4Ac (33 mmol, 2.53 g), was heated at 110 °C under reflux for 4 h. Then, 20 ml of water was added and the pH value was adjusted to 7.0 at room temperature. The solution was filtered and dried in vacuum to obtain a yellow precipitate. The product was purified in a silica gel column by using ethanol as eluent. 1a: yield 78.4percent; mp. 217-219 °C, ESI-MS (in MeOH): m/z: 219.1, ([M + H]), 438.1,([M + 2H]2+). 2a: yield 79.5percent; mp. 226-228 °C, ESI-MS (in MeOH): m/z: 339.15, ([M + H]+), 678.1, ([M + 2H]2+). 3a: yield 64.4percent; mp. 262-265 °C, ESI-MS (in MeOH): m/z: 325.1, ([M + H]+), 650.3, ([M + 2H]2+). 4a: yield 75.7percent; mp. 234-236 °C, ESI-MS (in MeOH): m/z: 311.1, ([M + H]+). 5a: yield 67.1percent; mp. 232-235 °C, ESI-MS (in MeOH): m/z: 339.1, ([M + H]+). 6a: yield 67.7percent; mp. 280-283 °C, ESI-MS (in MeOH): m/z: 363.1, ([M + H]+), 726.1, ([M + 2H]2+). 7a: yield 63.4percent; mp. 269-273 °C, ESI-MS (in MeOH): m/z: 375.2, ([M + H]+), 750, ([M 2H]2+), 772.8, ([M + H + Na]2+).

27318-90-7, 27318-90-7 1,10-Phenanthroline-5,6-dione 72810, acatalyst-ligand compound, is more and more widely used in various fields.

Reference：
Article; Wu, Qiong; Fan, Cundong; Chen, Tianfeng; Liu, Chaoran; Mei, Wenjie; Chen, Sidong; Wang, Baoguo; Chen, Yunyun; Zheng, Wenjie; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 57 – 63;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

27318-90-7, 1,10-Phenanthroline-5,6-dione is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution containing 1,10-phenanthroline-5,6-dione (1.6 mmol, 347 mg), substituted benzaldehyde (1.6 mmol), 20 ml of HAc and NH4Ac (33 mmol, 2.53 g), was heated at 110 °C under reflux for 4 h. Then, 20 ml of water was added and the pH value was adjusted to 7.0 at room temperature. The solution was filtered and dried in vacuum to obtain a yellow precipitate. The product was purified in a silica gel column by using ethanol as eluent. 1a: yield 78.4percent; mp. 217-219 °C, ESI-MS (in MeOH): m/z: 219.1, ([M + H]), 438.1,([M + 2H]2+). 2a: yield 79.5percent; mp. 226-228 °C, ESI-MS (in MeOH): m/z: 339.15, ([M + H]+), 678.1, ([M + 2H]2+). 3a: yield 64.4percent; mp. 262-265 °C, ESI-MS (in MeOH): m/z: 325.1, ([M + H]+), 650.3, ([M + 2H]2+). 4a: yield 75.7percent; mp. 234-236 °C, ESI-MS (in MeOH): m/z: 311.1, ([M + H]+). 5a: yield 67.1percent; mp. 232-235 °C, ESI-MS (in MeOH): m/z: 339.1, ([M + H]+). 6a: yield 67.7percent; mp. 280-283 °C, ESI-MS (in MeOH): m/z: 363.1, ([M + H]+), 726.1, ([M + 2H]2+). 7a: yield 63.4percent; mp. 269-273 °C, ESI-MS (in MeOH): m/z: 375.2, ([M + H]+), 750, ([M 2H]2+), 772.8, ([M + H + Na]2+).

27318-90-7, 27318-90-7 1,10-Phenanthroline-5,6-dione 72810, acatalyst-ligand compound, is more and more widely used in various fields.

Reference：
Article; Wu, Qiong; Fan, Cundong; Chen, Tianfeng; Liu, Chaoran; Mei, Wenjie; Chen, Sidong; Wang, Baoguo; Chen, Yunyun; Zheng, Wenjie; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 57 – 63;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

22348-32-9, (R)-Diphenyl(pyrrolidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3A. Preparation of TMS-prolinolTo a mixture of prolinol (10.0 g, 39.5 mmol) and imidazole (4.57 g, 67.1 mmol) in THF (100 mL) was added chlorotrimethylsilane (5.57 g, 51.3 mmol) over 15 min while maintaining the batch temperature below 30 0C. The resulting slurry was aged at 50 0C for 3-5 h. The reaction mixture was cooled to ambient tempearture and quenched by addition of MTBE (50 mL) and 15% aq NaCl (100 mL). The organic layer was washed with 15% aq NaCl (50 mL). The solution was azeotropically dried at the constant volume by feeding THF.HPLC MethodColumn: Ascentis Express Cl 8 (100×4.6mm, 2.7um)Column temperature: 45 0CFlow rate: 1.5 ml/minDetection: UV at 210nmGradient:Time(min) 0.1% H^PO4 (0A) MeCN (0A)0 95 51 95 512 10 90Retention times (minutes): prolinol (4.8 min); TMS prolinol (7.3 min), 22348-32-9

The synthetic route of 22348-32-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SHARP &; DOHME CORP.; XU, Feng; DESMOND, Richard; HOERRNER, R. Scott; HUMPHREY, Guy, R.; ITOH, Tetsuji; JOURNET, Michel; YOSHIKAWA, Naoki; ZACUTO, Michael, J.; WO2010/144293; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22348-32-9,(R)-Diphenyl(pyrrolidin-2-yl)methanol,as a common compound, the synthetic route is as follows.

To (S)-diphenylprolinol (4.00 g, 15.8 mmol, 1.00 equiv) in CH2-Cl2 (40 mL) was added imidazole (3.22 g, 47.4 mmol, 3.00 equiv)at 0 C. TMSCl (5.00 mL, 39.5 mmol, 2.50 equiv) was added dropwiseand the reaction was stirred for 12 h at rt. MTBE (100 mL)was added to the reaction and the mixture was filtered. Theorganic phase was washed with H2O (50 mL) and saturated aqueousNaCl (2 50 mL), dried over MgSO4, filtered and concentratedunder reduced pressure to a colorless oil 11 (5.00 g, 15.3 mmol,97%). 1H NMR (400 MHz, CDCl3) d 7.54-7.46 (m, 2H), 7.42-7.36(m, 2H), 7.35-7.20 (m, 6H), 4.07 (t, J = 7.4 Hz, 1H), 2.98-2.75 (m,2H), 1.84-1.72 (m, 1H), 1.68-1.55 (m, 3H), 1.48-1.37 (m, 1H),0.06 (s, 9H) ppm. 13C NMR (101 MHz, CDCl3) d 146.83, 145.78,128.44, 127.61, 127.57, 127.53, 126.90, 126.73, 83.17, 65.42,47.16, 27.51, 25.06, 2.20 ppm. HR-MS (ESI): calculated for (C20H28-NOSi) [M+H]+: 326.1935, found: 326.1937., 22348-32-9

As the paragraph descriping shows that 22348-32-9 is playing an increasingly important role.

Reference：
Article; Murar, Claudia E.; Harmand, Thibault J.; Bode, Jeffrey W.; Bioorganic and Medicinal Chemistry; vol. 25; 18; (2017); p. 4996 – 5001;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

22348-32-9, (R)-Diphenyl(pyrrolidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3A. Preparation of TMS-prolinolTo a mixture of prolinol (10.0 g, 39.5 mmol) and imidazole (4.57 g, 67.1 mmol) in THF (100 mL) was added chlorotrimethylsilane (5.57 g, 51.3 mmol) over 15 min while maintaining the batch temperature below 30 0C. The resulting slurry was aged at 50 0C for 3-5 h. The reaction mixture was cooled to ambient tempearture and quenched by addition of MTBE (50 mL) and 15% aq NaCl (100 mL). The organic layer was washed with 15% aq NaCl (50 mL). The solution was azeotropically dried at the constant volume by feeding THF.HPLC MethodColumn: Ascentis Express Cl 8 (100×4.6mm, 2.7um)Column temperature: 45 0CFlow rate: 1.5 ml/minDetection: UV at 210nmGradient:Time(min) 0.1% H^PO4 (0A) MeCN (0A)0 95 51 95 512 10 90Retention times (minutes): prolinol (4.8 min); TMS prolinol (7.3 min), 22348-32-9

The synthetic route of 22348-32-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SHARP &; DOHME CORP.; XU, Feng; DESMOND, Richard; HOERRNER, R. Scott; HUMPHREY, Guy, R.; ITOH, Tetsuji; JOURNET, Michel; YOSHIKAWA, Naoki; ZACUTO, Michael, J.; WO2010/144293; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22348-32-9,(R)-Diphenyl(pyrrolidin-2-yl)methanol,as a common compound, the synthetic route is as follows.

To (S)-diphenylprolinol (4.00 g, 15.8 mmol, 1.00 equiv) in CH2-Cl2 (40 mL) was added imidazole (3.22 g, 47.4 mmol, 3.00 equiv)at 0 C. TMSCl (5.00 mL, 39.5 mmol, 2.50 equiv) was added dropwiseand the reaction was stirred for 12 h at rt. MTBE (100 mL)was added to the reaction and the mixture was filtered. Theorganic phase was washed with H2O (50 mL) and saturated aqueousNaCl (2 50 mL), dried over MgSO4, filtered and concentratedunder reduced pressure to a colorless oil 11 (5.00 g, 15.3 mmol,97%). 1H NMR (400 MHz, CDCl3) d 7.54-7.46 (m, 2H), 7.42-7.36(m, 2H), 7.35-7.20 (m, 6H), 4.07 (t, J = 7.4 Hz, 1H), 2.98-2.75 (m,2H), 1.84-1.72 (m, 1H), 1.68-1.55 (m, 3H), 1.48-1.37 (m, 1H),0.06 (s, 9H) ppm. 13C NMR (101 MHz, CDCl3) d 146.83, 145.78,128.44, 127.61, 127.57, 127.53, 126.90, 126.73, 83.17, 65.42,47.16, 27.51, 25.06, 2.20 ppm. HR-MS (ESI): calculated for (C20H28-NOSi) [M+H]+: 326.1935, found: 326.1937., 22348-32-9

As the paragraph descriping shows that 22348-32-9 is playing an increasingly important role.

Reference：
Article; Murar, Claudia E.; Harmand, Thibault J.; Bode, Jeffrey W.; Bioorganic and Medicinal Chemistry; vol. 25; 18; (2017); p. 4996 – 5001;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1148-79-4, 2,2′:6′,2”-Terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

UO2Cl2(terpy) (3): A mixture of 1.7 ml (0.2 mmol) UCl4/HCl 0.12 M, 93 mg (0.4 mmol) 2,2???:6???,2???-terpyridine, 2.3 ml (19 mmol) acetonitrile and 1.1 ml (12 mmol) pyridine was placed in a Parr vessel and then heated statically at 120 ?°C for 48 h. The resulting yellow product was then filtered off, washed with water and dried at room temperature (reaction yield 79percent). XRD powder pattern indicated that the compound was obtained as a pure phase (Supplementary Information S3)., 1148-79-4

As the paragraph descriping shows that 1148-79-4 is playing an increasingly important role.

Reference：
Article; Lhoste, Jerome; Henry, Natacha; Loiseau, Thierry; Guyot, Yannick; Abraham, Francis; Polyhedron; vol. 50; 1; (2013); p. 321 – 327;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI