Tag: M.W:200-300

4568-71-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4568-71-2,3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride,as a common compound, the synthetic route is as follows.

1-(3-Methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanedione (compound 105) 3,4,5-Trimethoxyphenylvinylketone (4.8 g, 21.6 mmol), 3-methoxy-4-hydroxyethoxy-5-iodobenzaldehyde (5.7 g. 17.8 mmol), and 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride (1.9 g, 7.0 mmol) were stirred in triethylamine (20 mL) at 60¡ã C. for 16 hours. The reaction mixture was then acidified with 10percent HCl, and extracted with dichloromethane. The organic layer was dried over MgSO4, filtered and evaporated in vacuo. The product was purified in column chromatography (silica, 1:1 hexane/ethyl acetate) as a solid (9.7 g, 51percent). 1 H NMR (CDCl3) delta3.41 (m, 4H); 3.90 (m, 2H); 3.92 (s, 3H); 3.93 (s, 9H); 4.26 (t, 2H); 7.29 (s, 2H); 7.57 (d, 1H); 8.08 (d, 1H).

4568-71-2 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride 2833352, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Cytomed, Inc.; US5463083; (1995); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

66127-01-3,66127-01-3, 3-Bromo-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Compound 1: A mixture of 2-Br-phen (0.80 g, 3.10 mmol), 2-thiophenylboronic acid (0.42 g, 3.28 mmol), Pd(PPh3)4 (0.12 g, 0.10 mmol) and Cs2CO3 (3.03 g, 9.30 mmol) was dissolved in a mixture of dioxane (40 mL) and H2O (8 mL), placed into a degassed three-necked flask and refluxed under an argon atmosphere for 8 h. After the solution was cooled to room temperature, the solvent was removed under reduced pressure and the residue was dissolved in CHCl3 (50 mL), washed with excess water, and dried with anhydrous Na2SO4. The desired compound 1 was finally separated as light yellow solid by silica gel column chromatography using CHCl3/petroleum ether (v:v 5:1) as the eluent in a yield of 0.71 g (87%). Similarly, compounds 3 and L1 were obtained via the same synthetic method in the yields of 42 and 77%, respectively. Compound 3: 1H NMR (300 MHz, CDCl3) delta: 9.45 (d, 1H, J=2.3 Hz, phen), 9.20 (dd, 1H, J=4.4, 1.7 Hz, phen), 8.35 (d, 1H, J=2.3 Hz, phen), 8.25 (dd, 1H, J=8.1, 1.7 Hz, phen), 7.79 (s, 2H, phen), 7.64-7.57 (m, 2H, phenthienyl), 7.45 (dd, 1H, J=5.1, 1.1 Hz, thienyl), 7.20-7.18 (m, 1H, thienyl).

The synthetic route of 66127-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Peng, Yu-Xin; Xu, Dan; Wang, Na; Tao, Tao; Hu, Bin; Huang, Wei; Tetrahedron; vol. 72; 24; (2016); p. 3443 – 3453;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4568-71-2,3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Synthesis of ethyl 2-acetyl-3-(3-bromo-5-fluorophenyl)-4-(4-chlorophenyl)-4-oxobutanoate To a solution of ethyl-2-(3-bromo-5-fluorobenzylidene)-3-oxobutanoate (46.8 g, 148.5 mmol) and 4-chlorobenzaldehyde (21.4 g, 152.2 mmol) in ethanol (240 mL) was added triethylamine (31 mL, 222 mmol). Nitrogen gas was bubbled through the mixture for 5 min and 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride (6 g, 22 mmol) was then added. The mixture was heated to 70 C. for 2 h under a nitrogen atmosphere. The solvent was removed under vacuum and the residual crude was dissolved in EtOAc (700 mL) and washed with 1 M aqueous HCl (130 mL), water (2*150 mL) and brine (2*20 mL). The organic extract was dried over MgSO4, filtered and concentrated under vacuum to give ethyl 2-acetyl-3-(3-bromo-5-fluorophenyl)-4-(4-chlorophenyl)-4-oxobutanoate as an orange gum (73.1 g) which was used without purification. LCMS (ESI) [M+Na]+=477.0/479.0

4568-71-2, As the paragraph descriping shows that 4568-71-2 is playing an increasingly important role.

Reference£º
Patent; Unity Biotechnology; Beausoleil, Anne-Marie; Hudson, Ryan; (111 pag.)US2019/330250; (2019); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.787-70-2,[1,1′-Biphenyl]-4,4′-dicarboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of H2L (28.6mg, 0.1mmol), Cd(NO3)2¡¤4H2O (30.8mg, 0.1mmol), H2BPDA (24.2mg, 0.1mmol) and NaOH (8.0mg, 0.2mmol) in 10mL of H2O was sealed in a 16mL Teflon lined stainless steel container and heated at 180C for 3d. After the reaction mixture was cooled to room temperature, block crystals of 1 were collected with a yield of 32% by filtration and washed with water several times. Anal. Calc. for C32H22N4O4Cd: C, 60.15; H, 3.47; N, 8.77. Found: C, 60.52; H, 3.52; N, 8.85%. IR (KBr pellet, cm-1, Fig. S8): 1590 (s), 1573 (s), 1547 (s), 1543 (s), 1402 (m), 1126 (m), 1001 (m), 951 (s), 879 (m), 854 (w), 821 (m), 780 (m), 710 (w), 682 (w), 644 (w)., 787-70-2

As the paragraph descriping shows that 787-70-2 is playing an increasingly important role.

Reference£º
Article; Chen, Kai; Kang, Yan-Shang; Luo, Li; Zhao, Yue; Wang, Peng; Liu, Qing; Lu, Yi; Sun, Wei-Yin; Polyhedron; vol. 79; (2014); p. 239 – 249;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103946-54-9,4′-Methyl-[2,2′-bipyridine]-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Under anhydrous anaerobic conditions, 214 mg (1 mmol) of 4′-methyl-2,2′-bipyridinyl-4-carboxylic acid was added to 50 mL of bisChlorinated sulfoxide solvent, heated to 80 C reflux, stirring 3h after the reaction, the solvent spin to remove, the remaining solid dissolved in 50mL of anhydrous methylene chloride, 0 in the case of ice drop 244 mg (hydrazinocarbonyl) ferrocene and 130 muL of triethylamine in anhydrous dichloromethane was added dropwise. After completion of the dropwise addition, the reaction was stopped after stirring for 3 h in an ice bath. The reaction was quenched to room temperature, the solvent was removed by spin- (V: V = 40: 1), and the solvent was dried to give 4′-methyl-2,2′-bipyridyl-4- (hydrazinocarbonyl) bis Ferrocene, 103946-54-9

The synthetic route of 103946-54-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shaanxi Normal University; Zhang Chengxiao; Han Danjuan; Qi Honglan; (14 pag.)CN106892947; (2017); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

485-71-2, Cinchonidine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of (-)-cinchonidine (1.0 mmol) and benzyl bromide 3 (1.0 mmol) having sulfonamidegroup was stirred in DMF (4 mL) at 25 C for 20 h. After the reaction was completed, the reaction mixture was added dropwise to ether (50mL) with stirring. The solid precipitated was filtered,washed with ether (20 mL) and hexane (20 mL) to afford cinchonidinium salt 5

485-71-2, The synthetic route of 485-71-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Itsuno, Shinichi; Yamamoto, Shunya; Takata, Shohei; Tetrahedron Letters; vol. 55; 44; (2014); p. 6117 – 6120;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI