Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3779-42-8,3-Bromo-N,N,N-trimethylpropan-1-aminium bromide,as a common compound, the synthetic route is as follows.

COMPOUND 28; 5,15-bis-[3-(3-Trimethylammmonio-propylox)0-ph.enyl]-10-undecyl- porphyrin dichloride; To a solution of Compound 27 (50 mg, 0.08 mmol) in DMF (20 mL) under an argon atmosphere K2CO3 (100 mg, 0.72 mmol) and (3- bromopiOpyl)-trimethylammonium bromide (300 mg, 1.2 mmol) are added and the mixture is stirred at 500C for 18 h. After removal of solvent under high vacuum the residue obtained is dissolved in methanol (5 mL) and filtered through a pad of silica gel (depth 2 cm) supported on a steel frit (diameter 3.5 cm). After washing the pad with methanol (500 mL) it is eluted with acetic acid:methanol:water (3:2:1, v:v). After drying of appropriate combined fractions under high vacuum the residue is dissolved in methanol and purified by column chromatography on Sephadex LH-20 eluting with n-butanol: acetic acid: water (5: 1:4, by vol., upper phase). After evaporation of solvent the residue obtained from the first fraction eluted is dissolved in methanol and passed through a short column of anion exchange resin (Amberlite IRA 400. chloride form) to give, after evaporation of solvent, the pure product.1H-NMR: deltaH (300Mz, CD3OD): 0.85 (t, 3Z 7.5 Hz, 3 H), 1.20-1.40 (m, 12 H), 1.50 (m, 2 H), 1.80 (m, 2 H), 2.40 (bs, 4 H), 2.55 (m, 2 H), 3.20 (bs, 18 H), 3.65 (bs, 4 H), 4.35 (bs, 4 H), 5.10 (m, 2 H), 7.50-7.55, 7.70-7.85 (2 x m, 8 H), 8.95-9.00, 9.25-9.24, 9.50-9.70 (3 x bs, 8 H), 10.15 (bs5 IH).

3779-42-8, 3779-42-8 3-Bromo-N,N,N-trimethylpropan-1-aminium bromide 151145, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; DESTINY PHARMA LIMITED; WO2006/765; (2006); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

99970-84-0, [2,2′-Bipyridine]-4,4′-dicarbaldehyde is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a flame-dried round bottle flask with a magnetic stirring bar were addedbipyridine aldehyde (0.001 mmol) 2 and (DABCO) as catalyst (10 mol%)) in methanol(4mL), followed by the addition of activated alkenes 4. The resulting mixture was stirred atroom temperature for 12 hours, after completion of the reaction (Monitored by TLC),solvents were removed in vacuo and the residue was purified on neutral alumina using 70%ethyl acetate in petroleum ether to afford the corresponding novel Morita-Baylis-Hillmanadduct of bipyridine 5 in very good yield., 99970-84-0

The synthetic route of 99970-84-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gouthaman, Siddan; Periyaraja, Somasundharam; Shanmugam, Ponnusamy; Tetrahedron Letters; vol. 56; 43; (2015); p. 5920 – 5923;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2304-30-5

EXAMPLE 2 2-Benzylthio-5-chlorophenylisonitrile A reaction flask was charged under a nitrogen atmosphere with 6 g (0.03 mole) of 2-mercapto-5-chloroaniline hydrochloride, 4 g (0.03 mole) of benzyl chloride, 5 ml of 50% aqueous sodium hydroxide, and 250 mg of tetra-n-butylphosphonium chloride. The mixture was heated to reflux for two hours, and 3 ml each of benzene and water were added. The organic phase was then washed with a 10% caustic solution and evaporated to yield 8.1 g of a black oil, confirmed by mass spectroscopy to be 2-benzylthio-5-chloroaniline. A reaction flask was then charged with 6 g (0.02 mole) of this product, 5 ml of chloroform, 10 ml of methylene chloride, 10 ml of 50% aqueous sodium hydroxide solution, and 100 mg of benzyltriethylammonium chloride. The procedure of Example 1 was then followed, producing 6 g of a black oil, which was passed through an alumina chromatography column with hexane, followed by a hexane-benzene mixture.

2304-30-5 Tetrabutylphosphonium chloride 75311, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Stauffer Chemical Company; US4380468; (1983); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

787-70-2, [1,1′-Biphenyl]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,787-70-2

A mixture of H2BPDC (0.097g, 0.4mmol), Melamine (0.050g, 0.4mmol), DMF (4mL), ethanol (4mL) and H2O (4mL) was sealed into a 20mL Teflon-lined stainless-steel reactor and heated at 105C for 3days under autogenous pressure, and then followed by slowly cooling to room temperature at a rate of 1.7C¡¤h-1. The obtained flavescens cuboid-like crystals of 1 were collected (yield: 80 % based on Melamine) after washing with ethanol and drying in air. Elemental analysis: calcd. (%) for C20H30N12O8: C: 42.40, H: 5.34, N: 29.67, O: 22.59; found: C: 42.11, H: 5.81, N: 29.32, O: 22.76. FT-IR (KBr, 4000-500cm-1)=3380(w), 2667(w), 1890(m), 1686(vs), 1632(s), 1509(vs), 1390(m), 1205(m), 1009(w), 1004(m), 850(s), 760(s), 700(s) cm-1.

The synthetic route of 787-70-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Ruichao; Liu, Jie; Yan, Xiangzhen; Yuan, Chunxue; Polyhedron; vol. 157; (2019); p. 1 – 5;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-91-5,2,2′-Biquinoline,as a common compound, the synthetic route is as follows.

EXAMPLE 285 2,3-Dihydro-2-[1-[3-phenyl-3-(4-propylphenyl)propyl]-4-piperidinyl]-1H-isoindol-1-one, monohydrochloride STR169 To a suspension of magnesium turnings (1.0 g, 41.2 mmol) in THF (8.2 mL) was added a solution of 1-bromo-4-propylbenzene (Aldrich) (1.64 g, 8.20 mmol) in THF (8.2 mL). The reaction was refluxed for 1.5 h, then cooled to RT. The Grignard solution was cannulated then titrated against 1.0M isopropanol in toluene using 2,2-biquinoline as an indicator to give title compound (0.35M, 70%) as a black solution. STR170 To a solution of Example 284 compound (500 mg, 1.37 mmol) in THF (8 mL) was added dropwise at 0 C. a solution of Part A compound (4.3 mL, 1.51 mmol). The reaction was stirred at 0 C. for 3 h then warmed to RT for 3 h. The reaction was quenched with saturated ammonium chloride solution (3 mL). Ethyl ether (200 mL) was added and the organic was washed with water (2*50 mL), brine (2*50 mL) and dried over MgSO4. Evaporation gave title compound (400 mg, 63%) as a crude oil., 119-91-5

The synthetic route of 119-91-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bristol-Myers Squibb Company; US5739135; (1998); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

In a 100mL single-necked flask was added 0. 33g4,4′-dinitrobenzil (l.Ommol) and 0. 21g 5,6-diamine-1,10-phenanthroline (1.0 mmol)Add 30mL glacial acetic acid,Stirring, reaction under nitrogen 2h. After the reaction,Rotate the solvent, spin-dry after adding the appropriate amount of dichloromethane stirring lmin.Filtration, rotary evaporation of the solvent. The resulting solid is anhydrousEthanol recrystallized, suction filtered and dried in vacuo to give pale yellow crystals 0. 352g, a yield of 78.6percent.

168646-54-6, As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Patent; Jiangnan University; Zheng Changge; Xie Chen; Li Mingyue; (7 pag.)CN105884835; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.114527-28-5,4-(4′-Methyl-[2,2′-bipyridin]-4-yl)butanoic acid,as a common compound, the synthetic route is as follows.

General procedure: Prepared from 15 mg scale reactions with the Ru(dppz)(bpy?-CO2CH3)2Cl2 complex described above. The bis-ligated starting material was massed dry on paper and transferred to a 10 mL schlenck bulb flask along with one equivalent of bpy?-CO2CH3 (Complex 7) or bpy?-CO2H (Complex 8), both transferred as oils. Reactions involved refluxing approximately 4 mL 1:1 ethanol:water for 36-48 h with vigorous stilling under the protection of nitrogen and in low light conditions. The work up for these reactions followed general procedures. (73% yield for Complex 7; 85% yield for Complex 8)

114527-28-5, The synthetic route of 114527-28-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NORTHWESTERN UNIVERSITY; Mirkin, Chad A.; Shade, Chad M.; Kennedy, Robert D.; Rouge, Jessica Lynn; Seo, Soyoung E.; Wang, Mary X.; (17 pag.)US9969759; (2018); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The phase-transfer catalysts (C1-C11) were synthesized according to the proceduresbelow. To a solution of cinchonidine (1.00 g, 3.4 mmol) in THF (50 mL) was addedthe aryl benzyl bromides (3.4 mmol). The mixture was heated for 6-8 h at reflux.After cooling to room temperature, the mixture was poured into MTBE (150 mL)under stirring. The precipitated solid was filtrated and recrystallized fromCH3OH/MTBE to afford C1-C11

485-71-2, 485-71-2 Cinchonidine 101744, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Li, Ruipeng; Liu, Zhenren; Chen, Liang; Pan, Jing; Zhou, Weicheng; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1421 – 1427;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4479-74-7,4479-74-7, 2,2-Bipyridine-6,6-dicarboxylic Acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of Ca(NO3)2¡¤4H2O (60.0mg, 0.25mmol), H2BD (10.0mg, 0.04mmol) and 2.0mL DMF was sealed in a 10mL pressure-resistant glass tube, which was then heated to 100C within 100min and kept at 100C for 1440min followed by slowly cooled to 30C within 200min. Colourless crystals were obtained and washed with DMF and then dried in the air (yield: 71%. Based on Calcium.). Elemental Anal. Calc. for 1 C18H22CaN4O6: C, 44.12; H, 4.90; N, 13.72. Found: C, 44.51; H, 4.73; N, 12.23%. IR (KBr): 3460 (s), 2931 (w), 1660 (s), 1611 (s), 1548 (s), 1386 (s), 1255 (w), 1099 (m), 851 (w) 788 (s) 688 (s) 576 (w)cm-1.

As the paragraph descriping shows that 4479-74-7 is playing an increasingly important role.

Reference£º
Article; Wang, Yutong; Fan, Weidong; Wang, Xia; Liu, Di; Huang, Zhaodi; Dai, Fangna; Gao, Jing; Polyhedron; vol. 155; (2018); p. 261 – 267;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

57709-61-2, 1,10-Phenanthroline-2,9-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under anhydrous conditions, 4-dimethylaminopyridine (DMAP,340 mg, 2.8 mmol, 2.5 equiv), N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (EDC¡¤HCl, 640 mg, 3.4 mmol,3.0 equiv), and 3-aminoquinoline (450 mg, 3.1 mmol, 2.8 equiv)were added as solids to a suspension of compound 3 (3.0¡¤102mg, 1.1 mmol, 1.0 equiv) in DMF (23 mL). The solution wasplaced under argon and stirred at room temperature (48 h). Theresulting yellow suspension was filtered under vacuum, and theisolated precipitate washed with saturated aqueous sodiumbicarbonate (30 mL), CH2Cl2 (20 mL), and diethyl ether (20 mL)to afford pure compound 4 as a pale yellow solid (490 mg, 85percent).1H NMR (300 MHz, DMSO-d6): delta = 7.68 (t, 3J = 7 Hz, 2 H), 7.75 (t,3J = 7 Hz, 2 H), 8.09?8.13 (m, 4 H), 8.33 (s, 2 H), 8.69 (d, 3J = 8 Hz,2 H), 8.91 (d, 3J = 8 Hz, 2 H), 9.17 (d, 4J = 2 Hz, 2 H), 9.68 (d, 4J = 2Hz, 2 H), 11.88 (s, 2 H); mp >280 ¡ãC (lit. >260 ¡ãC).7, 57709-61-2

As the paragraph descriping shows that 57709-61-2 is playing an increasingly important role.

Reference£º
Article; Miron, Caitlin E.; Petitjean, Anne; Synlett; vol. 29; 10; (2018); p. 1362 – 1366;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI