Tag: M.W:200-300

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Temple, Kayla J.; Engers, Julie L.; Long, Madeline F.; Gregro, Alison R.; Watson, Katherine J.; Chang, Sichen; Jenkins, Matthew T.; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W. researched the compound: 4-Bromo-2,5-dichloropyridine( cas:1184917-16-5 ).Quality Control of 4-Bromo-2,5-dichloropyridine.They published the article 《Discovery of a novel 3,4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping》 about this compound( cas:1184917-16-5 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: muscarinic acetylcholine receptor M4 pos allosteric modulator SAR; M(4); Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Structure activity relationship (SAR). We’ll tell you more about this compound (cas:1184917-16-5).

This Letter details our efforts to replace the 2,4-dimethylquinoline carboxamide core of our previous M4 PAM series, which suffered from high predicted hepatic clearance and protein binding. A scaffold hopping exercise identified a novel 3,4-dimethylcinnoline carboxamide core that provided good M4 PAM activity and improved clearance and protein binding profiles.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Product Details of 2834-05-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Electroinduced Reconfiguration of Complex Emulsions for Fabrication of Polymer Particles with Tunable Morphology. Author is Guo, Yongshun; Fang, Yanxiong; Jia, Kangle; Yu, Yue; Yu, Longfei; Li, Huanling; Zhang, Junjie; Zheng, Xiaoshan; Huang, Linjia; Wen, Wu; Mai, Yuliang.

Continuous morphol. control of anisotropic particles is always an important challenge in the field of materials. In this study, a new strategy for continuous fabrication of polymer particles with various morphologies induced by electricity is reported using complex emulsions as template. A synthetic electro-responsive surfactant containing ferrocene group is used to prepare complex emulsions, which contain a polymerizable monomer as inner phase. With the increasing time of elec. stimulation on the complex emulsions, hollow, hemispherical, mushroom-like, and spherical particles are constructed successively after photopolymerization The Marangoni effect caused by the heterogeneity in the interfacial tension at the droplet surface is the reason for the reconfigurable morphol. of the complex emulsion. The controllable complex emulsions by electricity present a versatile platform for constructing fine control of the microstructure and shape anisotropy of particles having customized shapes and functionalities, opening a new possibility for designing sophisticated architectures.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

HPLC of Formula: 2834-05-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Distinct twist-bend nematic phase behaviors associated with the ester-linkage direction of thioether-linked liquid crystal dimers. Author is Arakawa, Yuki; Komatsu, Kenta; Feng, Jun; Zhu, Chenhui; Tsuji, Hideto.

The twist-bend nematic phase (NTB) is a new spontaneous symmetry-breaking phenomenon observed in fluidic liquid crystal (LC) phases, which possesses a heliconical structure with a pitch ranging from several to tens of nanometers. Herein we demonstrate the distinct nano-to-macroscopic NTB phase behaviors associated with the ester-bond direction in two homologous series of sulfur-containing cyanobiphenyl-based LC dimers, viz. CBCOOnSCB and CBOCOnSCB (n = 2, 4, 6, 8, and 10). Both the series (excluding n = 2) formed NTB phases in which the homologues (n = 4 and 6) exhibited the NTB phases across a broad temperature range, which were observed to be stable even at room temperature and eventually formed NTB glasses. We found that both homologues (n = 4 and 6) displayed distinct phase-transition properties and optical textures with respect to the NTB phases. By performing tender resonant X-ray scattering measurements at the sulfur K-edge, we discovered their distinctly different nanoscopic helical pitch lengths. Within a similar shifted temperature, the pitches for CBOCOnSCB showed strong temperature dependence and were approx. double those of CBCOOnSCB, which exhibited significantly weaker temperature dependence. Compared to those of the representative twist-bend nematogenic dimers, the pitches of CBOCOnSCB and CBCOOnSCB are longer and shorter, resp. It is assumed that the mol. bend (or the mol. biaxiality) of LC dimers strongly influences the precession angle of the heliconical helix, and hence the resulting pitch. These findings provide new insights into the mol. designs to modulate the nanoscale helical pitches of the NTB phases.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Safety of 11-Bromoundecanoic acid. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Rhodium(I)-Catalyzed C2-Selective Decarbonylative C-H Alkylation of Indoles with Alkyl Carboxylic Acids and Anhydrides. Author is Yu, Haiyang; Zhao, Haoqiang; Xu, Xin; Zhang, Xin; Yu, Zexin; Li, Lingchao; Wang, Peng; Shi, Qian; Xu, Lijin.

A Rh(I)-catalyzed chelation-assisted C2-selective C-H decarbonylative alkylation of indoles with readily available, cheap, safe and structurally diverse alkyl carboxylic acids or anhydrides has been developed. A wide variety of primary and secondary alkyl carboxylic acids and differently substituted indoles are compatible with this transformation, allowing facile synthesis of various C2-alkylated indoles with high efficiency and broad tolerance of diverse functional groups. The reaction proceeds in the absence of any external oxidant, and the presence of readily installable and removable N-pyrimidyl directing group is critical for catalysis. The process is convenient and scalable, and avoids the use of a dried solvent and an inert atm. Moreover, selective C7-alkylation and C2, C7-dialkylation have also been achieved by slightly modifying the reaction conditions.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of C11H21BrO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Redox Control of Particle Deposition from Drying Drops. Author is Galy, Pauline E.; Guitton-Spassky, Tiffany; Sella, Catherine; Thouin, Laurent; Vitale, Maxime R.; Baigl, Damien.

The coffee-ring effect (CRE), which denotes the accumulation of nonvolatile compounds at the periphery of a pinned sessile drying drop, is a universal and ubiquitous yet complex phenomenon. It is crucial to better understand and control it, either to avoid its various deleterious consequences in many processes requiring homogeneous deposition or to exploit it for applications ranging from controlled particle patterning to low cost diagnostics. Here, we report for the first time the use of a reduction-oxidation (redox) stimulus to cancel the CRE or harness it, leading to a robust and tunable control of particle deposition in drying sessile drops. This is achieved by implementing redox-sensitive ferrocenyl cationic surfactants of different chain lengths in drying drops containing anionic colloids. Varying surfactant hydrophobicity, concentration, and redox state allows us not only to control the overall distribution of deposited particles, including the possibility to fully cancel the CRE, but also to modify the microscopic organization of particles inside the deposit. Notably, with all other parameters being fixed, this method allows the adjustment of the deposited particle patterns, from polycrystalline rings to uniform disks, as a function of the oxidation rate. We show that the redox control can be achieved either chem. by the addition of oxidants or electrochem. by applying a potential for additive-free and reversible actuation in a closed system. This correlation between the redox state and the particle pattern opens a perspective for both redox-programmable particle patterning and original diagnostic applications based on the visual determination of a redox state. It also contributes to clarify the role of surfactant charge and its amphiphilic character in directing particle deposition from drying suspensions.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Safety of 11-Bromoundecanoic acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Effect of different frying methods on flavor quality of pork chops. Author is Meng, Xiangren; Chen, Shengshu; Chen, Chang; Wang, Hengpeng; Wu, Peng; Tu, Mingliang; Gao, Ziwu.

In this paper, pork chops were used as research objects to analyze the effects of different frying methods (traditional, microwave, air fryer) on lipid oxidation and volatile flavor components. The results showed that the frying could promote the fat oxidation of pork. The oxidation value (POV) and thiobarbituric acid value (TBARS) of the pork chops were significantly increased after different frying methods (P<0.05). There was a significant difference in the degree of lipid oxidation between the pork chops of different frying methods (P<0.05). Among them, the microwave fried pork chops had the highest degree of lipid oxidation, followed by the air fryer, while the traditional fried samples had the lowest oxidation degree. In the traditional fried, microwave fried and air fryer fried pork chops samples, 54, 50, 53 kinds of volatile flavor substances were detected, among which the aldehydes were the main volatile components. There was no significant (P<0.05) difference in the relative content of total aldehydes among the three frying methods. Results: indicating that the air fryer had a high similarity to the traditional and microwave frying in the flavor quality of the pork chops. 2, 3-dimethylpyrazine having a baking aroma was detected in a sample of fried pork chops in the air fryer. I hope my short article helps more people learn about this compound(11-Bromoundecanoic acid)Safety of 11-Bromoundecanoic acid. Apart from the compound(2834-05-1), you can read my other articles to know other related compounds.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Basic copper carbonate, is researched, Molecular CH2Cu2O5, CAS is 12069-69-1, about Synergistic activation of sulfite for As(III) oxidation by basic copper(II) carbonate in homogeneous and heterogeneous processes at near-neutral conditions, the main research direction is copper carbonate arsenic catalytic oxidation density functional theory.HPLC of Formula: 12069-69-1.

Arsenic is categorized as a class I carcinogen due to its strong biol. toxicity. In this study, a novel treatment process with Cu2(OH)2CO3 as catalyst is proposed, whereby As(III) in water is oxidized by activating sulfite to generate SO4·- and SO4·- radicals. Under conditions of [Cu2(OH)2CO3]0 = 0.01 g·L-1, [sulfite]0 = 0.3 mmol·L-1, and initial pH 8.0, 94% of As(III) was converted into As(V) within 20 min, whereby dissolved oxygen had a pivotal impact on the reaction. However, HCO3-, humic acid, and fulvic acid all significantly inhibited the oxidation Heterogeneous electron transfer on the catalyst surface and homogeneous dissolved Cu2+ jointly activated sulfite in the Cu2(OH)2CO3/sulfite system, with the heterogeneous process predominating. D. functional theory (DFT) calculations disclose a dominate phys. adsorption of sulfite on Cu2(OH)2CO3 surface with 1.74 electrons transferred. >90% of As(III) was still oxidized after recycling the material five times, indicating excellent reusability. Overall, it shows good potential for application in the removal of As(III) from real water samples.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Application In Synthesis of 11-Bromoundecanoic acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about pH-Responsive Behavior of Pickering Emulsions Stabilized by a Selenium-Containing Surfactant and Alumina Nanoparticles. Author is Yu, Shijie; Lv, Miao; Lu, Guoping; Cai, Chun; Jiang, Jianzhong; Cui, Zhenggang.

Herein, we describe pH-responsive Pickering emulsions stabilized by a sodium carboxylate-derived selenium surfactant (C10-Se-C10·(COONa)2) in combination with pos. charged alumina nanoparticles. Unlike other bola-type carboxylate surfactants (e.g., disodium eicosanoate), C10-Se-C10·(COONa)2 is soluble in water with a low Krafft temperature (36.1 °C). The emulsions are sensitive to pH variations, and efficient demulsification can be achieved by a pH trigger. The carboxylic sodium group in the C10-Se-C10·(COONa)2 structure can be reversibly cycled between its anionic and nonionic states (carboxylic acid), resulting in a pH-controlled electrostatic attraction between the surfactant and alumina. The Pickering emulsion can be reversibly switched between “”on”” (stable) and “”off”” (unstable) states by pH at least four times. Compared with the emulsions stabilized by specially synthesized stimuli-responsive particles or surfactants, the method reported here is much easier to implement and requires very low concentrations of the surfactant and nanoparticles, with potential applications in the fields of biomedicine, drug delivery, and cosmetics.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein, the main research direction is esophageal cancer AML SHP2 PROTAC degrader ERK inhibition phosphorylation.Safety of 11-Bromoundecanoic acid.

Src homol. 2 domain-containing phosphatase 2 (SHP2) is an attractive therapeutic target for human cancers and other human diseases. Herein, we report our discovery of potent small-mol. SHP2 degraders whose design is based upon the proteolysis-targeting chimera (PROTAC) concept. This work has led to the discovery of potent and effective SHP2 degraders, exemplified by SHP2-D26. SHP2-D26(I) achieves DC50 values of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, resp., and is capable of reducing SHP2 protein levels by >95% in cancer cells. SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines. This study demonstrates that induced SHP2 degradation is a very effective approach to inhibit the function of SHP2. Further optimization of these SHP2 degraders may lead to the development of a new class of therapies for cancers and other human diseases.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Safety of 11-Bromoundecanoic acid. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Rhodium(I)-Catalyzed C2-Selective Decarbonylative C-H Alkylation of Indoles with Alkyl Carboxylic Acids and Anhydrides. Author is Yu, Haiyang; Zhao, Haoqiang; Xu, Xin; Zhang, Xin; Yu, Zexin; Li, Lingchao; Wang, Peng; Shi, Qian; Xu, Lijin.

A Rh(I)-catalyzed chelation-assisted C2-selective C-H decarbonylative alkylation of indoles with readily available, cheap, safe and structurally diverse alkyl carboxylic acids or anhydrides has been developed. A wide variety of primary and secondary alkyl carboxylic acids and differently substituted indoles are compatible with this transformation, allowing facile synthesis of various C2-alkylated indoles with high efficiency and broad tolerance of diverse functional groups. The reaction proceeds in the absence of any external oxidant, and the presence of readily installable and removable N-pyrimidyl directing group is critical for catalysis. The process is convenient and scalable, and avoids the use of a dried solvent and an inert atm. Moreover, selective C7-alkylation and C2, C7-dialkylation have also been achieved by slightly modifying the reaction conditions.

I hope my short article helps more people learn about this compound(11-Bromoundecanoic acid)Safety of 11-Bromoundecanoic acid. Apart from the compound(2834-05-1), you can read my other articles to know other related compounds.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI