Tag: M.W:200-300

109073-77-0, [2,2′-Bipyridine]-4,4′-diyldimethanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Cobalt(II) tetrafluoroborate hexahydrate (156mg, 0.46mmol) was added to 4,4?-Bis(hydroxymethyl)-2,2?-bipyridine 8 (408mg, 1.89mmol) dissolved in absolute ethanol (37mL). The solution was refluxed under stirring for 24h, concentrated and dried under vacuum. The solid was dissolved in a minimum of methanol and dichloromethane was added slowly. The formed precipitate was filtrated and washed with dichloromethane, leading to a yellow solid. Yield: 95%,, 109073-77-0

The synthetic route of 109073-77-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; He; Fontmorin; Hapiot; Soutrel; Floner; Fourcade; Amrane; Geneste; Electrochimica Acta; vol. 207; (2016); p. 313 – 320;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1671-87-0, 3,6-Di(pyridin-2-yl)-1,2,4,5-tetrazine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1671-87-0, A 10-3 M solution of compound 4 in 1:1 ethanol:H2O and a 10-2 M solution of compound 12 in ethanol were prepared separately. 50 muL of the 10-3 M solution of compound 4 and 50 muL of the 10-2 M solution of compound 12 were added to a glass vial containing 1 mL of 10% untreated rabbit reticulocyte lysate in H2O. The solution was stirred at room temperature for 1 hr. The solution was extracted with ether and CH2Cl2, dried over Na2SO4, filtered through celite, and concentrated in vacuo. The resulting residue was diluted with 100 muL of methanol and analyzed by ESI-MS and compound 13 was detected. The yield was 76% versus an internal standard.

The synthetic route of 1671-87-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; University of Delaware; US2009/23916; (2009); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4568-71-2,3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Example 22 3-Ethoxycarbonyl-2-(4-fluoro-3-phenoxy-phenyl)-5-methyl-1-phenylhexane-1,4-dione STR36 142.4 g (0.4 mol) of Example 21 are heated at reflux overnight with 42.4 g (0.4 mol) of benzaldehyde, 10.8 g (0.04 mol) of 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride and 33 ml of triethylamine in 270 ml of ethanol. The solvent is removed in vacuo, and the residue is dissolved in chloroform, washed twice with 1N sulphuric acid, water and saturated bicarbonate solution and dried over sodium sulphate. After concentrating to dryness, 185.2 g of yellowish oil remain. The crude product is sufficiently pure for further processing. Rf =0.17 (petroleum ether/ethyl acetate 10:1).

4568-71-2, The synthetic route of 4568-71-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bayer Aktiengesellschaft; US4968681; (1990); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

137848-29-4, (S)-2′-Amino-[1,1′-binaphthalen]-2-ol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3,5-Di-tert-butylsalicylaldehyde (2.35 g, 10.0 mmol) was mixed with (S)-2-amino-2′-hydroxy-1,1′-binaphthyl (2.85 g, 10.0 mmol) in dry toluene (30 mL). A few 4 A molecular sieves were added, and the solution was warmed up to 70 C and kept for two days at this temperature. The solution was filtered and the solvent was removed under reduced pressure. The resulting yellow oily residue (crude 1) was dissolved in a mixed solvent (40 mL) of methanol and toluene (v/v = 1:3), NaBH4 (2.00 g, 52.6 mmol) was added in small portions at 0 C, then the solution was warmed up to 50 C and kept for 2 h at this temperature. The solvent was removed and the residue was treated with H2O (20 mL) and extracted with ethyl acetate (20 mL ¡Á 3) and washed with brine (20 mL). The combined organic layers were dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure to give a yellow solid, which was further purified by flash column chromatography (hexane/ethyl acetate = 10:1) to give 4H3 as a yellow solid. Yield: 4.75 g (95%).

137848-29-4, The synthetic route of 137848-29-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhao, Ning; Chen, Liang; Ren, Wenshan; Song, Haibin; Zi, Guofu; Journal of Organometallic Chemistry; vol. 712; (2012); p. 29 – 36;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

17217-57-1, 4,4′-Dimethoxy-2,2′-bipyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: All the solvents used in this work were of reagent quality and usedwithout further purification. Lapachol was obtained according to theprocedure described in [24]. The precursors cis-[RuCl2(PPh3)2(X-bipy)](X = H, methyl (Me) and methoxy (MeO)) and cis-[RuCl2(PPh3)2(phen)] were prepared according to literature [26,27]. Typically[100.0 mg; 0.1 mmol] of the [RuCl2(PPh3)3] was dissolved in degassed20 mL of dichloromethane (Merck) and N-heterocyclic (X-bipy or phen) [22.0 mg; 0.11 mmol] ligand was added. The reaction mixturewas stirred for 30 min at room temperature and the volume of theresulting blue solution was reduced, under vacuum, to ca. 2 mL anddiethyl ether (Merck) was then added to precipitate a red solid, whichwas filtered off, washed several times with diethyl ether, and driedunder vacuum. Yield: ~78 mg (80?90percent)., 17217-57-1

17217-57-1 4,4′-Dimethoxy-2,2′-bipyridine 2733927, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Barbosa, Marilia I.F.; Correa, Rodrigo S.; De Oliveira, Katia Mara; Rodrigues, Claudia; Ellena, Javier; Nascimento, Otaciro R.; Rocha, Vinicius P.C.; Nonato, Fabiana R.; Macedo, Tais S.; Barbosa-Filho, Jose Maria; Soares, Milena B.P.; Batista, Alzir A.; Journal of Inorganic Biochemistry; vol. 136; (2014); p. 33 – 39;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485-71-2,Cinchonidine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of (-)-cinchonidine (1.0 mmol) and benzyl bromide 3 (1.0 mmol) having sulfonamidegroup was stirred in DMF (4 mL) at 25 C for 20 h. After the reaction was completed, the reaction mixture was added dropwise to ether (50mL) with stirring. The solid precipitated was filtered,washed with ether (20 mL) and hexane (20 mL) to afford cinchonidinium salt 5

485-71-2 Cinchonidine 101744, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Itsuno, Shinichi; Yamamoto, Shunya; Takata, Shohei; Tetrahedron Letters; vol. 55; 44; (2014); p. 6117 – 6120;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2304-30-5,Tetrabutylphosphonium chloride,as a common compound, the synthetic route is as follows.

2. Preparation of 2-Chlorosulfonyl-7-fluoro-5-methoxy-[1,2,4]triazolo[1,5-c]pyrimidine A mixture of 5.0 g (13 mmol) of 2,2′-dithiobis-(7-fluoro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine), 75 mL of dichloromethane, 25 mL of water, and 0.3 g (1.0 mmol) tetrabutylphosphonium chloride was cooled to 3 C. and 6.0 g (8.5 mmol) of chlorine gas was added with stirring and cooling. The mixture was allowed to react at 0 to 3 C. with stirring for 2 hours by which time the initial slurry had become clear leaving two liquid phases. The phases were separated and the organic phase was concentrated by evaporation under reduced pressure to obtain 7.5 g of the title compound in impure form as a white solid. 1 H NMR Spectrum (300 MHz) in CDCl3: 6.96(s, 1 H), 5.29(s, 1 H), 4.40(s, 3 H)., 2304-30-5

The synthetic route of 2304-30-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dow AgroSciences LLC; US6162915; (2000); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2,485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The alkaloid (12.3 mmol, 1 eq.) and the appropriate substituted benzylic halide derivative(12.3 mmol, 1 eq.) were dissolved in THF (40 mL) with addition of a trace of NaI. The mixture washeated to reflux overnight and then cooled and stirred at ambient temperature for 1 h. In most cases theproduct precipitated as an off-white solid, but where this was not the case and the mixture containedonly a small amount of solid or no solid at all, then diethyl ether (20 mL) was added dropwise.The solid was removed via filtration and washed with THF (50 mL) or ether:THF, (1:1, v/v, 50 mL)and was dried under reduced pressure at 40 C. Where the solid formed was not a fine powder it was then taken up in DCM and this solution was then added dropwise to rapidly stirring ether (100 mL).This usually gives a finely divided solid that could be filtered and dried. (Note: The cinchonine derivedPTCs are usually very insoluble. The quinidine derived PTCs are often completely soluble at the endof the reaction.) The di(t-butyl)benzyl PTC was prepared according to the standard procedure aboveand was filtered directly from the reaction mixture.

The synthetic route of 485-71-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Tao; Scalabrino, Gaia; Frankish, Neil; Sheridan, Helen; Molecules; vol. 23; 7; (2018);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The respective diketo compound and 1, 10-phenanthroline-5, 6-diamine were dissolved in methanol followed by catalytic amountof acetic acid and the mixture was refluxed for 5-6 h. The mixturewas cooled to room temperature and the solid separated wasfiltered, washed with small amount of cold methanol followed byhexane and dried well to get red colored product.

168646-54-6, The synthetic route of 168646-54-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kothavale, Shantaram; Sekar, Nagaiyan; Dyes and Pigments; vol. 136; (2017); p. 31 – 45;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,787-70-2

General procedure: A mixture of acid (0.2 mmol), alcohol (0.6 mmol) and GO (50 wt%, calculated with the mass of acid) in ethyl alcohol or DCE (1 mL) was placed in a test tube equipped with a magnetic stirring bar. The mixture was stirred at 100 C for 24 h. After the reaction was finished, filtered the GO, solvent was removed, and the residue was separated by column chromatography to give the pure sample.

The synthetic route of 787-70-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Letter; Chen, Zhengwang; Wen, Yuelu; Fu, Yejuan; Chen, Hai; Ye, Min; Luo, Guotian; Synlett; vol. 28; 8; (2017); p. 981 – 985;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI