Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.

To a solution of (S,S)-diphenylethylenediamine (250 mg, 1.2 MMOL) and triethylamine (0.5 ml) in THF is added dropwise a solution of dansyl chloride (318 mg, 1.2 MMOL) in THF (2 ml) at 0 C. After stirring 16 h at RT the solvent is removed in vacuum and the residue is resolved in METHYLENCHLORIDE (20 ml). The organic solution is washed with NaHCO3 SOLUTION (5 ml), dried over Na2SO4 AND after filtration the solvent is removed. Flash chromatographie afford (S,S)-5-dimethylamino-naphthalene-1-sulfonic acid (2-amino-1,2- diphenyl-ethyl)-amide as yellow oil which crystallizes by drying in vacuum. M: 445. 59. 1H-NMR (400 MHz, CDCI3): 8.36 (t, J=7.5 Hz, 2H), 8.17 (dd, J=7.2, 1.2 Hz, 1H), 7.47 (dd, J=8.8 Hz, 1H), 7.34 (dd, J=8.5 Hz, 1H), 7.24-7.16 (m, 4 H), 7.11 (d, J=7.5 Hz, 1H), 6.99-6.74 (m, 6 H), 4.61 (d, J=8.5 Hz, 1 H), 4.20 (d, J=8.5Hz, 1 H), 2.80 (s, 6 H)., 29841-69-8

29841-69-8 (1S,2S)-(-)-1,2-Diphenylethylenediamine 6931238, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Novartis AG; Novartis Pharma GmbH; WO2004/31155; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99970-84-0,[2,2′-Bipyridine]-4,4′-dicarbaldehyde,as a common compound, the synthetic route is as follows.,99970-84-0

General procedure: 4-methyl-2,2?-bipyridine-4-formaldehyde (200mg, 1.01mmol) anddichloromethane (10 mL) were added into a 50 mL two-neck roundbottle flask under nitrogen. Then ethyl mercaptan (250 muL) and borontrifluoride ether solution (98%, 700 muL) were added into the flask.After the mixture was stirring at room temperature for one night, thesolvent were removed with rotary evaporator in vacuum. Then the saturatedsodium bicarbonate solution (50 mL) were added, the aqueoussolution was extracted with ethyl acetate five times. All organic layerswere collected and dried with anhydrous sodium sulfate, filtered andevaporated to dryness. The residue was purified by column chromatographyon silica gelwith dichloromethane as eluent to give the first bandas the product. The product is a colorless transparent oil (200mg) witha yield of 64.5%.

The synthetic route of 99970-84-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xu, Jiru; Liu, Yonghua; Li, Mei-Jin; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 219; (2019); p. 141 – 146;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,128143-89-5

was added to a stirred suspensionof KOH (1.05 g, 18.7 mmol) in anhydrous DMSO(20 mL) at 60 C. After 60 min, 40-chloro-2,20:60,200-terpyridine (1.00 g, 3.7 mmol) was added to the mixture,which was maintained with stirring for 4 h at 70 C. Distilledwater (600 mL) was then added to the reaction mixture,and the product was extracted with CH2Cl2(3 ¡Á 200 mL). Residual water in the CH2Cl2 was removedusing Na2SO4, and the CH2Cl2 was removed using a rotaryevaporator. The desired product was recrystallized fromethyl acetate to give 0.72 g (72%) of 4. 1H NMR(300 MHz, CDCl3-d) 8.7 (d, 2H, J = 4.7 Hz), 8.6 (d, 2H,J = 7.4 Hz), 8.0 (m, 4H), 7.5 (m, 2H), 4.0 (m, 2H), 3.2(dd, 1H, J = 6.3 Hz and J = 12.5 Hz) 1.7 (s, 2H), 1.1 (d,3H, J = 6.4 Hz). 13C NMR (125 MHz, CDCl3-d) 160.2,156.5, 154.2, 148.9, 123.7, 120.8, 105.2, 70.1, 48.1, 21.4.ESI-MS (m/z) calcd. For C18H18N4O: 306.2; 307.307[M + H]+. Elemental analysis: calculated for C18H18N4O:C 70.6, H 5.9, N 18.3. Found: C 70.2, H 5.5, N 18.1.

128143-89-5 4′-Chloro-2,2′:6′,2”-terpyridine 667748, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Kim, Ka Young; Kim, Jaehyeong; Park, Hyesong; Choi, Yeonweon; Kwon, Ki-Young; Jung, Jong Hwa; Bulletin of the Korean Chemical Society; vol. 39; 8; (2018); p. 988 – 994;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Powdered KOH (280mg, 5mmol) was added to 10mL dry dimethyl sulfoxide (DMSO) and 8-Amino-1-octanol (152.5mg, 1.05mmol) was then added and stirred at 60C for 1h. Then, 4?-Chloro-2,2′:6?,2?-terpyridine (268mg, 1.0mmol) was added, and the resulting mixture was stirred at 60C for 48h. After cooled to room temperature, the reaction mixture was poured into deionized water (200mL) to yield precipitation, which was collected by filtration. The yellow solid was washed with deionized water, and then dried under vacuum overnight to afford 290mg of the desired product in 77% yield [30]. 1H NMR (400MHz, CDCl3) delta 8.74-8.66 (m, 2H), 8.62 (d, J=8.0Hz, 2H), 8.02 (d, J=9.1Hz, 2H), 7.85 (td, J=7.8, 1.8Hz, 2H), 7.33 (ddd, J=7.5, 4.8, 1.1Hz, 2H), 4.22 (t, J=6.4Hz, 2H), 2.69 (t, J=7.0Hz, 2H), 1.90-1.81 (m, 2H), 1.56-1.28 (m, 10H). HRMS [M+ H]+ calcd for C23H29N4O+ 377.2341; found: 377.2340. Anal Cald for C23H28N4O: C, 73.37; H, 7.50; N, 14.88; Found: C, 73.32; H, 7.85; N, 14.75., 128143-89-5

The synthetic route of 128143-89-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hou, Zhaohui; Li, Peng; Wang, Huan-Yu; Li, Zhiqiang; Li, Huanrong; Dyes and Pigments; vol. 147; (2017); p. 429 – 435;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17217-57-1,4,4′-Dimethoxy-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: [Cu(MeCN)4]PF6 (75 mg, 0.20mmol) was added to dppp (82 mg, 0.20mmol) in 5mL of dichloromethane. Then, bpy (32 mg, 0.20mmol) was added and the solution immediately changed to yellow. The reaction mixture was stirred for 30 min at room temperature. Diethyl ether was added to the solution to precipitate the product as a yellow solid, which was filtered and washed with diethyl ether: yield, 126 mg (0.162mmol, 81percent)., 17217-57-1

As the paragraph descriping shows that 17217-57-1 is playing an increasingly important role.

Reference£º
Article; Nishikawa, Michihiro; Tsubomura, Taro; Bulletin of the Chemical Society of Japan; vol. 87; 8; (2014); p. 912 – 914;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

153-94-6, H-D-Trp-OH is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Thionyl chloride (9.87 mmol, 0.72 mL) was added dropwise to a solution of D-tryptophan (1.000 g, 4.89 mmol) in methanol (33 mL). The reaction was heated to reflux with vigorous stirring for 24 h. After cooling, the reaction mixture was concentrated under reduced pressure and residual methanol traces removed by azeotropic distillation with dichloromethane (10 mL) under reduced pressure to give the title compound as a white solid (1.070 g, 86%). [0401] 1H NMR (500 MHz, D2O) delta=7.52 (1H, d, J=7.9, 9-H), 7.46 (1H, d, J=8.1, 12-H), 7.26-7.10 (3H, m, 4, 5, 9-H), 4.37 (1H, t, J=6.0, 2-H), 3.73 (3H, s, beta-H), 3.44-3.31 (2H, m, 4-H). [0402] 13C NMR (126 MHz, D2O) delta=170.4 (2-C), 136.3 (7-C), 126.4 (8-C), 125.4 (6-C), 122.3 (11-CH), 119.6 (10-CH), 118.1 (9-CH), 112.1 (12-CH), 106.0 (5-C), 53.6 (13-CH3), 53.3 (2-CH), 25.7 (4-CH2). [0403] IR (diamond, vMAX, cm-1) 3261 (NH st), 2870 (N+-H st), 2023 (Ar comb), 1748 (C?O st), 1229, 1211 (CO-O st as), 1181 (C-O st as). [0404] Acc. Mass (FAB): C12H15N2O2 Found: 219.1120 m/z Calculated: 219.1128 m/z., 153-94-6

The synthetic route of 153-94-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The University of Sussex; Viseux, Eddy Michel Elie; Gallop, Christopher; Bobin, Mariusz; US2014/39200; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4479-74-7,2,2-Bipyridine-6,6-dicarboxylic Acid,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 2,2?-bipyridine-6,6?-dicarboxylic acid (244 mg,1.0 mmol), Ru(DMSO)4Cl2 (484 mg, 1.0 mmol), and Et3N (0.8ml) in methanol (10 ml) was degassed with N2 and refluxed for 4 h. The solution changed from bright yellow to dark before the appearance of a brown precipitate. After cooling to room temperature, the precipitate was filtered and washed with methanol (10 ml ¡Á 3) and ether (10 ml ¡Á 3) to get a reddish-brown powder. The powder was mixed with an excess of 4,4?-bipyridine in methanol (20 ml) and heated to reflux for 2 h. The solvent was removed and the resulted residue was re-dissolved in dichloromethane, washed with water to remove triethylamine hydrochloride, and dried over MgSO4 under N2. After purification by column chromatography on silica gel with dichloromethane-methanol (20:1 to 1:1, V:V) as eluent, complex1 was obtained as a dark red solid. Yield: 229 mg (35%)., 4479-74-7

The synthetic route of 4479-74-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jiang, Yi; Li, Fei; Huang, Fang; Zhang, Biaobiao; Sun, Licheng; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 34; 8; (2013); p. 1489 – 1495;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

3779-42-8, 3-Bromo-N,N,N-trimethylpropan-1-aminium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

COMPOUND 36; 5.10,15-tris-[4-(3-Trimethyl-ammoniopropyloxy)-phenyl]-20-(4- tetradecyloxy-phenyl )-porplryrin trichloride; The n-tetradecyloxy-analogue of Compound 2, prepared similarly as described above for Compound 2 but using 1-bromotetradecane in place of 1-bromoundecane, (50 mg, 0.057 mmol) and (l-bromopropyl)- trimethylammonium bromide (210 mg, 0.8 mmol) are dissolved and K2CO3 (230 mg, 1.7 mmol) is suspended in DMF (20 mL). The vigorously stirred mixture is stirred at this temperature for 18 h. After removal of DMF under reduced pressure the residue obtained is dissolved in methanol (5 mL) and filtered through a pad of silica gel (depth 2 cm) supported on a steel frit (diameter 3.5 cm). After washing the pad with methanol (ca. 500 mL) it is eluted with acetic acid:methanol .-water (3 :2:1, by vol.). After evaporation of the solvent from appropriately combined fractions, the residue obtained is purified by chromatography on a column (2.5 x 40 cm) of Sephadex LH-20 eluting with n-butanol:water:acetic acid (4:5:1, by vol., upper phase) for separation from the excess of ammonium salt and other contaminating materials. After elution and removal of the solvent from appropriate fractions, the residue obtained is dissolved in methanol (5 mL) and passed through a short column (3.5 x 20 cm) of anion exchange resin (Amberlite IRA 400, chloride form). Solvent is removed under reduced pressure and the residue obtained is dried under high vacuum to afford the product as a violet solid.1H-NMR: deltaH (300MHz, CD3OD): 0.75 (t, 3J 7.5 Hz, 3 H), 0.95-1.25 (m, 22 H), 1.50-1.65 (bs, 2 H), 2.20-2.40 (bs, 6 H)5 3.05-3.15 (bs, 27 H), 3.45-3.60 (bs, 6 H), 3.60-3.80 (bs, 2 H), 4.05-4.25 (bs, 6 H), 6.80-7.25, 7.65-8.05, (2 x m, 16 H)5 8.45-8.95 (bs, 8 H)., 3779-42-8

3779-42-8 3-Bromo-N,N,N-trimethylpropan-1-aminium bromide 151145, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; DESTINY PHARMA LIMITED; WO2006/765; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2 or 3 (0.50 mmol), the corresponding acids RCOOH (0.60 mmol),DCC (0.60 mmol), DMAP (0.1 mmol) in dry dichloromethane (15 mL) was stirred atroom temperature. When the reaction was completed, and checked by TLC, the mixturewas filtered to remove urea from the reaction, and the filtrate was diluted bydichloromethane (45 mL). Subsequently, the diluted organic phase was washed bysaturated aqueous NaHCO3 (30 mL), and brine (30 mL), dried over anhydrousNa2SO4, concentrated in vacuo, and purified by CC to give the pure 9R/S-acyloxyderivatives of cinchonidine and cinchonine 5a-j,l-o and 6a,c,e-o [17-19]. The dataof target compounds are shown as follows.

485-71-2, 485-71-2 Cinchonidine 101744, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Che, Zhi-Ping; Chen, Gen-Qiang; Jiang, Jia; Lin, Xiao-Min; Liu, Sheng-Ming; Sun, Di; Tian, Yue-E; Yang, Jin-Ming; Zhang, Song; Journal of Asian Natural Products Research; (2020);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

137848-29-4, (S)-2′-Amino-[1,1′-binaphthalen]-2-ol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 100 ml single-necked flask, 0.74 g of picolinic acid, 1.43 g of (S)-NOBIN and 25 ml of THF were added, and after stirring at room temperature for 10 minutes to fully dissolve, 1.52 g of dehydrating agent DMTMM was added.Continue to stir at room temperature and track by TLC until the raw NOBIN disappears.Add 20 ml of water, stir for 10 min to separate the aqueous layer and extract three times with ether, 20 ml each time.Combine the organic layers and use 5 ml of saturated sodium bicarbonate solution in order.After washing with saturated saline and a 5% dilute hydrochloric acid solution, it was dried over anhydrous sodium sulfate.The crude product after filtration and concentration under reduced pressure was chromatographed on a 25 g silica gel column to obtain 1.75 g of a white amide solid with a yield of 90%.

137848-29-4, 137848-29-4 (S)-2′-Amino-[1,1′-binaphthalen]-2-ol 3617797, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Dalian Institute of Chemical Physics; Hu Xiangping; Hu Xinhu; (10 pag.)CN110551036; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI