Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71071-46-0,Dimethyl [2,2′-bipyridine]-4,4′-dicarboxylate,as a common compound, the synthetic route is as follows.

71071-46-0, A solution of compound 9 (200mg, 0.39mmol), dimethyl 2,2?-bipyridine-4,4?-dicarboxylate (212mg, 0.78mmol), and potassium hexafluorophosphate (108mg, 0.585mmol) in dry 1,2-dichloroethane (20mL) was stirred at 40°C for 24h. The reaction mixture was concentrated under reduced pressure and the crude product was purified by column chromatography using ethyl acetate/ dichloromethane (1:1) to give compound 10 as a dark red solid (198mg, 50percent). 1H NMR (300MHz, CDCl3): delta 8.88 (s, 1H), 8.83 (s, 1H), 8.75 (s, 2H), 8.27 (d, J=6Hz, 1H), 8.02 (dd, J=1.5Hz, 1.5Hz, 1H), 7.80 (d, J=5.4Hz, 1H), 7.84 (d, J=6.3Hz, 1H), 7.76(dd, J=1.5Hz, 1.5Hz, 1H), 7.69 (dd, J=1.5Hz, 1.5Hz, 1H), 7.59?7.64 (m, 5H), 7.30(d, J=5.4Hz, 1H), 7.01?7.16 (m, 1H), 6.89 (q, J=5.4Hz, 1H), 6.52 (q, J=7.8Hz, 1H), 4.00 (s, 3H), 3.99 (s, 3H), 3.98 (s, 3H), 3.96 (s, 3H); 13C NMR (125MHz, CDCl3): delta 181.4, 164.3, 164.3, 164.1, 163.9, 162.1, 159.5 (d, JCF=252.1Hz), 157.9, 157.3, 156.6, 156.4, 155.4, 151.6, 150.7, 150.4, 145.6, 138.4, 137.2, 136.3, 135.8, 135.7, 135.4, 135.2, 128.1, 126.2, 126.1, 125.8, 125.7, 125.1, 122.8, 122.7, 122.1, 121.9, 121.6, 120.0, 119.0, 109.5 (d, JCF=22.7Hz), 53.4, 53.3, 53.2; HRMS (FAB): calcd. for C41H31FN5O8SRu [M+] 874.0921, found 874.0923.

71071-46-0 Dimethyl [2,2′-bipyridine]-4,4′-dicarboxylate 326419, acatalyst-ligand compound, is more and more widely used in various fields.

Reference：
Article; Li, Chung-Yen; Su, Chaochin; Wang, Hsiou-Hsuan; Kumaresan, Prabakaran; Hsu, Chia-Hsuan; Lee, I-Ting; Chang, Wei-Chun; Tingare, Yogesh S.; Li, Ting-Yu; Lin, Chia-Feng; Li, Wen-Ren; Dyes and Pigments; vol. 100; 1; (2014); p. 57 – 65;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

22348-32-9, (R)-Diphenyl(pyrrolidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3A. Preparation of TMS-prolinolTo a mixture of prolinol (10.0 g, 39.5 mmol) and imidazole (4.57 g, 67.1 mmol) in THF (100 mL) was added chlorotrimethylsilane (5.57 g, 51.3 mmol) over 15 min while maintaining the batch temperature below 30 0C. The resulting slurry was aged at 50 0C for 3-5 h. The reaction mixture was cooled to ambient tempearture and quenched by addition of MTBE (50 mL) and 15% aq NaCl (100 mL). The organic layer was washed with 15% aq NaCl (50 mL). The solution was azeotropically dried at the constant volume by feeding THF.HPLC MethodColumn: Ascentis Express Cl 8 (100×4.6mm, 2.7um)Column temperature: 45 0CFlow rate: 1.5 ml/minDetection: UV at 210nmGradient:Time(min) 0.1% H^PO4 (0A) MeCN (0A)0 95 51 95 512 10 90Retention times (minutes): prolinol (4.8 min); TMS prolinol (7.3 min)

22348-32-9, The synthetic route of 22348-32-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SHARP &; DOHME CORP.; XU, Feng; DESMOND, Richard; HOERRNER, R. Scott; HUMPHREY, Guy, R.; ITOH, Tetsuji; JOURNET, Michel; YOSHIKAWA, Naoki; ZACUTO, Michael, J.; WO2010/144293; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1148-79-4, 2,2′:6′,2”-Terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

UO2Cl2(terpy) (3): A mixture of 1.7 ml (0.2 mmol) UCl4/HCl 0.12 M, 93 mg (0.4 mmol) 2,2???:6???,2???-terpyridine, 2.3 ml (19 mmol) acetonitrile and 1.1 ml (12 mmol) pyridine was placed in a Parr vessel and then heated statically at 120 ?°C for 48 h. The resulting yellow product was then filtered off, washed with water and dried at room temperature (reaction yield 79percent). XRD powder pattern indicated that the compound was obtained as a pure phase (Supplementary Information S3)., 1148-79-4

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Reference：
Article; Lhoste, Jerome; Henry, Natacha; Loiseau, Thierry; Guyot, Yannick; Abraham, Francis; Polyhedron; vol. 50; 1; (2013); p. 321 – 327;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15862-19-8,5-Bromo-2,2′-bipyridine,as a common compound, the synthetic route is as follows.,15862-19-8

5-bromo-2,2-bipyridine (0.480 g, 2 mmol), 2-methylthiophene (0.401 g, 4 mmol) and KOAc (0.401 g, 4 mmol) in dryDMA (5 mL) were stirred under N2 at 150 C for 20 h in thepresence of Pd(OAc)2 (0.009 g, 2 mol%). After cooling the solution to room temperature, CH2Cl2 (15 mL) and an aqueoussaturated NH4Cl solution (10 mL) were added. The reactionsolution was extracted three times with 15 mL of CH2Cl2, andthe combined organic layers were washed three times with 10mL of water. The solvent was evaporated under reduced pressure, and the crude product was purified by using columnchromatography (silica; 5:1 v/v hexane:EtOAc) to afford compound 1 in 22% yield (111 mg). 1H NMR (CDCl3, 500 MHz): 8.89 (dd, 1H, J = 2.3 and 0.6 Hz, ArH), 8.68 (ddd, 1H, J = 4.7,1.7 and 0.8 Hz, ArH), 8.448.36 (m, 2H, ArH), 7.93 (dd, 1H,J = 8.3 and 2.4 Hz, ArH), 7.82 (td, 1H, J = 7.8 and 1.8 Hz,ArH), 7.30 (ddd, 1H, J = 7.4, 4.8 and 1.1 Hz, ArH), 7.24(d, 1H, J = 3.5 Hz, ArH), 6.826.77 (m, 1H, ArH), 2.54 (s,3H, ArCH3) ppm. HR-MS (ESI+) m/z [M + H]+ calcd. for[C15H13N2S]+ 253.0799; found: 253.0803.

As the paragraph descriping shows that 15862-19-8 is playing an increasingly important role.

Reference：
Article; Kamila, Mritunjoy; Cosquer, Goulven; Breedlove, Brian K.; Yamashita, Masahiro; Bulletin of the Chemical Society of Japan; vol. 90; 5; (2017); p. 595 – 603;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of 1941-30-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1941-30-6, Name is Tetrapropylammonium bromide, molecular formula is C12H28BrN. In a Article，once mentioned of 1941-30-6

The conversion of methyl octanoate on an H-ZSM5 zeolite catalyst has been investigated as a model reaction for the production of hydrocarbon fuels and chemicals from biodiesel. The reactivity of methyl octanoate on H-ZSM5 is higher than that observed with a linear alkane of the same chain length as the ester, n-octane. The enhanced activity may be due to the strong adsorption of the ester group on the zeolite sites. The deoxygenation of methyl octanoate yielded a variety of hydrocarbons (C1-C7), with significant amounts of aromatics. Octanoic acid and heavy products, particularly 8-pentadecanone, were formed as primary products from methyl octanoate via acid-catalyzed hydrolysis and condensation, respectively. Both octanoic acid and the condensation products undergo further reaction, producing aromatics. The comparison conducted with n-octane as a feed indicates that aromatics can be formed through a series of reactions, namely cracking, oligomerization, and cyclization. A small amount of ethylbenzene and o-xylene at low conversion of methyl octanoate indicates that direct dehydrocyclization may also take place, but this path was not evident when the feed was n-octane.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, SDS of cas: 29841-69-8, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 29841-69-8, Name is (1S,2S)-(-)-1,2-Diphenylethylenediamine, molecular formula is C14H16N2. In a Conference Paper, authors is Gelalcha, Feyissa Gadissa，once mentioned of 29841-69-8

A novel and general biomimetic non-heme Fe-catalyzed asymmetric epoxidation of aromatic alkenes by using hydrogen peroxide is reported herein. The catalyst consists of ferric chloride hexahydrate (FeCl3·OH 2O), pyridine-2,6-dicarboxylic acid (H2-(pydic)), and readily accessible chiral N-arenesulfonyl-N?-benzyl-substituted ethylenediamine ligands. The asymmetric epoxidation of styrenes with this system gave high conversions but poor enantiomeric excesses (ee), whereas larger alkenes gave high conversions and ee values. For the epoxidation of trans-stilbene (1a), the ligands (S,S)-N-(4-toluenesulfonyl)-1,2- diphenylethylenediamine ((S,S)-4a) and its N?-benzylated derivative ((S,S)-5a) gave opposite enantiomers of trans-stilbene oxide, that is, (S,S)-2a and (R,R)-2a, respectively. The enantioselectivity of alkene epoxidation is controlled by steric and electronic factors, although steric effects are more dominant. Preliminary mechanistic studies suggest the in situ formation of several chiral Fe-complexes, such as [FeCl(L*)2-(pydic)] ·HCl (L* = (S,S)-4a or (S,S)-5a in the catalyst mixture), which were identified by ESIMS. A UV/Vis study of the catalyst mixture, which consisted of FeCl3·6H2O, H2(pydic), and (S,S)-4a, suggested the formation of a new species with an absorbance peak at lambda = 465 nm upon treatment with hydrogen peroxide. With the aid of two independent spin traps, we could confirm by EPR spectroscopy that the reaction proceeds via radical intermediates. Kinetic studies with deuterated styrenes showed inverse secondary kinetic isotope effects, with values of k H/kD = 0.93 for the beta carbon and kH/k D=0.97 for the a carbon, which suggested an unsymmetrical transition state with stepwise O transfer. Competitive epoxidation of para-substituted styrenes revealed a linear dual-parameter Hammett plot with a slope of 1.00. Under standard conditions, epoxidation of la in the presence of ten equivalents of H218O resulted in an absence of the isotopic label in (S,S)-2a. A positive non-linear effect was observed during the epoxidation of la in the presence of (S,S)-5a and (R,R)-5a.

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 112068-01-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.112068-01-6, Name is (S)-Diphenyl(pyrrolidin-2-yl)methanol, molecular formula is C17H19NO. In a Article，once mentioned of 112068-01-6

A series of bis-hydroxyamides were synthesized from diphenylamine-2,2?-dicarboxylic acid and chiral aminoalcohols. Their catalytic activity in asymmetric borane reduction was investigated. After the fine optimization of solvents, temperature, amount of borane complex, and the length of catalyst generating period, good to excellent yields (55-99%) and enantioselectivities (79-97% ee) can be achieved in the reduction of aromatic and alkyl prochiral ketones. A transition state structure was proposed on the basis of absolute configuration and controlled experiment.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 112068-01-6

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1660-93-1, name is 3,4,7,8-Tetramethyl-1,10-phenanthroline, introducing its new discovery. Recommanded Product: 1660-93-1

The efficiency and performance of lead oxide nanoparticles loaded activated carbon were well investigated and elucidated for the removal of methyl orange dye. The influence of variables like; pH, contact time, MO concentration and mass of adsorbent was investigated and optimized by artificial neural network-partial swarm optimization (ANN-PSO). At optimal conditions predicted by ANN-PSO, the coefficient of determination (R2) and mean square error (MSE) correspond to test data were 0.97 and 0.00093, respectively. The maximum removal percentage (~ 98%) was observed at conditions set at: 0.02 g of PbO-NP-AC, 15 mg L- 1 of MO at pH 2.0 following mixing and stirring for 20 min. The experimental data were efficiently explained by the Langmuir isotherm model at all conditions with maximum adsorption capacity of 333.33 mg g- 1. Kinetic studies at various adsorbent mass and initial MO concentrations revealed that maximum MO removal was achieved within 15 min. The experimental data follow the pseudo-second-order rate equation.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1660-93-1 is helpful to your research. Recommanded Product: 1660-93-1

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Safety of (1S,2S)-(-)-1,2-Diphenylethylenediamine, Which mentioned a new discovery about 29841-69-8

The first uncatalyzed hydrophosphinations of propargylic amines and alcohols with phosphine- borane complexes are described. The reactions proceed at ambient temperature or below without the use of protecting groups or the need to handle pyrophoric secondary phosphines, furnishing air-stable phosphineborane-amines and alcohols in good yields. Utilization of chiral propargylic substrates and unsymmetrical secondary phosphineboranes leads to diastereomeric P-chiral products that can be separated by fractional crystallization or chromatography. Initial applications of these new P-X species to asymmetric catalysis are detailed.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Safety of (1S,2S)-(-)-1,2-Diphenylethylenediamine, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 29841-69-8

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1941-30-6, name is Tetrapropylammonium bromide, introducing its new discovery. SDS of cas: 1941-30-6

This paper studied nitrous oxide decomposition over a series of transition metal exchanged ZSM-5 zeolites prepared by solid-state ion-exchange method. Crystallographic structure of the catalysts has been investigated with the aid of XRD analysis. The texture of the prepared catalysts was investigated using nitrogen sorption. FTIR measurements applying pyridine as a probe molecule have been carried out in order to investigate the nature of the acid sites of the different catalysts. In situ electrical conductivity measurements were carried out in order to relate the activity of this series of catalysts to their electrical conductivity variation in the presence of N2O. The obtained results revealed that the N2O decomposition activity is related to the relative conductivity decrease upon the admission of N2O over metal exchanged ZSM-5 zeolites. Further studies have been performed over Co-, Cu- and Fe-ZSM-5 catalysts since they showed the highest activity patterns among all the tested catalysts. Such studies included the effect of changing Si/Al ratio, the exchange level, the calcination temperature and the milling time.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1941-30-6 is helpful to your research. SDS of cas: 1941-30-6

Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI