Tag: M.W:300-400

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: [(C^N)2Ir(mu-Cl)]2 (small excess) and N^N ligand in CH2Cl2/CH3OH (20/4 mL) were stirred overnight at 40 C to give yellow/orange solution. It was evaporated. The residue was purified by column chromatography (silica, 20-25 g). Elution with 2.0-4.0% CH3OH in CH2Cl2 removed the impurities. Elution with 4.0-5.0% CH3OH in CH2Cl2 recovered the product as yellow or orange fraction. The product was preceded and/or followed by coloured/luminescent impurity fractions. The desired fractions were evaporated. The product was dissolved in CH3OH (4 mL), and added drop-wise to a stirred aqueous solution of KPF6 (1-1.3 g, 5.4-7.1 mmol, in 30 mL of water, large excess; Alfa Aesar) in order to convert the complex to a hexafluorophosphate salt. The resulting suspension was stirred for 30 min and filtered. Washed with water and ether. Anal. Calc. for C48H30F12IrN4P (MW 1113.95): C, 51.75; H, 2.71; N, 5.03. Found: C, 52.07; H, 2.84; N, 4.66%

1662-01-7, The synthetic route of 1662-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shavaleev, Nail M.; Scopelliti, Rosario; Graetzel, Michael; Nazeeruddin, Mohammad K.; Inorganica Chimica Acta; vol. 396; (2013); p. 17 – 20;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.130-95-0,Quinine,as a common compound, the synthetic route is as follows.

To a solution of quinine (78.2 mg, 0.2 mmol) in methanol (10 mL), a solution of ZnCl2 (27.2 mg, 0.2 mmol) in methanol (10 mL) was added. The mixture was stirred and heated at 50C for 2 h, and cooled to room temperature. The resulting solution was treated with aqueous HCl and filtered to remove staring materials. By slow evaporation of the filtrate at room temperature, white single crystals suitablefor X-ray diffraction were obtained after two weeks.The complex was identified as [(Quin)ZnCl3] (I). The yield was 78.8 mg (79.3%). IR (nu, cm-1): 3356 nu(OH), 3074 nu(CHar), 2971nu(CHaliph). For C20H25N2O2Cl3Zn anal. calcd., % C, 48.32 H, 5.07 N, 5.63Found, % C, 48.24 H, 5.02 N, 5.59, 130-95-0

The synthetic route of 130-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gu; Jia; Zhang; Russian Journal of Coordination Chemistry; vol. 44; 1; (2018); p. 52 – 58; Koord. Khim.; vol. 44; 1; (2018); p. 52 – 58,7;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139-07-1,N-Benzyl-N,N-dimethyldodecan-1-aminium chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 3 Preparation of 2-methoxybenzenesulfochloride A diazonium salt solution, prepared similarly to Example 1 from o-anisidine, was brought into intimate contact, at 0 C., with a solution of 100 ml of 1,2-dichloroethane and 21 g (0.33 mole) of SO2, and was then decomposed using 0.5 g of CuCl2 and 1 g of dodecyldimethylbenzylammonium chloride at 40 C. 4.3 g of a 30% strength by weight aqueous hydrogen peroxide solution (=38 millimoles of H2 O2) were then added to the mixture, and after a reaction time of 3 minutes the batch was worked up in a conventional manner. The yield of 2-methoxybenzenesulfochloride was 80%; boiling point 134-138 C./0.7 mbar.

139-07-1, As the paragraph descriping shows that 139-07-1 is playing an increasingly important role.

Reference£º
Patent; BASF Aktiengesellschaft; US4393211; (1983); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: Preparation of tert-butyl-(35)-3-[({[25,5R)-6-(sulfooxy)-7-oxo-l,6- diazabicylco[3.2.1]oct-2-yl]carbonyl}amino)oxy]pyrrolidine-l-carboxylate, tetrabutyl ammonium salt (VI): To a stirred solution of ieri-butyl(35)-3-[({ [25,5i?)-6-hydroxy-7-oxo-l,6- diazabicylco[3.2.1]oct-2-yl]carbonyl}amino)oxy]pyrrolidine-l-carboxylate (V) (8.04 g, 0.0217 mol) in dimethylformamide (50 ml), was added sulfur trioxide dimethyl formamide complex (3.98 g, 0.0260 mol) in one portion, at about 10C. The stirring was continued further for 30 minute and then the reaction mixture was allowed to warm to room temperature. After 2 hour, a solution of tetrabutylammonium acetate (7.83 g, 0.0260 mol) in water (25.8 ml) was added to the resulting reaction mass under stirring. After additional 2 hour of stirring, the solvent from the reaction mixture was evaporated under reduced pressure to obtain an oily residue. The oily mass was co-evaporated with xylene (2 x 20 ml) to obtain thick mass. This mass was partitioned between dichloromethane (100 ml) and water (100 ml). The organic layer was separated and the aqueous layer re-extracted with dichloromethane (50 ml). The combined organic extracts were washed with water (3 x 50 ml), dried over anhydrous sodium sulphate and the solvent evaporated under reduced pressure. The residual oily mass was triturated with ether (3 x 50 ml), each time the ether layer was decanted and finally the residue was concentrated under reduced pressure to obtain 11.3 g of tert-butyl(3S)-3-[({ [2S,5R)-6- (sulfooxy)-7-oxo-l,6-diazabicylco[3.2.1]oct-2-yl]carbonyl}amino)oxy] pyrrolidine- 1- carboxylate, tetrabutylammonium salt (VI), as a white foam, in 75 % yield. Analysis: Mass: 449.3 (M-l, without TBA); for Molecular weight of 691.94 and Molecular formula of C32H61N5O9S; and 1H NMR (400MHz, CDC13): 59.14-9.10 (d, 1H), 4.63 (s, 1H), 4.35 (s, 1H), 3.94- 3.92 (d, 1H), 3.66-3.35 (m, 5H), 3.29-3.27 (m, 8H), 2.83-2.80 (d, 1H), 2.35-2.17 (m, 3H), 1.98-1.87 (m, 2H), 1.73 (m, 1H), 1.70-1.62 (m, 8H), 1.49-1.40 (m, 17H), 1.02-0.99 (t, 12H).

10534-59-5, As the paragraph descriping shows that 10534-59-5 is playing an increasingly important role.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; BIRAJDAR, Satish; DOND, Bharat; PATIL, Vijaykumar Jagdishwar; PATEL, Mahesh Vithalbhai; WO2015/110886; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

56-54-2, General procedure: To a flame-dried flask equipped with a magnetic stirring bar and a condenser was added with cinchona alkaloids (1 mmol), toluene (5 mL), and benzyl bromide derivatives (1.2 mmol, 1.2 equiv.). The mixture was heated at 80 8C until a TLC analysis showing that the starting material was completely consumed. Cooled to room temperature and poured onto Et2O (30 mL) with stirring, the resulting suspension was stirred for another 1 h. Then the precipitate was purified by flash chromatography (MeOH/EtOAc = 1/10, V/V). 4.24.4 N-(2-F-4-Br-benzyl)quinidinium bromide (1d) Yield: 79%; white solid; m.p. 174-176 C (decomp.); [alpha]D28 +143.3 (c 0.14, CH3OH); IR (KBr): 3387, 3198, 3006, 1621, 1520, 1473, 1460, 1431, 1338, 1259, 1241, 1205, 1113, 1026, 851, 828, 719 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 8.81 (d, J = 4.4 Hz, 1H), 8.02 (d, J = 9.2 Hz, 1H), 7.87-7.76 (m, 3H), 7.67 (dd, J = 8.4, 1.6 Hz, 1H), 7.50 (dd, J = 9.2, 2.0 Hz, 1H), 7.41 (d, J = 2.4 Hz, 1H), 6.86 (d, J = 2.8 Hz, 1H), 6.51 (s, 1H), 6.03 (ddd, J = 17.2, 10.4, 6.8 Hz, 1H), 5.25-5.23 (m, 2H), 5.06 (d, J = 12.4 Hz, 1H), 4.77 (d, J = 12.4 Hz, 1H), 4.19 (t, J = 9.6 Hz, 1H), 4.06 (s, 3H), 3.97-3.85 (m, 2H), 3.44 (t, J = 11.2 Hz, 1H), 3.12 (q, J = 10.0 Hz, 1H), 2.68-2.62 (m,1H), 2.36 (t, J = 11.2 Hz, 1H), 2.00 (s, 1H), 1.82-1.75 (m, 2H), 1.10-1.03 (m, 1H); 13C NMR (100 MHz, DMSO-d6): delta = 162.1 (d, J = 252.2 Hz), 157.9, 147.9, 144.2, 143.8, 137.6, 131.9, 129.0, 125.8, 125.5 (d, J = 10.1 Hz), 121.9, 120.7, 120.3 (d, J = 25.7 Hz), 117.5, 115.4 (d, J = 13.7 Hz), 102.8, 67.9, 65.3, 56.8, 56.1, 54.7, 37.4, 26.6, 23.7, 21.0; HRMS calcd for [C33H35F6N2O2]+: 511.1391, found 511.1398.

The synthetic route of 56-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56-54-2,(S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol,as a common compound, the synthetic route is as follows.

General procedure: To a flame-dried flask equipped with a magnetic stirring bar and a condenser was added with cinchona alkaloids (1 mmol), toluene (5 mL), and benzyl bromide derivatives (1.2 mmol, 1.2 equiv.). The mixture was heated at 80 8C until a TLC analysis showing that the starting material was completely consumed. Cooled to room temperature and poured onto Et2O (30 mL) with stirring, the resulting suspension was stirred for another 1 h. Then the precipitate was purified by flash chromatography (MeOH/EtOAc = 1/10, V/V). 4.24.6 N-(3,5-Ditrifluoromethylbenzyl)quinidinium bromide (1f) [27] Yield: 85%; white solid; mp 177 C (decomp.); [alpha]D28 +176.1 (c 0.19, CH3OH); IR (KBr): 3394, 3201, 2954, 2664, 1622, 1509, 1473, 1432, 1374, 1281, 1214, 1226, 1178, 1135, 1027, 1005, 866, 905, 843, 828, 709, 682 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 8.82 (d, J = 4.8 Hz, 1H), 8.56 (s, 2H), 8.38 (s, 1H), 8.04 (d, J = 9.2 Hz, 1H), 7.77 (d, J = 4.4 Hz, 1H), 7.53 (dd, J = 7.2, 2.4 Hz 1H), 7.44 (d, J = 2.4 Hz, 1H), 6.78 (d, J = 3.2 Hz, 1H), 6.48 (s, 1H), 6.04 (ddd, J = 17.4, 10.2, 7.2 Hz, 1H), 5.28 (d, J = 2.8 Hz, 1H), 5.22 (d, J = 12.4 Hz, 2H), 5.01 (d, J = 12.8 Hz, 1H), 4.34 (t, J = 10.0 Hz, 1H), 4.10-4.13 (m, 1H), 4.06 (s, 3H), 3.80 (t, J = 9.4 Hz, 1H), 3.48 (t, J = 11.4 Hz, 1H), 3.04 (q, J = 9.6 Hz, 1H), 2.62 (q, J = 8.4 Hz, 1H), 2.42 (t, J = 11.6 Hz, 1H), 1.91 (s, 1H), 1.85-1.72 (m, 2H), 1.20-1.13 (m, 1H); 13C NMR (100 MHz, DMSO-d6): delta = 158.1, 147.9, 144.2, 143.7, 137.8, 135.1, 132.0, 131.7, 131.3 (q, J = 33.1 Hz), 130.1, 126.0, 125.0, 124.6 (q, J = 4.1 Hz), 123.7 (q, J = 271.3 Hz), 121.5, 120.9, 117.6, 103.1, 68.4, 65.2, 61.8, 56.3, 56.2, 54.7, 37.4, 26.9, 23.6, 21.1.

The synthetic route of 56-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

7173-51-5, N-Decyl-N,N-dimethyldecan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7173-51-5, Didecyldimethylammonium chloride (0.025 mol) was dissolved in 40 mL distilled water and the folic acid sodium salt (0.01 mol) was added. The solution was stirred at room temperature for 30 min. After separation of the phases, the organic phase was washed with distilled, cold water until chloride ions were no longer detected using AgNO3. The organic phase was separated and solvent was evaporated. The product (90% yield), didecyldimethylammonium N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoy]-L-glutamate, was dried at 50 C. under vacuum. Product is soluble in chloroform, acetone, DMSO. It lacks miscibility with water and hexane. 1H and 13C NMR (DMSO) were obtained. Thermogravimetric analysis: Tonset5%=153 C., and Tonset=201 C. 1H and 13C NMR (DMSO) were obtained.

As the paragraph descriping shows that 7173-51-5 is playing an increasingly important role.

Reference£º
Patent; Rogers, Robin D.; Daly, Daniel T.; Swatloski, Richard P.; Hough, Whitney L.; Davis, James Hilliard; Smiglak, Marcin; Pernak, Juliusz; Spear, Scott K.; US2007/93462; (2007); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7173-51-5,N-Decyl-N,N-dimethyldecan-1-aminium chloride,as a common compound, the synthetic route is as follows.,7173-51-5

General procedure: In a round-bottom flask equipped with dropping funnel and reflux condenser 0.01 mol of (4-chloro-2-methylphenoxy)acetic acid, 40 mL of distilled water and 0.011 mol of 10% aqueous solution of NaOH was heated at 50 C until the mixture became a clear solution. Then a stoichiometric amount of quaternary ammonium chloride was added and the mixture was stirred for 30 min at room temperature. The product deposited as the bottom layer, which was separated. Then it was dissolved in 50 mL of chloroform. The organic phase was washed with distilled water until no chloride was present in water. After removal of chloroform the product was dried under reduced pressure at 60 C for 24 h.

The synthetic route of 7173-51-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pernak, Juliusz; Syguda, Anna; Janiszewska, Dominika; Materna, Katarzyna; Praczyk, Tadeusz; Tetrahedron; vol. 67; 26; (2011); p. 4838 – 4844;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.448-61-3,2,4,6-Triphenylpyrylium tetrafluoroborate,as a common compound, the synthetic route is as follows.

General procedure: To a suspension of the corresponding amine (2.0 mmol) and 2,4,6-triphenylpyrylium tetrafluoroborate (2.0 mmol) in EtOH (20 mL) in a round bottle flask was added Et3N (2.0 mmol). The mixture turned deep-brown while the educts dissolved and was stirred for 30 min at rt followed by the addition of AcOH (4.0 mmol) and heating under reflux conditions for additional 2 h. The product precipitated during the reaction. The product was dissolved directly in the flask with little acetone at the reflux temperature after the reaction was finished (no further precipitate occurred). After cooling down to rt the product crystallized as a yellow solid, which was filtered off, washed with cold EtOH and pentane and dried in vacuo., 448-61-3

448-61-3 2,4,6-Triphenylpyrylium tetrafluoroborate 9930615, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Menzel, Roberto; Kupfer, Stephan; Mede, Ralf; Goerls, Helmar; Gonzalez, Leticia; Beckert, Rainer; Tetrahedron; vol. 69; 5; (2013); p. 1489 – 1498;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Stock 0.5M solution of EuCl3 was prepared by the treatment of Eu2O3(4.400 g, 12.50 mmol) by minimum amount of concentrated HCl in aquartz crucible. The resulting solution was evaporated to dryness at 90 Cand the residue was dissolved in a minimum amount of distilled water.After that, the solution was transferred quantitatively to a volumetric flaskand the volume was adjusted to 50 mL. This solution was then kept in apolypropylene flask. To a stirred warm (40 C) solution of the ligand(3 mmol) and (1 mmol) bathophenanthroline (0.33 g) in 30 mL of ethanol,2 mL of an 0.5M aqueous solution of EuCl3 (1 mmol) were added dropwise,followed by careful addition of 3 mL (3 mmol) of an 1.0M NaOHsolution in water until the pH of the mixture reached 6-7. The mixture washeated at 50 C during 4 h in a closed flask and cooled. Further operationsdepended upon the properties of the reaction products.

1662-01-7, 1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Korshunov; Ambrozevich; Taydakov; Vashchenko; Goriachiy; Selyukov; Dmitrienko; Dyes and Pigments; vol. 163; (2019); p. 291 – 299;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI