Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3779-42-8,3-Bromo-N,N,N-trimethylpropan-1-aminium bromide,as a common compound, the synthetic route is as follows.

Compound 30 (100 mg, 0.12 mmol) is dissolved and K2CO3 (230 mg, 1.7 mmol) is suspended in DMF (30 mL). To the vigorously-stirred mixture a solution of (1-BROMOPROPYL)-TRIMETHYLAMMONIUM bromide (0.3 g, 16.6 mmol) in DMF (10 mL) is added dropwise at 50C during 30 mins and the mixture is heated for 18 h. After removal of DMF under reduced pressure, the residue obtained is dissolved in methanol (5 mL) and filtered through a pad of silica gel (depth 2 CM) supported on a steel frit (diameter 3.5 CM). After washing the pad with methanol (ca. 500 mL) it is eluted with acetic acid: methanol: water (3: 2: 1, by vol. ). After evaporation of solvent from appropriate combined fractions under reduced pressure, the residue is purified by chromatography on a column (2.5 x 40 CM) of Sephadex LH-20 eluting with n-butanol: water: acetic acid (5: 4: 1, by vol. , upper phase). After removal of solvent under reduced pressure from the eluate, the residue obtained is dissolved in methanol and the solution is passed through a short column (3.5 x 20 cm) of anion exchange resin (Amberlite IRA 400, chloride form). Evaporation of solvent from the eluate gives the product which is dried under high vacuum. 1H-NMR : aH (300MHZ, CD30D) : 0.75-0. 80 (m, 3 H), 1.00-1. 40 (m, 18 H), 1.60- 1.80 (bs, 2 H), 2.25-2. 40 (bs, 6 H), 3.29 (bs, 27 H), 3.40-3. 60 (m, 6 H), 3.90-4. 00 (m, 2 H), 4.05-4. 25 (m, 6 H), 7.10-7. 20,7. 25-7.40, 7.60-7. 80, 7.80-7. 90 (4 x m, 16H), 8.70-9. 00 (bs, 8 H)., 3779-42-8

The synthetic route of 3779-42-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DESTINY PHARMA LIMITED; SOLVIAS AG; WO2004/56828; (2004); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

In a 1000 ml three-vial bottle,Under nitrogen protection,Add 200 ml of anhydrous ethanol,200 ml of toluene,21 g (0.1 mol) of 1,10-phenanthroline-5,6-diamine, 10.6 g (0.1 mol) of benzaldehyde,1 ml glacial acetic acid,After the addition, the temperature was gradually raised to reflux for 6 hours.After cooling, the reaction solution was concentrated to dryness under reduced pressure.The resulting solid was recrystallized from a mixed solvent of chloroform and ethanol.27.1 g of 2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline was obtained.Yield 91.55percent.

168646-54-6, 168646-54-6 5,6-Diamino-1,10-phenanthroline 10910805, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Li Xianwei; (29 pag.)CN107973811; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (Part 1) To a stirred solution of Cinchona alkaloid (either Quinine, Quinidine, Cinchonine or Cinchonidine) (1 equiv.) in THF (0.1 M) was added the required arylmethyl halide compound (1.2 equiv.) at room temperature. The reaction mixture was refluxed overnight, cooled to room temperature and all volatiles were removed invacuo. The residue was then dissolved in CH2Cl2 (typically 2 mL for 1 mmol of starting material) and the resulting solution was added dropwise onto Et2O (typically 30 mL for 1 mmol of starting material) with vigorous stirring. The resulting precipitate was then filtered, washed thoroughly with Et2O, and further dried under high vacuum for 2 hours, yielding the intermediate alcohol product in an excellent yield. (Part2) This product (1 equiv.) was dissolved in CH2Cl2 (0.2 M). Methyl iodide (3 equiv.) and an aqueous sodium hydroxide solution (50 %w, 5 equiv.) were successively added at room temperature. The reaction mixturewas stirred at room temperature for 4 h, before water (typically 20 mL for 1 mmol of starting material) was added to quench the reaction. The organic layer was separated and the aqueous layer was extracted with CH2Cl2. The combined organic extracts were dried over Na2SO4, and concentrated in vacuo (N.B: washing with brine is prohibited to avoid the I/Cl anion exchange). Purification by column chromatography on silica gel, eluting with MeOH/Acetone/CH2Cl2 (0:10:90 to 10:10:90), afforded the desired Cinchona alkaloid quaternary ammonium salt in a moderate to excellent yield.

485-71-2, As the paragraph descriping shows that 485-71-2 is playing an increasingly important role.

Reference£º
Article; Antien, Kevin; Viault, Guillaume; Pouysegu, Laurent; Peixoto, Philippe A.; Quideau, Stephane; Tetrahedron; vol. 73; 26; (2017); p. 3684 – 3690;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,787-70-2

Step-1 : Synthesis of bis(2,5-dioxopyrrolidin-l-yl) biphenyl-4,4′-dicarboxylate (3399) [1182] To a stirred solution of biphenyl-4,4′-dicarboxylic acid (500 mg, 2.06 mmol) in 10 mL of DMF was added N-hydroxysuccinimide (594 mg, 5.16 mmol) and (3400) dicyclohexylcarbodiimide (1.06 g, 5.16 mmol) at 0C and the mixture stirred at RT overnight. The reaction mixture was filtered and the filtered cake was washed with EtOAc. The washings and filtrate were combined, washed with brine solution (3×20 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford a crude product that was dissolved in DCM and again filtered. The DCM layer was concentrated under reduced pressure to afford desired product (600 mg).

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Patent; MEDIVATION TECHNOLOGIES, INC.; HUNG, David; CHAKRAVARTY, Sarvajit; RAI, Roopa; BERNALES, Sebastian; SATHE, Balaji Dashrath; URETA, Gonzalo; MCCULLAGH, Emma; WO2015/116707; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17217-57-1,4,4′-Dimethoxy-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

General procedure: Dried RuCl3 (0.20 g, 0.96 mmol) was dissolvedin dipropylene glycol (10 mL) and deionized water (1 mL).The solution was refluxed until the metal salt was dissolved,obtaining a dark green solution. Bipyridine (0.469 g; 3.0 mmol) wasadded, resulting in a brown solution. Ascorbic acid (0.177 g,1.0 mmol) was then added and the solution refluxed for 20 min at250 C, the brown colour changing to red. After cooling, the solutionwas diluted to 40 mL and the pH adjusted to 8 by addition of afew drops of NaOH solution (2.5 M). NaBF4 (4.0 g, 36 mmol) wasadded and the solution cooled on ice. After vacuum filtration,washing with cold water, and drying, 0.329 g [Ru(bpy)3](BF4)2product was obtained., 17217-57-1

The synthetic route of 17217-57-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; van der Westhuizen, Deidre; von Eschwege, Karel G.; Conradie, Jeanet; Electrochimica Acta; vol. 320; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.

Weigh 4,4′-biphthalic acid (10.00g, 41.3mmol) and silver sulfate (28.00g, 89.7mmol) into a 500mL double-necked flask, then add 250mL concentrated sulfuric acid and at room temperature Stir, then weigh the iodine element (23.00g, 90.5mmol) and add it to the double-necked flask, and cover the double-necked flask with tin foil for light-shielding treatment. The reaction takes place at room temperature for 1 hour, then the temperature is raised to 80 C, and the reaction is continued for 24 hours . After the reaction was completed, the reaction solution was cooled to room temperature, and the reaction solution in the double-necked flask was poured into 500 mL of ice water, resulting in a large amount of yellow precipitate, and the crude product was obtained by filtration. The above crude product was added to a 500 mL single-necked flask, and 300 mL of methanol was added. After stirring, 5 mL of concentrated sulfuric acid was slowly added dropwise, the temperature was raised to 100 C, the reaction was refluxed for 12 hours, cooled to room temperature, and the organic solvent was distilled off under reduced pressure. Saturated brine, and extracted three times with 500 mL of dichloromethane. The organic phase was dried over anhydrous magnesium sulfate, and the organic solvent was distilled off under reduced pressure. The organic solvent was purified by chromatography using methylene chloride as the eluent. 18.35 g of dimethyl ‘-diiodo-4,4’-diphthalate, that is, compound a, with a yield of 85.1% (based on dimethyl diphthalate)., 787-70-2

787-70-2 [1,1′-Biphenyl]-4,4′-dicarboxylic acid 13084, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Tongji University; Zhang Ronghua; Liu Changwei; Li Liangchun; (9 pag.)CN110483333; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4479-74-7,2,2-Bipyridine-6,6-dicarboxylic Acid,as a common compound, the synthetic route is as follows.

General procedure: A mixture of Tb(NO3)3¡¤6H2O (0.045 g, 0.10 mmol), H2bpdc (0.024 g, 0.10 mmol) in distilled water (10 mL) that adjusted the pH value to 2.5 with 0.5 mol L-1 NaOH aqueous solution. It was then sealed in a 25 mL Teflon reactor and heated at 160 C for 72 h, and then cooled to ambient temperature at a rate of ca.2 C h-1 to give colorless block crystals of 7, yield: 57% based on H2bpdc.

4479-74-7, As the paragraph descriping shows that 4479-74-7 is playing an increasingly important role.

Reference£º
Article; Ren, Ya-Lan; Wang, Fei; Hu, Huai-Ming; Chang, Zhuguo; Yang, Meng-Lin; Xue, Ganglin; Inorganica Chimica Acta; vol. 434; (2015); p. 104 – 112;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4392-87-4,4392-87-4, [2,2′-Bipyridine]-6-carboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of H2bpdc, Fe(NO3)2¡¤9H2O and 10 mL H2O was put in a 15-mL Teflon-lined autoclave. After sonication, the mixture was kept under autogenous pressure at 160 C for 3 days and then cooled to room temperature at 10 C h-1.

As the paragraph descriping shows that 4392-87-4 is playing an increasingly important role.

Reference£º
Article; Xie, Jianhui; Zheng, Baocheng; Li, Bing; Transition Metal Chemistry; vol. 44; 5; (2019); p. 425 – 430;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

554-95-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.554-95-0,Benzene-1,3,5-tricarboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Reaction of AgNO3 (33.4 mg, 0.2 mmol), pyridazine (pdz) (16.0 mg, 0.2 mmol) and 1,3,5-benzene tricarboxylic (H3btc) (44.2 mg, 0.2 mmol) took place in H2O-DMF (N,N-Dimethylformamide) solvents (6 ml, v/v = 1:1) in the presence of ammonia (0.5 mL, 14 M) under ultrasonic treatment (160 W, 40 kHz,30 min) at 40 C. The resultant colourless solution was allowed slowly to evaporate at room temperature in the dark. The yellow crystals of complex 1 were obtained after several days.The crystals were isolated by filtration and washed by deionized water and ethanol and dried in the air. Yield based on Ag is 88% .Elemental analysis: Anal. Calc. for Ag6C26H14N4O12: C, 25.563; H,1.155; N, 4.586. Found: C, 25.37; H, 1.19; N, 4.65%. Selected IR peaks (cm1): 3283 (s), 2264 (w), 1863 (w), 1614 (s), 1557 (s),1417 (s), 1360 (s), 1099 (m), 1060 (w), 972 (w), 920 (w), 767 (s), 716 (s), 660 (w), 514 (m), 455 (w).

As the paragraph descriping shows that 554-95-0 is playing an increasingly important role.

Reference£º
Article; Wang, Dan-Feng; Zhang, Ting; Dai, Si-Min; Huang, Rong-Bin; Zheng, Lan-Sun; Inorganica Chimica Acta; vol. 423; PART A; (2014); p. 193 – 200;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 2 or 3 (0.50 mmol), the corresponding acids RCOOH (0.60 mmol),DCC (0.60 mmol), DMAP (0.1 mmol) in dry dichloromethane (15 mL) was stirred atroom temperature. When the reaction was completed, and checked by TLC, the mixturewas filtered to remove urea from the reaction, and the filtrate was diluted bydichloromethane (45 mL). Subsequently, the diluted organic phase was washed bysaturated aqueous NaHCO3 (30 mL), and brine (30 mL), dried over anhydrousNa2SO4, concentrated in vacuo, and purified by CC to give the pure 9R/S-acyloxyderivatives of cinchonidine and cinchonine 5a-j,l-o and 6a,c,e-o [17-19]. The dataof target compounds are shown as follows.

485-71-2, As the paragraph descriping shows that 485-71-2 is playing an increasingly important role.

Reference£º
Article; Che, Zhi-Ping; Chen, Gen-Qiang; Jiang, Jia; Lin, Xiao-Min; Liu, Sheng-Ming; Sun, Di; Tian, Yue-E; Yang, Jin-Ming; Zhang, Song; Journal of Asian Natural Products Research; (2020);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI