Tag: M.W:200-300

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The phase-transfer catalysts (C1-C11) were synthesized according to the proceduresbelow. To a solution of cinchonidine (1.00 g, 3.4 mmol) in THF (50 mL) was addedthe aryl benzyl bromides (3.4 mmol). The mixture was heated for 6-8 h at reflux.After cooling to room temperature, the mixture was poured into MTBE (150 mL)under stirring. The precipitated solid was filtrated and recrystallized fromCH3OH/MTBE to afford C1-C11

485-71-2, 485-71-2 Cinchonidine 101744, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Li, Ruipeng; Liu, Zhenren; Chen, Liang; Pan, Jing; Zhou, Weicheng; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1421 – 1427;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103946-54-9,4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid,as a common compound, the synthetic route is as follows.

[(Cp*)Ir(mu-Cl)Cl]2 (39.8 mg, 0.05 mmol) was dissolved in methanol(20 mL) followed by addition of the 4-methyl-4?-carboxy-2,2?-bipyridine ligand (21.4 mg, 0.10 mmol). The mixture was stirred at313 K overnight. The final yellow solution was filtered, concentratedand NH4PF6 (163 mg, 1.0 mmol) was added to the solution. This solutionwas kept at 277 K overnight. The yellow precipitate was collectedby filtration and dried under vacuum. Yield 66 mg, 91%; 1H NMR(400 MHz, d4-MeOD, 298 K): delta 9.11 (d, 1H, J = 5.8 Hz), 9.00 (s, 1H),8.81 (d, 1H, J=5.8 Hz), 8.61 (s, 1H), 8.26 (d, 1H, J=5.8 Hz), 7.71 (d,1H, J = 6.1 Hz), 2.70 (s, 3H), 1.72 (s, 15H); 13C NMR (125 MHz, d4-MeOD, 298 K): 165.79, 158.15, 155.99, 155.08, 154.10, 152.47,143.72, 131.21, 129.19, 126.65, 124.58, 91.28, 21.39, 8.67; high resolutionESI-MS m/z calcd for [(M-PF6-H)+Na]+ 599.1040, found599.1038.

103946-54-9, As the paragraph descriping shows that 103946-54-9 is playing an increasingly important role.

Reference£º
Article; Zhang, Wen-Ying; Banerjee, Samya; Imberti, Cinzia; Clarkson, Guy J.; Wang, Qian; Zhong, Qian; Young, Lawrence S.; Romero-Canelon, Isolda; Zeng, Musheng; Habtemariam, Abraha; Sadler, Peter J.; Inorganica Chimica Acta; vol. 503; (2020);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

200 g (0.68 mol) of tetra-n-butylphosphonium chloride,In an aqueous solution containing 80% of potassium formate was added 84 g (1.00 mol)Was added to the solution.In this state, since two phases were separated, water was added to make a homogeneous solution.This solution was concentrated under reduced pressure at 100 C.,Crystals of potassium chloride precipitated.The crystals were hot-filtered, and the filtrate containing the ionic liquid was recovered.The filtrate was dried under reduced pressure with an oil rotary pump to recover the regenerated ionic liquid.When this ionic liquid was analyzed by the Mohr method, the chloride ion concentration was 0.37 mol / kg.That is, it was found that 89% of the chloride ion in the model degraded ionic liquid was removed and replaced with formate ion.

2304-30-5, 2304-30-5 Tetrabutylphosphonium chloride 75311, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; The Doshisha; Yasaka, Yoshiro; (11 pag.)JP2015/113335; (2015); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.

787-70-2, Into a vessel was placed about 10 ml of dimethyl formamide (Fisher, 99%) which contained about 0.1 millimole of 4,4′ bipyridine under ambient atmospheric conditions. Into this, with stirring at ambient temperature (about 25 C.), was added about 0.3 millimoles of the zinc precursor polymer. Stirring was continued until the mixture was homogeneous, (about 10 minutes). The mixture was transferred in air to a Parr acid digestion bomb which was then sealed. The mixture was heated to 150 C. and held at that temperature for 3 days, yielding crystals of the zinc polymeric compound in about 94% yield based on the weight of the zinc precursor polymer compound. [0113] Synthesis of the Zinc Precursor Polymer [0114] The zinc precursor polymer compound used in the synthesis of the zinc polymeric compound of Example 3 was itself synthesized according to the following procedure. At room temperature (about 25 C.), into a vessel containing about 5.5 mL of a 0.01 molar bis-sodium biphenyl-4,4′-dicarboxylate aqueous solution (about 0.55 millimoles of the dicarboxylate, prepared as described below) was placed about 10 mL of a 0.1 molar aqueous Zn(NO3)2 solution (about 1.0 millimoles of zinc nitrate hexahydrate (Fisher) dissolved in 10 ml of deionized water). This immediately precipitated a mass of the zinc polymer precursor compound (stiochiometric formula [Zn(bpdc)(H2O)2].(H2O)], where ?bpdc? is biphenyl-4,4′-dicarboxylate). The precipitate was washed with distilled water and used as prepared. Yield was about 90% based on starting zinc nitrate. [0115] Bis-sodium-biphenyl-4,4′-dicarboxylate solution was prepared as described above in the preparation of the first cobalt precursor polymer, as described above in Example 1.

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Patent; Li, Jing; Pan, Long; Huang, Xiaoying; US2004/110950; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4479-74-7, 2,2-Bipyridine-6,6-dicarboxylic Acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of Gd(NO3)3¡¤6H2O (0.023g, 0.05mmol), H2bpdc (0.024g, 0.10mmol) in distilled water (10mL) that adjusted the pH value to 5.5 with 0.5molL-1 NaOH aqueous solution was placed in a Teflon-lined stainless steel vessel (25mL), heated to 160C for 72h and then cooled to room temperature at a rate of 5C/h. The colorless crystalline product of 1 was obtained (yield: 35% based on H2bpdc)., 4479-74-7

The synthetic route of 4479-74-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ren, Ya-Lan; Wang, Fei; Hu, Huai-Ming; Chang, Zhuguo; Yang, Meng-Lin; Xue, Ganglin; Inorganica Chimica Acta; vol. 434; (2015); p. 104 – 112;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2083-68-3, Trimethyloctylammonium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In these experiments, quaternary ammonium bromides with C8-C18alkane chains were used as precursors of theophylline-based ILs (TILs).Octyltrimethylammonium bromide and decyltrimethylammoniumbromide were obtained from Fluka (Ronkonkoma, NY, USA).Dodecyltrimethylammonium bromide, tetradecyltrimethylammoniumbromide, and hexadecyltrimethylammonium bromide were obtainedfrom Acros Organics. Octadecyltrimethylammonium bromide wasobtained from Sigma-Aldrich (St. Louis, MO, USA). All chemicals were ofanalytical grade. The TILs were synthesized as described previously [10].Briefly, 0.05 mol of alkyltrimethylammonium bromide was dissolved inmethanol and stoichiometric amount of potassium hydroxide in methanolwas added. The solution was stirred for 5 min at 25 C and filteredin order to remove precipitated KBr. Next, the stoichiometric amount oftheophylline in substantia was added. The obtained solution was stirredfor 15 min, filtered again and the solvent was evaporated using rotaryevaporator. The product was dissolved in acetone and filtered to removeresidual KBr. Then, the acetone was evaporated and the product wasdried. The purity and concentration of obtained products in water solutionduring the next experiments were determined by UV spectroscopy(G10S UV-Vis, Thermo Fisher Scientific, Madison, WI, USA) using thecalibration curve. The investigated ILs exhibit a characteristic peak at lambda=269 nm. The theophylline-based ILs were designated as C8T-C18T dependingon the number of carbon atoms in the alkyl chain.

2083-68-3, As the paragraph descriping shows that 2083-68-3 is playing an increasingly important role.

Reference£º
Article; Borkowski, Andrzej; Kowalczyk, Pawe?; Czerwonka, Grzegorz; Cie?la, Jolanta; C?apa, Tomasz; Misiewicz, Anna; Szala, Mateusz; Drabik, Marcin; Journal of Molecular Liquids; vol. 246; (2017); p. 282 – 289;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3779-42-8,3-Bromo-N,N,N-trimethylpropan-1-aminium bromide,as a common compound, the synthetic route is as follows.

COMPOUKD 29; 5J0-bis-[4-(3-Trimethylammonio-propyloxy)-phenyl]-15,20-bis-(4- undecyloxy-phenyl)-porphyrin dichloride; Compound 14 (50 mg, 0.05 mmol) is dissolved and K2CO3 (150 mg, 1.1 mmol) is suspended in DMF (30 mL). To the vigorously- stirred mixture a solution of (l-bromopropyl)-trimethylammonium bromide (0.3 g, 16.6 mmol) in DMF (10 mL) is added dropwise at 500C and the mixture is heated for 18 h. After removal of DMF under high vacuum, the residue obtained is dissolved in methanol (5 mL) and filtered through a pad of silica gel (depth 2 cm) supported on a steel frit (diameter 3.5 cm). After washing the pad with methanol (ca. 500 mL) it is eluted with acetic acid:methanol:water (3 :2:1, by vol.). After evaporation of solvent from appropriate combined fractions the residue obtained is purified by chromatography on a column (2.5 x 40 cm) of Sephadex LH-20 eluting with n-butanol:water:acetic acid (5:4: 1, by vol.. upper phase) for further separation from the excess ammonium salt and other by-products. After removal of solvent under reduced pressure the residue obtained is dissolved in methanol and passed through a short column (3.5 x 20 cm) of anion exchange resin (Amberlite IRA 400, chloride form). After evaporation of solvent under reduced pressure, the product is dried under high vacuum.1H-NMR: deltaH (300MHz, CD3OD): 0.80 (t, 3J 7.5 Hz, 6 H), 1.15-1.35 (m, 28 H), 1.35-1.45 (bs, 4 H), 1.70-1.80 (bs, 4 H), 2.30-2.40 (bs, 4 H), 3.15-3.30 (bs, 18 H), 3.65-3.75 (bs5 4 H), 4.00-4.05 (m, 4 H), 4.30-4.40 (bs, 4 H), 7.00-7.15, 7.20-7.30, 7.80-95, 7.95-8.15 (4 x m, 4 x 4 H), 8.60-9.00 (bs, 8 H).

3779-42-8, As the paragraph descriping shows that 3779-42-8 is playing an increasingly important role.

Reference£º
Patent; DESTINY PHARMA LIMITED; WO2006/765; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

114527-28-5, 4-(4′-Methyl-[2,2′-bipyridin]-4-yl)butanoic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of a weak light frequency upconversion triplet sensitizer4 – methyl – 4 – butyric acid – 2,2 – bipyridine and ruthenium trichloride were added to ethylene glycol ether solvent, and the reaction was heated at refluxAfter 12 hours, the solvent was removed and recrystallization was carried out to give tris (4-methyl-4-butyldicarboxylic acid 2,2-bipyridyl)ruthenium complex.

114527-28-5, As the paragraph descriping shows that 114527-28-5 is playing an increasingly important role.

Reference£º
Patent; Suzhou University of Science and Technology; Zhou, Yuyang; Ma, Haonan; Wang, Xiaomei; Ye, Changqing; (15 pag.)CN105601560; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

99970-84-0, [2,2′-Bipyridine]-4,4′-dicarbaldehyde is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

99970-84-0, 6-(2′-aminoethyl)-3,6,9-triaza-1(2,6)-pyridinacyclodecaphane (443.2 mg, 1.78 mmol) and 2,2′-bipyridine-4,4′-dicarbaldehyde(198 mg, 0.93 mmol) were dissolved in 40 mL of anhydrous ethanol and the mixture was stirred for 2 h at room temperature. NaBH4(550 mg, 14.5 mmol) was then added and the resulting solution stirred for 2 h at room temperature. The ethanol was removed under reduced pressure. The resulting residue was treated with H2O (10 mL) and extracted with CH2Cl2 (3 ¡Á 20mL). The organic phase was removed at reduced pressure, and the resulting residue was dissolved in ethanol and precipitated as the hydrochloride salt of L3 in 75% yield. mp: N 345 C. 1H NMR (300MHz, D2O): deltaH (ppm)=8.88 (d, J=5.5 Hz, 2H), 8.55 (s, 2H),7.94 (d, J=5.5 Hz, 2H), 7.92 (t, J=8 Hz, 2H), 7.42 (d, J=8 Hz, 4H), 4.60(s, 4H), 4.59 (s, 8H), 3.47 (t, J=8Hz, 4H), 3.26(t, J=5.3Hz, 8H), 3.13 (t,J = 8 Hz, 4H), 2.92 (t, J = 5.3 Hz, 8H). 13C NMR (75.43 MHz, D2O): deltaC(ppm) = 149.4, 148.9, 147.7, 146.1, 139.8, 127.0, 124.3, 122.2, 50.8,50.5, 50.0, 49.5, 45.9, 43.9. Calc for C38H54N12*8HCl*9H2O: C 40.3%, H7.1%,N 14.8%. Found: C 40.4%, H 7.3%, N 14.9%. MS (FAB)m/z 680 [MH]+.

99970-84-0 [2,2′-Bipyridine]-4,4′-dicarbaldehyde 4171663, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Gonzalez-Garcia, Jorge; Martinez-Camarena, Alvar; Verdejo, Begona; Clares, M. Paz; Soriano, Concepcion; Garcia-Espana, Enrique; Jimenez, Hermas R.; Domenech-Carbo, Antonio; Tejero, Roberto; Calvo, Enrique; Brianso-Llort, Laura; Serena, Carolina; Trefler, Sandra; Garcia-Espana, Antonio; Journal of Inorganic Biochemistry; vol. 163; (2016); p. 230 – 239;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4568-71-2,3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride,as a common compound, the synthetic route is as follows.,4568-71-2

(1) Preparation of methyl 4-(2-furyl)-4-oxobutyrate (Compound 26F-A) After 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride (1.0 g, 4 mmols) and triethylamine (2.02 g, 20 mmols) were added to a solution of furfural (4.8 g, 50 mmols) in absolute ethanol (30 ml). The mixture was stirred at room temperature for 40 minutes. Methyl acrylate (5.0 g, 50 mmols) was further added to the mixture followed by heating to reflux for 7 hours. The reaction solution was concentrated in vacuo. The residue obtained was purified by silica gel column chromatography (600 ml, hexane:ethyl acetate=2:1) to give Compound (26F-A) (3430 mg, yield: 37.6percent). 1H-NMR (200 MHz, CDCl3) delta: 2.74 (2H, t, J=6.8 Hz), 3.18 (2H, t, J=6.8 Hz), 6.54 (1H, dd, J=1.7 Hz, 3.6 Hz), 7.23 (1H, dd, J=0.7 Hz, 3.6 Hz), 7.59 (1H, dd, J=0.7 Hz, 1.7 Hz); MS (FAB, POS) m/z: 180 (M+H)+.

The synthetic route of 4568-71-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nippon Kayaku Kabushiki Kaisha; US6384063; (2002); B1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI