Tag: M.W:200-300

5350-41-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5350-41-4,N,N,N-Trimethyl-1-phenylmethanaminium bromide,as a common compound, the synthetic route is as follows.

General procedure: To a 50mL Schlenk tube containing benzylic ammonium iodide (0.5mmol), arylboronic acid (2.0mmol), K3PO4 (2.25mmol), castalyst (5molpercent) and PPh3 (20molpercent) were added and the tube was purged with N2 for 3 times. Then 1,4-dioxane (2.0mL), subsequently, was introduced to the tube. The resulted mixture was allowed to stir for 24h at 80¡ãC under atmosphere of N2. After the completion of the reaction, the resulting mixture was filtered through a Celite pad and concentrated under the vacuum and directly purified by flash chromatography to give the desired product.

As the paragraph descriping shows that 5350-41-4 is playing an increasingly important role.

Reference£º
Article; Liu, Xi-Yu; Zhu, Hai-Bo; Shen, Ya-Jing; Jiang, Jian; Tu, Tao; Chinese Chemical Letters; vol. 28; 2; (2017); p. 350 – 353;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of 6-(2,2′:6′,2″-Terpyridine-4′-yloxy)-hexylamine To a suspension of KOH (2.70 g, 48 mmol) in anhydrous DMSO (50 mL) was added 6-Amino-1-hexanol (1.17 g, 10 mmol). The suspension was warmed up to 60 C. and stirred for additional 30 min, followed by addition of 4′-chloro-2,2′:6′,2″-terpyridine (2.68 g, 10 mmol). The reaction mixture was kept stirring for 2 d at the same temperature. The solution was then allowed to cool down to R.T., poured into deionized water (500 mL), stirred and allowed to precipitate overnight. The product was filtered off and dried up under high vacuum to give 2 as a pale yellow solid (2.90 g, 83.3%). 1H NMR (400 MHz, CDCl3): delta 1.47-1.86 (m, 8H), 2.74 (t, J=6.5 Hz, 2H, NCH2), 4.22 (t, J=6.5 Hz, 2H, OCH2), 7.34 (dd, J=2.0 Hz, 5.0 Hz, 2H, H5,5″(terpy)), 7.84 (td, J=2.0 Hz, 7.5 Hz, 2H, H4,4″(terpy)), 8.03 (s, 2H, H3′,5′(terpy), 8.67 (d, J=8.5 Hz, 2H, H3,3″terpy)), 8.70 (d, J=5.0 Hz, 2H, H6,6″(terpy)). GC-MS: m/z 348 (100%) (M+).

128143-89-5, 128143-89-5 4′-Chloro-2,2′:6′,2”-terpyridine 667748, acatalyst-ligand compound, is more and more widely used in various fields.

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Patent; Massachusetts Institute of Technology; CHEN, Pangkuan; HOLTEN-ANDERSEN, Niels; (58 pag.)US2016/152638; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

6813-38-3, [2,2′-Bipyridine]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6813-38-3, Take the product I obtained 2g and 10mL 98% H2SO4, 100mL CH3OH into the flask with a stirrer, reflux at 105 C overnight, the end of the reaction to a large amount of water appears white flocculent precipitate, slowly adding NaOH solution adjusted to pH 9.0 , With CH2C12 extract to retain the organic phase, anhydrous Na2S04 dry, evaporated to dry the solvent to obtain white crystals, the yield of 88%.

As the paragraph descriping shows that 6813-38-3 is playing an increasingly important role.

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Patent; Nanjing University of Posts and Telecommunications; Zhao, Qiang; Huang, Wei; Huang, Tianci; Liu, Shujuan; Xu, Wenjuan; Zhu, Yana; (10 pag.)CN106188151; (2016); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.168646-54-6,5,6-Diamino-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

1) Under a nitrogen atmosphere,4,4′-dimethyldiphenylamine (1.97 g, 10 mmol)CuI (28.5 mg, 0.15 mmol),1,10-phenanthroline (54 mg, 0.3 mmol)Potassium hydroxide (1.12 g, 15 mmol),2-iodo-dithiophene (3.16 g, 12 mmol),Water (7 mL) and xylene (20 mL)The reaction was carried out at 130 ¡ã C for 24 hours,The reaction mixture was poured into methylene chloride (100 mL), washed with water, and the organic phase was collected and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was passed through a silica gel column. The mobile phase was a 1: 3 by volume mixture of dichloromethane and petroleum ether to give intermediate P3;2)The intermediate P3 (3.35 g, 10 mmol) was dissolved in dry dichloromethane (50 mL)Anhydrous aluminum trichloride (1.6 g, 12 mmol) was added portionwise at 0 ¡ã C,After stirring for 20 minutes,A solution of oxalyl chloride (5 mmol) in dichloromethane (10 mL) was slowly added dropwise,Drop finished, rose to room temperature to continue stirring 6 hours, the reaction completed,A 10percent aqueous hydrochloric acid solution (10 mL) was added dropwise to the reaction solution,The organic phases were collected, washed with saturated sodium bicarbonate solution and water, dried over anhydrous sodium sulfate,The solvent was distilled off under reduced pressure,The residue was passed through a silica gel column and the mobile phase was a 1: 1 by volume mixture of dichloromethane and petroleum ether to give intermediate P4;3) 5,6-diamino-1, 10-phenanthroline A (2.10 g, 10 mmol)Intermediate P4 (10 mmol) and glacial acetic acid (40 mL) were refluxed at 120 & lt; 0 & gt; C for 24 hours,Down to room temperature,The solvent was distilled off under reduced pressure,The residue was extracted with chloroform,Washed with 10percent sodium bicarbonate solution and saturated brine, respectively,Dried over anhydrous sodium sulfate.The solvent was distilled off under reduced pressure, the residue was passed through a silica gel column,The mobile phase is a 1: 1 by volume mixture of methylene chloride and ethyl acetate,The organic photosensitive dye D2, the yield of 56percent

168646-54-6, As the paragraph descriping shows that 168646-54-6 is playing an increasingly important role.

Reference£º
Patent; China Academy of Sciences Huaxue Academe; Zhang, Lipeng; Fan, Xinheng; Chen, Qiang; Jiang, Kejian; Yang, Lianming; (14 pag.)CN104672237; (2017); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

2304-30-5, Tetrabutylphosphonium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The same procedure described above for the preparation of [nBu4P][PtBr3(C2H4)] was adopted, except for the use of PtCl2 (100.2 mg, 0.38 mmol) and nBu4PCl (102.4 mg, 0.38 mmol), with the addition of 10 mL of dry toluene. Yield: 148.4 mg, 66%. 1H NMR (CDCl3): delta 4.48 (s + d, JPt-H = 64.3 Hz, 4H, C2H4), 2.30 (m, 8H, br, PCH2), 1.60 (m, 4, br, CH2CH2), 1.05 (m, 3, br, CH3). 31P{1H} NMR: delta 33.14. 195Pt NMR: delta -2743(quint 2JPt-H = 64 Hz). Anal. % Calcd. for C18H40Cl3PPt (M = 588.930): C, 36.71; H, 6.85. Found: 37.2; H, 6.9., 2304-30-5

As the paragraph descriping shows that 2304-30-5 is playing an increasingly important role.

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Conference Paper; Bethegnies, Aurelien; Poli, Rinaldo; Journal of Organometallic Chemistry; vol. 730; (2013); p. 165 – 167;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29841-69-8,(1S,2S)-(-)-1,2-Diphenylethylenediamine,as a common compound, the synthetic route is as follows.

A solution of sulfonyl chloride B (10 mmol) in dichloromethane (25 mL) was slowlyadded to a stirred solution of diamine A (10 mmol), NEt3 (11 mmol) in dichloromethane(25 mL). The resulting mixture was stirred for another 3 hr, washed twice with water (25mL) and dried over Na2SO4. The solvent was removed in vacuo to give a white solid C. Toa solution of D in CH2Cl2 (40 mL) was added NEt3 (11 mmol), isobutyl carbonochloridate(11 mmol) at 0 oC under stirring. After 10 min, C was added. The reaction was allowed towarm to room temperature for another 3 hr. The mixture was washed with 1 M KHSO4solution, saturated NaHCO3 solution, and brine, dried over anhydrous Na2SO4 andconcentrated to get a white solid E. Then, TFA (10 mL) was added to the CH2Cl2 (10 mL)solution of E, and stirred until the reaction finished (1 hr). The pH value of the mixture wasbrought into the range of 10-12 by the addition of 2 N NaOH solution. The aqueousphase was extracted with CH2Cl2 (3 ¡Á 30 mL). The combined organic phase was washedwith brine, dried over anhydrous Na2SO4, and concentrated and purified through flashchromatograph as a white solid F (70% yield).

29841-69-8, The synthetic route of 29841-69-8 has been constantly updated, and we look forward to future research findings.

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Article; Tang, Yu; Xu, Jian; Yang, Jian; Lin, Lili; Feng, Xiaoming; Liu, Xiaohua; Chem; vol. 4; 7; (2018); p. 1658 – 1672;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

3779-42-8, 3-Bromo-N,N,N-trimethylpropan-1-aminium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a vigorously-stirred suspension of Compound 5 (80 mg, 0.14 mmol) and K2CO3 (230 mg, 1.7 mmol) in DMF (30 mL) is added (1- bromopropyl) -trimethylammonium bromide (0.3 g, 16.6 mmol) at 50 C. The mixture is stirred at this temperature for 18 h. After removal of the DMF under reduced pressure, the residue obtained is dissolved in methanol (5 mL) and filtered through a pad of silica gel (depth 2 cm) supported on a steel frit (diameter 3.5 cm). After washing the pad with methanol (ca. 1L) the crude product is eluted with acetic acid: methanol: water (3: 2: 1, by vol. ). Appropriate fractions are collected and, after evaporation of the solvent under reduced pressure, the residue obtained is purified by chromatography on a column (2.5 x 40 cm) of Sephadex LH-20 eluting with n-butanol: water: acetic acid (5: 4: 1, by vol., upper phase). After removal of the solvent from appropriate fractions under reduced pressure, the residue obtained is dissolved in methanol (5 mL) and the solution is passed through a short column (3.5 x 20 cm) of anion exchange resin (Amberlite IRA 400, chloride form). After collection of the eluate, solvent is removed under reduced pressure and the residue obtained is dried under high vacuum to yield the dichloride salt as violet crystals. 1H-NMR : 6H (300MZ, CD30D) : 0.75 (T, 3J7. 5 Hz, 3 H), 1.05-1. 20 (m, 14 H), 1.45- 1.50 (m, 2 H), 2.05-2. 15 (m, 4 H), 2.15-2. 20 (m, 2 H), 2.95 (s, 18 H), 3.35-3. 45 (m, 4 H), 3.95 (T, 3J7. 5 Hz, 4 H), 4.55 (t, 3J7. 5 Hz, 2 H), 6. 85 (m, 1 H), 7.35 (m, 2 H), 8.85-8. 90,9. 15-9.20, (3 X M, 8 H), 10.10 (s, 2 H).

3779-42-8, The synthetic route of 3779-42-8 has been constantly updated, and we look forward to future research findings.

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Patent; DESTINY PHARMA LIMITED; SOLVIAS AG; WO2004/56828; (2004); A2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14162-95-9,4-Bromo-2,2′-bipyridine,as a common compound, the synthetic route is as follows.

In a flame dried 50-mL 3-neck flask fitted with a condenser, a mixture of anthraceneboronic acid 35-7 (522 mg, 0.985 mmol), 4-bromo-2,2?-bipyridine (154 mg, 0.657 mmol), and cesium carbonate (640 mg, 1.97 mmol) in EtOH (15 mL) and water (2 mL) was degassed by refluxing under argon stream for 75 minutes. Then Pd(OAc)2 (29.7 mg, 0.131 mmol) and PPh3 (138 mg, 0.526 mmol) were added in one portion. Refluxing under argon was continued until the reaction was complete in 90 minutes. The reaction mixture was then allowed to cool to room temperature and filtered; the solid residue was rinsed with DCM and MeOH. The filtrate was concentrated in vacuo, and the resulting residue was purified by reversed-phase flash chromatography (C18 190 SiO2, eluted with gradient of 0.09% 58 HCl in 23 MeOH). The pure product was isolated by basification of combined and concentrated fractions with solid 43 NaHCO3 (200 mg) followed by extraction with DCM twice. The combined DCM layers were then dried over MgSO4 and concentrated in vacuo to yield 192 product as a yellow solid (316 mg, 50%).

14162-95-9, 14162-95-9 4-Bromo-2,2′-bipyridine 12087122, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Profusa, Inc.; GAMSEY, Soya; BERNAT, Viachaslau; KUTYAVIN, Alex; CLARY, Jacob William; PRADHAN, Sulolit; (192 pag.)US2018/179233; (2018); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

6813-38-3, [2,2′-Bipyridine]-4,4′-dicarboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6813-38-3, A monocarboxylic acid, 4-carboxy-4?-ethyl-2,2?-bipyridine 9 was identified as methyl ester as follows. Isolated mixture of 2 and 9 (Table 4, entry 5) was dissolved in 40 mL methanol, and 1 mL conc. H 2 SO 4 was added. The solution was refluxed for 24h, and then the cooled mixture was neutralized by adding aqueous NaHCO 3 solution. After removal of methanol at reduced pressure, H 2 O was added to the residue, and insoluble dimethyl 2,2′-bipyridine-4,4′-dicarboxylate S7 was filtered off and washed well with H 2 O. The filtrate and washings were combined and extracted with CH 2 Cl 2 . The organic layer was separated, dried with anhydrous Na 2 SO 4 , and the solvent was removed out under a reduced pressure. The colorless oil obtained was identified as 4-ethyl-4?-methoxycarbonyl-2,2?-bipyridine 16by its spectral data. The colorless oil solidified on standing several days in freezer. 4-Ethyl-4?-methoxycarbonyl-2,2?-bipyridine 16: mp 38-40C 1 H NMR (400 MHz, CDCl 3 ,TMS) ppm: 1.32 (3H, t, J=7.6 Hz), 2.76 (2H, q, J=7.6 Hz), 7.20 (1H, dd, J=5.0 Hz, 1.8 Hz), 7.86 (1H, dd, J=5.0 Hz, 1.8 Hz) 8.28 (1H, t, J=0.9 Hz), 8.61 (1H, d, J=5.0 Hz), 8.63 (2H, s), 8.82 (1H, dd, J=5.0 Hz, 0.9 Hz) 8.93 (1H, t, J=0.9 Hz); 13 C NMR (100 MHz, CDCl 3 , TMS) ppm: 14.4, 28.4, 52.7, 120.6, 120.9, 122.7, 123.9, 138.5, 149.3, 149.8, 154.2, 155.2, 157.5, 165.8. IR (ATR, cm -1 ) 3437, 3056, 2967, 2947, 2925, 2882, 2847, 1932, 1721, 1592, 1552, 1460, 1439, 1291, 1230, 1106, 963, 843, 747, 684; MS (EI) m/z(%) 242 (79) [M] + , 241 (96), 184 (100); Anal. Calcd for C 14 H 14 N 2 O 2 : C, 69.41; H, 5.82; N, 11.56. Found: C, 69.31; H, 6.00; N, 11.16.

The synthetic route of 6813-38-3 has been constantly updated, and we look forward to future research findings.

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Article; Yamazaki, Shigekazu; Synthetic Communications; vol. 49; 17; (2019); p. 2210 – 2218;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4479-74-7, 2,2-Bipyridine-6,6-dicarboxylic Acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,2′-Bipyridine-6,6′-dicarboxylic acid (0.37 g,1.5 mmol) in mixture of thionyl chloride (10 ml) and DMF (0.3 ml) wasrefluxed for 2.5 h. Then thionyl chloride was removed, the solid residuewas dissolved in absolute THF (15 ml) and the resulting solution was addedportionwise to a solution of tetraethyl [iminodi(methylene)]bis(phosphonate)(1 g, 3.15 mmol) and Et3N (1 ml) in absolute THF (10 ml). The mixturewas stirred at room temperature for 16 h. Then water (5 ml) was addedand the organic layer was separated, washed with water and dried overanhydrous Na2SO4. The solvent was evaporated to leave dark oil. Thendiethyl ether (5 ml) was added to the oil and the mixture was ground untilprecipitate formation. The precipitate was filtered off, washed with colddiethyl ether and dried in air to afford product 3 as white powder. Yield1 g (79%), mp 116-118C. 1H NMR (600 MHz, CDCl3) delta: 1.19 (t, 12H,CH2Me, 3J 7.0 Hz), 1.36 (t, 12H, CH2Me, 3J 7.0 Hz), 3.94-4.01 (m, 8H,CH2Me), 4.20-4.27 (m, 8H, CH2Me), 4.39 (d, 4H, 2CH2P, 2J 11.1 Hz),4.76 (d, 4H, 2CH2P, 2J 11.2 Hz), 7.85 (d, 2H, 3,3′-CH, 3J 7.5 Hz), 7.97(t, 2H, 4,4′-CH, 3J 7.7 Hz), 8.50 (d, 2H, 5,5′-CH, 3J 7.2 Hz). 13C NMR(100 MHz, CDCl3) delta: 16.2 (d, J 5.1 Hz), 16.3 (d, J 5.0 Hz), 41.3 (d,J 155.9 Hz), 44.5 (d, J 154.7 Hz), 62.2 (d, J 6.0 Hz), 62.6 (d, J 5.7 Hz),122.1, 125.4, 138.2, 152.5, 153.1, 167.5. 31P NMR (162 MHz, CDCl3) delta:2 1.64, 21.65. MS (MALDI-TOF), m/z: 881 [M+K]+. Found (%): C, 45.72;H, 6.51; N, 14.78. Calc. for C32H54N4O14P4 (%): C, 45.61; H, 6.46;N, 14.70., 4479-74-7

The synthetic route of 4479-74-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Farat, Oleg K.; Kharcheva, Anastasia V.; Ioutsi, Vitaliy A.; Borisova, Natalia E.; Reshetova, Marina D.; Patsaeva, Svetlana V.; Mendeleev Communications; vol. 29; 3; (2019); p. 282 – 284;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI