Tag: M.W:200-300

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4,7-phenanthroline-5,6-dione (1 eq, 0.096 mol) and 1,10-phenanthroline-5,6-diamine (1.1 eq, 0.106 mol) after mixing, these were added to 300 mL of acetic acid and dissolved, followed by stirring under reflux for 12 hours. Thereafter, the reaction solution was put into distilled water, and the obtained solid was filtered, washed several times with distilled water,the residue was purified by rum chromatography to obtain an A-4 compound (yield: 43percent)., 168646-54-6

The synthetic route of 168646-54-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG Display Co., Ltd.; Hyeong Min-seok; Choi Seul-gi; Lee Tae-yang; (40 pag.)KR2019/42882; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29176-55-4,2,9-Dichloro-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

2,9-Dichloro-1,10-phenanthroline was prepared as described in Bull. Chem. Soc. Jpn. 65, 2007-2009 (1992). 1,2-phenylene [bis (2-methylphenyl)] phosphine was synthesized by the method described in Organometallics, 23, 6077-6079 (2004). Under an argon atmosphere, 1,2-phenylenebis [bis (2-methylphenyl)] phosphine (81.3 mg, 0.6 mmol) was added to a 1 mL solution of silver tetrafluoroborate (I) (31.5 mg, 0.162 mmol) in dichloromethane. 162 mmol), and the mixture was stirred at room temperature for 10 minutes. To the reaction mixture was added 2,9-dichloro-1,10-phenanthroline (46.4 mg, 0.186 mmol), and the mixture was stirred at room temperature for 10 minutes. The reaction solution was filtered, the filtrate was concentrated, recrystallized by slow diffusion with dichloroethane-ether, and dried to obtain 130 mg (yield: 85.2%) of a pale yellow solid complex.

29176-55-4, 29176-55-4 2,9-Dichloro-1,10-phenanthroline 355196, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; KOBAYASHI, NORIFUMI; HIGASHIMURA, HIDEYUKI; (18 pag.)JP5670835; (2015); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

134030-21-0, N1,N2-Dimesitylethane-1,2-diamine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 14 Synthesis of carbene precursor 8 (2-pentafluorophenyl-1,3-bis-(2,4,6-trimethyl-phenyl)-imidazolidine): mesityldiamine (512 mg, 1.7 mmol) was placed into a vial, equipped with a stirbar, with pentafluorobenzaldehyde (340 mg, 1.7 mmol).glacial acetic acid (5 ML) was added and the reaction was stirred at room temperature for 24 h.The acetic acid was removed under reduced pressure and the product was washed several times with cold methanol to afford the product as a white crystalline solid (543 mg, 65%).1H NMR: (400 MHz, CDCl3, 25 C.) delta: 2.2 (s, 12H), 2.3 (s, 6H), 3.5-3.6 (m, 2H), 3.9-3.4 (m, 2H), 6.4 (s, 1H), 6.9 (s, 4H).19F NMR: -136.3–136.4 (m, 1F), -148.6–148.7 (m, 1F), -155.8–155.9 (m, 1F), -163.0–163.3 (m, 2F).

134030-21-0, As the paragraph descriping shows that 134030-21-0 is playing an increasingly important role.

Reference£º
Patent; Hedrick, James Lupton; Kilickiran, Pinar; Nyce, Gregory Walker; Waymouth, Robert M.; US2004/127720; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

168646-54-6, 5,6-Diamino-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen protection,A solution of 5-bromo-1-phenylindole-2,3-dione (Intermediate a) (30.2 g, 0.1 mol) and 1,10-phenanthroline-5,6-diamine (Intermediate b ) (21.0 g, 0.1 mol) was added to 200 mL of absolute ethanol.The reaction was allowed to warm to 70-75 ¡ã C for 24 hours.Reaction is completed, cooled to room temperature after the direct suction filter,The filter cake was rinsed with absolute ethanol and the crude product was crystallized from dichloroethane / absolute ethanol to give a yellow solid,That is the intermediate c, the yield of 70percent.

168646-54-6, As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Patent; Wanrun Pharmaceutical Co., Ltd.; Zhang, Xueheng; Ju, Chengliang; Shi, Yu; Yang, Teng; Chi, Pengli; Yang, Hao; (17 pag.)CN106366083; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3779-42-8,3-Bromo-N,N,N-trimethylpropan-1-aminium bromide,as a common compound, the synthetic route is as follows.

Compound 45 (50 mg, 0.062 mmol) and (3-bromopropyl)- trimethylammonium bromide (162mg, 0.62 mmol, LOEQV.) are dissolved and potassium carbonate (128 mg, 0.93 mmol, 15 eqv. ) is suspended under argon in absolute DMF (30 ML) and the mixture is stirred at 55C for 12 h. The solvent is removed in vacuo at 50C and the residue re- dissolved in a little methanol and applied to a pad of silica (2 cm deep). The unreacted ammonium salts are washed off with methanol (LOOOML). The product is eluted with acetic acid: methanol: water (3: 2: 1 by vol.). The solvents are removed under reduced pressure and the product further purified by chromatography on a column (lOOg) of Sephadex LH-20 eluting with n-butanol: water: acetic acid (4: 5: 1 by vol. , upper phase). The solvents are removed under reduced pressure, the residue re-dissolved in a little methanol and the solution is passed through a short column of anion exchange resin (Amberlite IRC 400, chloride form) using methanol as eluent. After removal of solvent, the product is dried at high vacuum to give a violet solid. 1H-NMR : 6H (300MHZ, CD30D) : 0. 89 (t, 3H, 3J= 7.5 Hz), 1.18-1. 34 (m, LOH), 1.41 (bs, 2H), 1.73 (quint, 2H, 3J= 7.5 Hz), 2.30-2. 44 (m, 6H), 3,31 (bs, 27H), 3.65-3. 73 (m, 6H), 3.93 (t, 2H, 3J= 7.5 Hz), 4.25-4. 42 (m, 6H), 7.08 (d, 2H, 3J= 7.5 Hz), 7. 30 (d, 6H, 3J= 7.5 Hz), 7.93 (d, 2H, 3J= 7.5 Hz), 8.05 (d, 6H, 3J= 7.5 Hz), 8.94 (bs, 8H)

3779-42-8, The synthetic route of 3779-42-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DESTINY PHARMA LIMITED; SOLVIAS AG; WO2004/56828; (2004); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.

Example 4: Preparation of RuCI [ (1 S, 2S)-p-dansylNCH (C6H5) CH (C6H5) NH2] (rl6-p-cymene) a) Preparation of (S, S)-5-dimethylamino-naphthalene-1-sulfonic acid (2-amino-1, 2-diphenyl- ethyl)-amide : To a solution of (S, S)-diphenylethylenediamine (250 mg, 1.2 mmol) and triethylamine (0.5 ml) in THF is added dropwise a solution of dansyl chloride (318 mg, 1.2 mmol) in THF (2 mi) at 0C. After stirring 16 h at RT the solvent is removed in vacuum and the residue is resolved in methylenchloride (20 ml). The organic solution is washed with NaHCO3 solution (5 ml), dried over Na2SO4 and after filtration the solvent is removed. Flash chromatographie afford (S, S)-5-dimethylamino-naphthalene-1-sulfonic acid (2-amino-1,2- diphenyl-ethyl)-amide as yellow oil which crystallizes by drying in vacuum. M: 445. 59. in- NMR (400 MHz, CDCl3) : 8.36 (t, J = 7.5 Hz, 2 H), 8.17 (dd, J = 7.2, 1.2 Hz, 1 H), 7.47 (dd, J = 8.8 Hz, 1 H), 7. 34 (dd, J = 8.5 Hz, 1 H), 7.24-7. 16 (m, 4 H), 7.11 (d, J = 7.5 Hz, 1 H), 6.99- 6.74 (m, 6 H), 4.61 (d, J = 8.5 Hz, 1 H), 4.20 (d, J = 8.5 Hz, 1 H), 2.80 (s, 6 H)

29841-69-8, The synthetic route of 29841-69-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/92294; (2005); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

5mmol of Phen-NH2, 5.5mmol of indoline-2,3-dione and 0.1mmol of 4-methylbenzenesulfonic acid were added into 25mL of ethanol and heated to reflux overnight. After cooling, the solution was poured into 300mL of cold water. The crude product was collected and recrystalized in ethanol to yield IPP as gray powder. 1H NMR (300Hz, CDCl3, 25¡ãC): delta 10.13 (d, 1H, J=8.5Hz), 9.24 (d,1H, J=2.5Hz), 9.17 (d, 1H, J=2.0Hz), 9.09 (d, 1H, J=5.5Hz), 8.55 (d, 1H, J=5.5Hz), 7.60?7.64 (m, 2H), 7.55 (d, 1H, J=8.5Hz), 7.34 (m, 2H). Anal. Calcd for C20H11N5: C, 74.76; H, 3.45; N, 21.79. Found: C, 74.67, H, 3.60; N, 21.68., 168646-54-6

As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Article; Li, Xiaogang; Zhang, Dong; Li, Jing; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 127; (2014); p. 1 – 9;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

29176-55-4, 2,9-Dichloro-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried Schlenk flask was evacuated and back-filled with argon three times. (Hetero)aryl (di)halide (1 equiv), base (1.5 equiv per halogen) and a solution of SPO (1.2 equiv per halogen) in anhydrous solvent (5 mL/mmol per halogen) were added to the flask. The solution was bubbled with argon for 10 min and Pd(OAc)2 (1 mol% per halogen) and ferrocene-based bidentate phosphine ligand (2 mol% per halogen) were added to the flask simultaneously [2.5 mol% Pd(OAc)2 per halogen and 5 mol% dppf per halogen for compounds 2j, 2l, 2r, 2t, 2w]. The resulting mixture was heated at the indicated temperature for the given time. Workup procedures are described below for two different conditions. Final purification of crude products was achieved by column chromatography on silica gel (40-60 mum) using CH2Cl2-MeOH as eluent. Reaction scale and yields are shown in Table 1 (2a-w), Scheme 1 (3a-h) and Scheme 2 (4a-g). Notice that all compounds with two phosphine oxide groups are beige-to-brown solids or slowly solidifying viscous brown oils. Conditions I: ligand: dppf, solvent: DMF, base: Cs2CO3 (2d-n, 2q, 2r, 2t-w, 4a-g) or K2CO3 (3a-h), temperature: 120 C, time: 7 h (20 h for 2j, 2l, 2r, 2w). Workup: after cooling, the reaction mixture was poured into a fourfold excess of brine. The mixture was extracted three times with CH2Cl2 (40 mL/mmol each). The combined organic layers were washed with brine to remove traces of DMF, dried over Na2SO4 and then evaporated to dryness. Conditions II: ligand: dippf, solvent: toluene, base: t-BuOK, temperature: 110 C, time: 7 h. Workup: after cooling, the reaction mixture was evaporated to dryness. Then, the mixture was diluted with CH2Cl2 (40 mL/mmol) and washed with water and brine (40 mL/mmol). The organic layer was dried over Na2SO4 and the CH2Cl2 was removed under reduced pressure.

29176-55-4, As the paragraph descriping shows that 29176-55-4 is playing an increasingly important role.

Reference£º
Article; Zakirova, Gladis G.; Mladentsev, Dmitrii Yu.; Borisova, Nataliya E.; Synthesis; vol. 51; 11; (2019); p. 2379 – 2386;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.

trans-RuH(eta1-BH4)[(s)-xylbinap][(S,S)-dpen] was synthesized. First, trans-RuCl2[(S)-xylbinap][(S,S)-dpen] was synthesized. That is, [RuCl2(benzene)]2 (62.5 mg; 0.125 mmol) (made by Aldrich Inc.) and (R)-XylBINAP (183.5 mg; 0.25 mmol) were weighed and placed in a 75 mL Schlenk reaction tube equipped with a stirrer coated with polytetrafluoroethylene, and after depressurizing the interior of the vessel to eliminate air, argon was introduced. After then adding DMF (3 mL) with a syringe, heating in an oil bath set to 100 C. was performed for 10 minutes under an argon atmosphere. After cooling the reaction solution to room temperature, DMF was distilled off under reduced pressure(1 mmHg). (S, S)-DPEN (53.0 mg; 0.25 mmol) (made by Kankyo Kagaku Center Co., Ltd.) and methylene chloride (3 mL) were then added under an argon gas flow to the reddish-brown RuCl2[(S)-xylbinap] (dmf)n solution thus obtained and stirring at 25 C. was performed for 1 hour. A green-colored crude product obtained by distilling off the methylene chloride under reduced pressure (1 mmHg) was dissolved in a 1:1 volume ratio methylene chloride/diethyl ether mixed solvent (2 mL) and this was passed through a column packed with silica gel (5 g) using a 1:1 volume ratio diethyl ether-hexane solution as an eluate to remove impurities. A yellow solution obtained as a precursor was then concentrated until a complex precipitated and solids were separated by filtration and dried under reduced pressure (1 mmHg) to obtain trans-RuCl2[(S)-xylbinap][(S,S)-dpen] (214.8 mg; 0.192 mmol; yield: 77%) as a yellow powder. [XylBINAP] and [xylbinap] are abbreviations for 2,2′-bis(di-3,5-xylylphosphino)-1,1′-binaphthyl. [00032] The abovementioned trans-RuCl2[(S)-xylbinap] [(S,S)-dpen] (89.5 mg; 0.08 mmol) and sodium borohydride (75.6 mg; 2.0 mmol) (made by Nacalai Tesque, Inc.) were then weighed and placed in a 20 mL Schlenk reaction tube equipped with a stirrer coated with polytetrafluoroethylene, and after depressurizing the interior of the vessel to eliminate air, argon was introduced. After then adding a 1:1 volume ratio mixed solvent of benzene/ethanol (6 mL) with a syringe, heating in an oil bath set to 65 C. was performed for 5 minutes under an argon atmosphere. The reaction solution was thereafter stirred for 30 minutes at room temperature. After then drying and solidifying the crude product by distilling off the solvent under reduced pressure (1 mmHg), hexane (5 mL) was added under an argon gas flow to dissolve as much of a yellow product as possible and then the excess sodium borohydride was eliminated by filtration by celite (0.5 g). A yellow filtrate thus obtained was concentrated to approximately 1 ml by depressurization (1 mm Hg) and yellow solids thus precipitated were separated by filtration through a glass filter and dried under reduced pressure (1 mmHg) to obtain trans-RuH(eta1-BH4)[(S)-xylbinap][(S,S)-dpen] (38.3 mg; yield: 45%; see formula (4) below) as a yellow powder. Decomposition temperature: 220 C.; 1HNMR(400 MHz, C6D6) delta-13.67(t, 1, J=23.2 Hz, RuH), -0.48(brs, 4, BH4), 1.59(brs, 12, 4 CH3), 1.78(s, 6, 2CH3), 2.00(s, 6, 2CH3), 2.28-2.35(m, 2, 2NHH), 3.62-3.67(m, 1, CHNH2), 3.76-3.81(m, 2,2CHNH2), 4.09 (dd, 1, J=9.6 and 18.2 Hz, CHNH2), 5.77-8.38(m, 34, aromatics); 31PNMR(161.7 MHz, C6D6) delta73.1(d, J=41.4 Hz), 76.8(d, J=41.4 Hz); IR(toluene)2319(s), 1850(s), 1125(s)cm-1; ESI-MS m/z1063.33([M-H]+), theoretical value (C66H68BN2P2Ru): 1063.40.

29841-69-8, 29841-69-8 (1S,2S)-(-)-1,2-Diphenylethylenediamine 6931238, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Nagoya Industrial Science Research Institute; US6720439; (2004); B1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4479-74-7, 2,2-Bipyridine-6,6-dicarboxylic Acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of Tb(NO3)3¡¤6H2O (0.045 g, 0.10 mmol), H2bpdc (0.024 g, 0.10 mmol) in distilled water (10 mL) that adjusted the pH value to 2.5 with 0.5 mol L-1 NaOH aqueous solution. It was then sealed in a 25 mL Teflon reactor and heated at 160 C for 72 h, and then cooled to ambient temperature at a rate of ca.2 C h-1 to give colorless block crystals of 7, yield: 57% based on H2bpdc.

4479-74-7, The synthetic route of 4479-74-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ren, Ya-Lan; Wang, Fei; Hu, Huai-Ming; Chang, Zhuguo; Yang, Meng-Lin; Xue, Ganglin; Inorganica Chimica Acta; vol. 434; (2015); p. 104 – 112;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI