Tag: M.W:200-300

10108-87-9, N,N,N-Trimethyldecan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In the next step, alkyltrimethylammonium chlorides3a-c as prepared above (0.07 mol) were dissolved in ethanol(20 mL) and weighed precisely. The exact amount ofchloride ions was determined by AgNO3 titration of smallsamples and the required equimolar amounts of carboxylicacids 4a-c were weighted and added. 95% of KOH, requiredfor neutralization, was weighed as solid pellets. Afterall of the added solid KOH dissolved and KCl precipitated(1 hour), the remaining KOH was titrated as anapproximate 0.25 M solution of KOH in ethanol until potentialof glass electrode dropped below -250 mV whichwas previously determined as the potential of the inflectionpoint. Solutions were filtered to separate the filtrate containingthe products from the precipitated KCl. Filtrateswere concentrated under reduced pressure subsequentlyprecipitating more KCl which was filtered to obtain filtrate containing desired alkyltrimethylammonium carboxylates5a-e in quantitative yields. Solutions were dried first underreduced pressure and followed by high vacuum. However,due to increased solubility of KCl in the presence of theproducts up to 3% of KCl remains in the final product asdetermined by AgNO3 titration and TG analysis.

10108-87-9, As the paragraph descriping shows that 10108-87-9 is playing an increasingly important role.

Reference£º
Article; ?tanfel, Ur?a; ?ener, Bo?tjan; Be?ter-Roga?, Marija; Ko?mrlj, Janez; Medo?, ?iga; Virant, Miha; Acta Chimica Slovenica; vol. 67; 1; (2020); p. 270 – 275;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

29176-55-4, 2,9-Dichloro-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried Schlenk flask was evacuated and back-filled with argon three times. (Hetero)aryl (di)halide (1 equiv), base (1.5 equiv per halogen) and a solution of SPO (1.2 equiv per halogen) in anhydrous solvent (5 mL/mmol per halogen) were added to the flask. The solution was bubbled with argon for 10 min and Pd(OAc)2 (1 mol% per halogen) and ferrocene-based bidentate phosphine ligand (2 mol% per halogen) were added to the flask simultaneously [2.5 mol% Pd(OAc)2 per halogen and 5 mol% dppf per halogen for compounds 2j, 2l, 2r, 2t, 2w]. The resulting mixture was heated at the indicated temperature for the given time. Workup procedures are described below for two different conditions. Final purification of crude products was achieved by column chromatography on silica gel (40-60 mum) using CH2Cl2-MeOH as eluent. Reaction scale and yields are shown in Table 1 (2a-w), Scheme 1 (3a-h) and Scheme 2 (4a-g). Notice that all compounds with two phosphine oxide groups are beige-to-brown solids or slowly solidifying viscous brown oils. Conditions I: ligand: dppf, solvent: DMF, base: Cs2CO3 (2d-n, 2q, 2r, 2t-w, 4a-g) or K2CO3 (3a-h), temperature: 120 C, time: 7 h (20 h for 2j, 2l, 2r, 2w). Workup: after cooling, the reaction mixture was poured into a fourfold excess of brine. The mixture was extracted three times with CH2Cl2 (40 mL/mmol each). The combined organic layers were washed with brine to remove traces of DMF, dried over Na2SO4 and then evaporated to dryness. Conditions II: ligand: dippf, solvent: toluene, base: t-BuOK, temperature: 110 C, time: 7 h. Workup: after cooling, the reaction mixture was evaporated to dryness. Then, the mixture was diluted with CH2Cl2 (40 mL/mmol) and washed with water and brine (40 mL/mmol). The organic layer was dried over Na2SO4 and the CH2Cl2 was removed under reduced pressure., 29176-55-4

29176-55-4 2,9-Dichloro-1,10-phenanthroline 355196, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Zakirova, Gladis G.; Mladentsev, Dmitrii Yu.; Borisova, Nataliya E.; Synthesis; vol. 51; 11; (2019); p. 2379 – 2386;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,787-70-2

A mixture of Co(NO3)26H2O (0.2 mmol, 58.2 mg), 1,3-bip(0.20 mmol, 35.2 mg), NaOH(0.2 mmol, 8 mg) and H2bpdc(0.20 mmol, 58.2 mg) in DMF-H2O (6 mL, V:V 1:1) binary solventwas placed in a 25 mL Telfon-lined stainless steel container, whichwas heated to 150 C for 3 days, and then cooled to room temperatureover 24 h. Purple block crystals of 1 were collected. Yield:54% based on Cobalt. Elemental analysis (%): calcd for C30H25CoN4O6(Mr 596.47): C 60.36, H 4.19, N 9.39; found: C60.23, H4.12, N 9.81. IR (cm1): 3446(w), 3125(m), 2928(w), 2760(w),1698(s), 1607(s), 1524(s), 1386(s), 1250(s), 1106(m), 947(w), and765(m).

The synthetic route of 787-70-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lu, Jiu-Fu; Wang, Min-Zhen; Liu, Zhi-Hong; Journal of Molecular Structure; vol. 1098; (2015); p. 41 – 46;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1,10-phenanthroline-5,6-diamine (1 mmol), 2,3-dihydroxybenzaldehyde (1 mmol) and EtOH (10 mL) was heated at 70-80 ¡ãC for 24 h. The reaction mixture was cooled to room temperature, dried and concentrated in vacuo. Yield: 89percent. Anal. Calcd for C19H12N4O2: C, 69.51; H, 3.68; N, 17.06. Found: C, 69.39; H, 3.72; N, 17.10. ESI-MS: 328 ([Mr+H]+). 1H NMR (300 MHz, CD3OD-d6): delta 8.91 (d, J = 9.0 Hz, 2H), 8.52 (d, J = 9.0 Hz, 2H), 8.03 (t, J = 8.1 Hz, 2H), 7.22 (d, J = 7.2 Hz, 2H,), 7.12 (d, J = 6.9 Hz, 2H,), 5.79 (s, 1H). 13C NMR (300 MHz, CD3OD-d6): delta 165.19, 160.92, 154.56, 150.56, 143.36, 141.25, 138.11, 134.75, 133.58, 133.24, 131.56, 127.85, 125.56, 124.36, 123.78, 122.56, 121.45, 120.21.

168646-54-6, As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Article; Zhang, Pingyu; Huang, Wenxiu; Wang, Yi; Li, Haihang; Liang, Chunmei; He, Chuanxin; Wang, Haitao; Zhang, Qianling; Inorganica Chimica Acta; vol. 469; (2018); p. 593 – 599;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-91-5,2,2′-Biquinoline,as a common compound, the synthetic route is as follows.

To a solution of cis-[Pt(p-MeC6H4)2(SMe2)2] (0.040 g, 0.078 mmol) in acetone (6 mL) was added a solution of biquinoline (0.020 g, 0.078 mmol) in acetone (6 mL) and the mixture was stirred for 2 h. The solvent was evaporated and a red precipitate product separated and washed twice with n-hexane. Then, the precipitate was dried in vacuum. (Yield: 84%), red, m.p: 160 C (decomp.), Anal. Calc. for [C32H26N2Pt] (1): (M.W: 633.654), C, 60.66; H, 4.14; N, 4.42%. Found: C, 60.09; H, 4.25; N, 4.17%; IR (KBr, y/cm1): (C]C) and (C]N) 1594sh, 1508sh, 1481s, 1431w, (CeH) 815sh, 800s, 746w, (MCl) 509w. 1H NMR (400 MHz, DMSO-d6, d/ppm): 2.17 (6H, s, C6H5CH3), 6.66 (4H, d, 3J(HoHm) 7.60 Hz, 7.23 (d, 4H, 3J(HmHo) 8.00 Hz, 7.29 (3J(PtHo) 17.21 Hz), 8.88 (d, 2H, 3J(H3H4) 8.40 Hz, H3 and H30 of biq), 8.63 (d, 2H, 3J(H4H3) 8.80 Hz, H4 and H40 of biq), 8.33 (dd, 2H, 3J(H8H7) 8.80 Hz, 3J(H8H6) 8.80 Hz, H8 and H80 of biq), 7.86 (d, 2H, 3J(H5H6) 8.00 Hz, H5 and H50 of biq), 7.51 (t, 2H, 3J(H6H5), 3J(H6H7) 16.0 Hz, H6 and H60 of biq). 7.61 (t, 2H, 3J(H7H6), 3J(H7H8) 16.81 Hz, H7 and H70 of biq)., 119-91-5

The synthetic route of 119-91-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shafaatian, Bita; Heidari, Bahareh; Journal of Organometallic Chemistry; vol. 780; (2015); p. 34 – 42;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6813-38-3,[2,2′-Bipyridine]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.,6813-38-3

Weigh 4,4′-dicarboxy-2,2′-bipyridine 500mg (2.05mmol) was added to the reaction flask, 100mL of methanol was added, 8mL of concentrated sulfuric acid was slowly added dropwise and stirred at 105 for 12h. After the reaction was completed and cooled to room temperature, the reaction was added to 500 mL of water, and the pH was adjusted to 9 using saturated NaOH solution. After the pH was adjusted, 200 mL of dichloromethane solution was added and allowed to stand still. At this time, a white flocculent precipitate was formed and the supernatant was poured out. The lower layer was extracted with dichloromethane and water (3 ¡Á 100 mL), the organic phase was extracted and dried to give the product , Yield 76%.

As the paragraph descriping shows that 6813-38-3 is playing an increasingly important role.

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Patent; Nanjing University of Posts and Telecommunications; Zhang Yin; Zhang Taiwei; Sun Guanglan; Gao Pengli; Chen Xiaojiao; Zhao Qiang; Liu Shujuan; Huang Wei; (16 pag.)CN107417737; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

29176-55-4, 2,9-Dichloro-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of E-l-(6-methyl-pyridin-2-yl)-ethanone-O-r3-(9-chloro-rif101phenanthrolin- 2-yl)-prop-2-ynyl1-oxime2,9-Dichloro-[l,10]phenanthroline (0.46 g) and E-l-(6-methyl-pyridin-2-yl)-ethanone-0- prop-2-ynyl-oxime (382 mg) were dissolved in THF (5 ml_). Diisopropylamine (1.88 g), dichlorobis (triphenylphospine)palladium(II) (57 mg) and copper(I) iodide (58 mg) were added. After stirring for 3h at 55C the reaction mixture was poured into water, extracted with ethyl acetate and washed with brine. The organic phase was dried over sodium sulfate, concentrated and purified by chromatography over silica to give l-(6-Methyl-pyridin-2-yl ethanone-O-[3-(9-chloro-[l,10]phenanthrolin-2-yl)-prop-2-ynyl]-oxime as a brown solid., 29176-55-4

The synthetic route of 29176-55-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; TRAH, Stephan; ZAMBACH, Werner; STIERLI, Daniel; NEBEL, Kurt; BORTOLATO, Andrea; WO2012/62844; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

29841-69-8, (1S,2S)-(-)-1,2-Diphenylethylenediamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (1R, 2R)-N-p-styrenesulfonyl-1,2-diphenylethylenediamine was synthesized as follows: 1g of (1R, 2R)-1,2-diphenylethylenediamine (4.71mmol) was dissolved in 20mL of CH2Cl2 in the presence of excessive of triethylamine and cooled to 0C, followed by the slow addition of 5mL of CH2Cl2 solution containing 1g of p-styrenesulfonyl chloride (4.78mmol), and stirred at room temperature overnight. The solution was washed with 5% NaOH aqueous solution, dried with MgSO4, and evaporated under vacuum to remove the solvent. The obtained solid was dissolved in diethyl ether, followed by the addition of 1mL of concentrated HCl (37wt%). The formed white precipitated was filtrated, treated with 5% NaOH aqueous, and then extracted with CH2Cl2 for 3 times. The combined organic phase was washed thoroughly with brine and dried over with MgSO4. The solvent was removed under vacuum and 1.28g of light yellow solid (72% yield) was obtained, which was denoted as V-TsDPEN [11]. 1H NMR (400MHz, DMSO-d6, 298K, TMS): delta6.64-7.38 (m, 14H), 6.64-6.67 (m, 1H), 5.87 (d, 1H, J=16.8Hz), 5.35 (d, 1H, J=11.2Hz), 4.33 (d, 1H, J=7.2Hz), 3.95 (d, 1H, J=6.6Hz) ppm., 29841-69-8

As the paragraph descriping shows that 29841-69-8 is playing an increasingly important role.

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Article; Sun, Qi; Jin, Yinying; Zhu, Longfeng; Wang, Liang; Meng, Xiangju; Xiao, Feng-Shou; Nano Today; vol. 8; 4; (2013); p. 342 – 350;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

18511-72-3, 4,4-dinitro-2,2-Bipyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2,2′-bipyridine (0.025 g, 0.16 mmol) was dissolved in DCM:MeOH 2:1 (6 mL) and [Ir(pyba)2(Cl)]2 (0.100 g, 0.08 mmol) was added. The mixture was heated at reflux under nitrogen atmosphere,in the dark. After 6 h, the yellow solution was cooled to room temperature. The crude solid was purified by column on silicaeluted with MeCN:H2O:KNO3 7:1:0.5. The yellow fractionwas driedunder vacuum, redissolved in acetonitrile and filtered. The solutionwas dried again and the solidwas dissolved in a minimal amount ofmethanol and NH4PF6 (130 mg, 0.9 mmol) was added allowed tostir overnight. The solution was left in the fridge for two hours,recrystallised with ether and then filtered on sintered glass. Ayellow powder was collected by filtration. (42 mg, yield 30%), 18511-72-3

18511-72-3 4,4-dinitro-2,2-Bipyridine 11519563, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Sinopoli, Alessandro; Wood, Christopher J.; Gibson, Elizabeth A.; Elliott, Paul I.P.; Dyes and Pigments; vol. 140; (2017); p. 269 – 277;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-91-5,2,2′-Biquinoline,as a common compound, the synthetic route is as follows.

Under argon atmosphere, 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (66.0 mg, 0.114 mmol) was added to 4 mL of the solution of silver(I) tetrafluoroborate (22.2 mg, 0.114 mmol) in dichloromethane, and the mixture was stirred at room temperature for 15 minutes. Then, 2,2′-biquinoline (32.2 mg, 0.125 mmol) was added to the reaction solution, which was heated to reflux with stirring for one hour. The reaction solution was filtrated, and the filtrate was subjected to recrystallization by slow diffusion of dichloromethane-ether and dried to provide 103 mg of the complex of the yellow crystal. [Show Image] The NMR data of the obtained complex is provided below. 1H NMR (300 MHz, CDCl3) delta 8.79 (d, J = 8.7 Hz, 2H), 8.68 (d, J = 8.7 Hz, 2H), 7.92 (d, J = 8.2 Hz, 2H), 7.82 (d, J = 8.2 Hz, 2H), 7.73 (d, J = 6.8 Hz, 2H), 7.48 (t, J = 7.4 Hz, 2H), 7.28-7.23 (m, 6H), 7.13-7.06 (m, 10H), 7.02-6.96 (m, 8H), 6.54-6.50 (m, 2H), 1.85 (s, 6H); 31P NMR (122 MHz, CDCl3) delta -4.6 (d, J (31P-107Ag, 109Ag) = 361, 417Hz). The composition of the obtained complex was determined according to the same method as in Example 15. The present complex corresponds to the above composition formula (5)., 119-91-5

As the paragraph descriping shows that 119-91-5 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI