Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4568-71-2,3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Step A Preparation of 1-(3,4-dimethoxyphenyl)-4-(2-naphthyl)butan-1,4-dione Sodium acetate (2.38 g), 3-benzyl-4-methyl-5(2-hydroxyethyl)thiazolium chloride (3.78 g), 2-naphthaldehyde (10.92 g), 3,4-dimethoxybenzaldehyde (17.43 g), vinylsulfone (7.00 ml) and dimethylformamide (dry DMF, 35 ml) were stirred at room temperature for about 13 days. The reaction mixture was partitioned between chloroform and water and the layers separated. The pooled organic layers were washed with water, dried over anhydrous potassium carbonate and evaporated in vacuo to give about 24.9 g of an oil. The oil was chromatographed to give 1.8 g of crude product which was crystallized from methanol to give 623.2 mg of pure 1-(3,4-dimethoxyphenyl)-4-(2-naphthyl)butan-1,4-dione, m.p. 133¡ã C.

4568-71-2, As the paragraph descriping shows that 4568-71-2 is playing an increasingly important role.

Reference£º
Patent; Merck & Co., Inc.; US4539332; (1985); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103946-54-9,4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid,as a common compound, the synthetic route is as follows.

103946-54-9, Weigh the NH2-C4 dichloro bridge 1mmolAnd 2.2 mmol of 4-methyl 4′-carboxy-2,2′-bipyridine was added to the reaction flask, vacuumed, and protected with nitrogen.Reacted at 40 C for 10 h,After adding KPF630mmol reaction for 2h,Spin dry, extract with dichloromethane (3 ¡Á 150mL), take the organic phase, spin dry into silica gel powder column, separate and purify,The yield was 59%.

103946-54-9 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid 11127621, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Nanjing University of Posts and Telecommunications; Zhang Yin; Wei Huanjie; Zhang Taiwei; Zhao Qiang; Liu Shujuan; Huang Wei; (11 pag.)CN107880076; (2018); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.134030-21-0,N1,N2-Dimesitylethane-1,2-diamine,as a common compound, the synthetic route is as follows.

Preparation of 1,3-dimesityl-4,5-dihydro-imidazolium tetrafluoroborate A round bottom flask was charged with 1,2-dimesityl ethylene diamine (3.8 g, 12.8 mmol), triethyl orthoformate (15 mL) and ammonium tetrafluoroborate (1.35 g, 12.8 mmol). The reaction mixture was stirred at 120 C. for 4 hours at which time TLC indicated complete conversion. Volatiles were removed in vacuo and the product was used as prepared or it could be purified further by recrystallization from ethanol/hexanes.

134030-21-0, As the paragraph descriping shows that 134030-21-0 is playing an increasingly important role.

Reference£º
Patent; CALIFORNIA INSTITUTE OF TECHNOLOGY; GRUBBS, Robert H.; SCHOLL, Matthias; (16 pag.)US2016/237101; (2016); A9;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2304-30-5,Tetrabutylphosphonium chloride,as a common compound, the synthetic route is as follows.

A stirred solution of sodium 2,2-dimethyl-N,N-dichlorotaurine (35 g, 143 mmol) in 175 mL of water was treated with a solution of tetrabutylphosphonium chloride (38 g, 129 mmol) in 175 mL of water. The resulting suspension was stirred 10 min then 400 mL of ethyl acetate was added and the mixture was stirred vigorously. After separation of the layers, the aqueous layer was extracted with 2¡Á200 mL of ethyl acetate. The combined organic layers were dried over sodium sulfate and filtered. The sodium sulfate pad was washed with 2¡Á100 mL of ethyl acetate. The filtrate was concentrated to dryness and placed under high vacuum overnight (0.4 torr)to constant weight which provided 2,2-dimethyl-N,N-dichlorotaurine tetrabutylphosphonium (59.9 g, 96.6%) as a white solid, mp 118-120 C. 1H NMR (CDCL3) 3.34 (s, 2H); 2.33 (q, 8H); 1.65 (s, 6H); 1.54 (m, 16H); 0.99 (t, 12H)., 2304-30-5

The synthetic route of 2304-30-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ALCON RESEARCH, LTD.; US2009/197838; (2009); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485-71-2,Cinchonidine,as a common compound, the synthetic route is as follows.,485-71-2

General procedure: A mixture of (-)-cinchonidine (1.0 mmol) and benzyl bromide 3 (1.0 mmol) having sulfonamidegroup was stirred in DMF (4 mL) at 25 C for 20 h. After the reaction was completed, the reaction mixture was added dropwise to ether (50mL) with stirring. The solid precipitated was filtered,washed with ether (20 mL) and hexane (20 mL) to afford cinchonidinium salt 5

The synthetic route of 485-71-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Itsuno, Shinichi; Yamamoto, Shunya; Takata, Shohei; Tetrahedron Letters; vol. 55; 44; (2014); p. 6117 – 6120;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

3922-40-5, 1,10-Phenanthroline-4,7-diol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the reaction flask by adding 4.2 g (0.02mol) 4,7-dihydroxy -1,10-phenanthroline, 3.4 g (0.02mol) copper chloride dihydrate, 20 ml anhydrous acetic acid, 5 ml water, heating reflux for 10 hours, still, to separate out the solid, the solid drying cocatalyst 4.0 g., 3922-40-5

3922-40-5 1,10-Phenanthroline-4,7-diol 77524, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Zhengzhou University; Li, RuiJun; Li, xueyang; Li, CaiJuan; Li, Jie; Yang, GuanYu; (8 pag.)CN104151133; (2016); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485-71-2,Cinchonidine,as a common compound, the synthetic route is as follows.

General procedure: The phase-transfer catalysts (C1-C11) were synthesized according to the proceduresbelow. To a solution of cinchonidine (1.00 g, 3.4 mmol) in THF (50 mL) was addedthe aryl benzyl bromides (3.4 mmol). The mixture was heated for 6-8 h at reflux.After cooling to room temperature, the mixture was poured into MTBE (150 mL)under stirring. The precipitated solid was filtrated and recrystallized fromCH3OH/MTBE to afford C1-C11, 485-71-2

485-71-2 Cinchonidine 101744, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Li, Ruipeng; Liu, Zhenren; Chen, Liang; Pan, Jing; Zhou, Weicheng; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1421 – 1427;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

18511-72-3, 4,4-dinitro-2,2-Bipyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The structural formula of the substituted bipyridine trivalent iron complex 4 described in this embodiment is as follows:Under an argon atmosphere, add anhydrous FeCl3 (64.9 mg, 0.4 mmol) to a 50 mL Schlenk bottle, and dissolve it in 6 mL of absolute ethanol at 60 C;A solution of 4,4′-dinitro-2,2′-bipyridine (98.5 mg, 0.4 mmol) in ethanol (4 mL) was added dropwise to the system. The reaction was carried out at 60 C for 1 hour.A brown complex was precipitated from the system, filtered, washed twice with cold ethanol, concentrated to remove the solvent, and dried under vacuum for 12 h to obtain a tan solid product 4, yield 67%.

18511-72-3, 18511-72-3 4,4-dinitro-2,2-Bipyridine 11519563, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Sciences Tsingtao Biological Energies And Process Institute; Wang Qinggang; Zhu Guangqian; Wang Liang; Zhang Xianhui; Jing Chuyang; (14 pag.)CN110305169; (2019); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

103946-54-9, 4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

87 mg of 4′-methyl- (2,2′-bipyridine) -4-carboxylic acid was dissolved in anhydrous THF and dissolved in anhydrous DMF. Under ice bath conditions, HOBt 55mg and DCC 100mg were completely dissolved and activated for 30min.The prepared HCl ¡¤ Arg (Tos) -Gly-Asp (OBzl) -Ser-OBzl 312 mg was added and the pH adjusted to 8.0-9.0 with DMM. The reaction was stirred at room temperature for 14h,The reaction was monitored by TLC plate. 328 mg (89% of product) of a pink solid powder was obtained., 103946-54-9

The synthetic route of 103946-54-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Capital University of Medical Sciences; Cui Chunying; Lin Na; (23 pag.)CN107320736; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

128143-89-5, 4′-Chloro-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The syntheses of ligands were carried out by literature procedures [48-50]. To a suspensionof KOH in dry DMSO at 50 C, ethylene glycol and its respective polymer (n = 2, 3, or 4)in excess were added. After stirring for 30 min, 4?-chloro-2,2? : 6?,2??-terpyridine was addedand the reaction mixture was stirred for 20 h at this temperature. Upon cooling to roomtemperature, the reacting mixture was treated with deionised water and filtered. The crudeproduct was extracted from the filtrate in dichloromethane (3 ¡Á 30 mL), dried overanhydrous magnesium sulfate, and then the solvent was removed., 128143-89-5

As the paragraph descriping shows that 128143-89-5 is playing an increasingly important role.

Reference£º
Article; Shaira; Jaganyi; Journal of Coordination Chemistry; vol. 67; 17; (2014); p. 2843 – 2857;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI