Tag: M.W:300-400

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The synthetic route of binary and ternary europium complexes C1-C5 is demonstrated in Scheme 2. A solution of EFBA (3 mmol) in ethanol was added dropwise to the aqueous solution of europium nitrate (1 mmol) with constant stirring on magnetic stirrer at room temperature. pH of the resulting mixture was set between 6-7 by using dilute NaOH (0.05 M) and white color precipitates were obtained. The resulting precipitates were vaccum filtered along with washing of water and ethanol to remove the unreacted ligand and then dried in vaccum desiccator to obtain the white powder of Eu(EFBA)3(H2O)2 (C1) complex. Complexes C2-C5 were prepared by the same procedure as adopted for the synthesis of complex C1 but in addition to the reaction mixture of EFBA (3 mmol) and europium nitrate (1 mmol) there is extra addition of ethanolic solution of neo (1 mmol), batho (1 mmol), phen (1 mmol), and bipy (1 mmol) for the synthesis of ternary europium complexes C2-C5, respectively., 1662-01-7

1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Devi, Rekha; Bala, Manju; Khatkar, S. P.; Taxak, V. B.; Boora, Priti; Journal of Fluorine Chemistry; vol. 181; (2016); p. 36 – 44;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10534-59-5,Tetrabutylammonium acetate,as a common compound, the synthetic route is as follows.

Step 4: Preparation of tetrabutylammonium salt of (2S,5R)-N-[(3/?)-l-(ferf-butoxycarbonyl) piperidine-3-carbonyl]-6-(sulfooxy)-7-oxo-l,6-diazabicyclo[3.2.1]octane-2-carboxamide: To a stirred solution of (2S,5 ?)-N-[(3^)-l-(ieri-butoxycarbonyl)piperidine-3-carbonyl]-6-hydroxy-7-oxo- l,6-diazabicyclo[3.2.1]octane-2-carboxamide (0.480 g, 0.0012mol) in dimethylformamide (4.8 ml), at about 10C, was added dimethylformamide sulphur trioxide complex (0.207 g, 0.0013mol) in one portion. The reaction mass was stirred at the same temperature for 30 minutes and allowed to warm to room temperature. After 1 hour of stirring, to the reaction mixture was added, slowly, a solution of tetrabutylammonium acetate (0.408 g, 0.0013 mol) in dichloro methane (2 ml) and the stirring continued further. After 1 hour, the solvent from the reaction mixture was evaporated under reduced pressure to obtain an oily residue. The oily mass was co-evaporated with xylene (2×10 ml) resulting in a thick mass. This mass was partitioned between dichloromethane (10 ml) and water (10 ml) for three times. The combined organic extracts were washed with water (3×10 ml), dried (over anhydrous sodium sulphate) and the solvent was evaporated under reduced pressure. The resulting oily mass was triturated with ether (3×10 ml), each time the ether layer was decanted and finally the residue was concentrated under reduced pressure to obtain 0.7 g of the titled product as white foam in 80% yield.Analysis:475.4 (M-l) as free acid; for Molecular Weight: 717.95 and Molecular Formula:

10534-59-5, The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; PATIL, Vijaykumar Jagdishwar; KALE, Amol; SHAIKH, Mohammad Usman; PATEL, Mahesh Vithalbhai; (65 pag.)WO2016/116788; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a ethanolic solution of CHME (0.82 g, 3 mmol) add an aqueous solution of Eu(NO3)3*H2O (0.33 g, 1 mmol) was added with constant stirring on magnetic stirrer. The solution was neutralized with 0.05 M NaOH solution and adjusted pH of mixture 7-8. The mixture was stirred for 3 h at 35 C and then allowed to stand for 1 h. During stirring white precipitates appeared, which were filtered and washed with doubly distilled water and then with ethanol to remove the free ligand, after that dried in air and then in vacuum desiccators. Finally the complex was dried at 50 C in hot air oven to obtain the complex. The obtained complex Eu(CHME)3*2H2O was white power with 86 %yield. The elemental analysis data for Eu(CHME)3.2H2O(C45H40O11Cl3Eu) was found (calc.) % C, 53.21 (53.24); H,4.06 (3.97); Eu, 14.92 (14.97)., 1662-01-7

1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

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Article; Nandal, Poonam; Khatkar; Kumar, Rajesh; Khatkar, Avni; Taxak; Journal of Fluorescence; vol. 27; 1; (2017);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

4733-39-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4733-39-5,2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

[CuI(MeCN)4](ClO4) (50mg, 0.15mmol), PPh3 (80.4mg, 0.30mmol) and Ph2dmp (60.7mg, 0.18mmol) in MeCN (15ml) are stirred at room temperature for 1h. Slow evaporation of a MeCN solution of 4 afforded analytically pure complex as yellow crystalline solid. Yield (93.4mg, 62.9%). Elemental analysis for C62H50ClCuN2O4P2: calcd. C 71.06, H 4.81, N 2.67%; found: C 71.12, H 4.90, N 2.62%. Selected IR (KBr, cm-1): v(Cl-O) 1110. ESI-MS (positive): m/z 947 (M+). 1H NMR (300MHz, CDCl3): delta 7.98 (s, 2H, Phen H); 7.60 (m, 6H, phenyl H); 7.57-7.53 (m, 4H, phenyl H); 7.44 (s, 2H, phen H); 7.38-7.42 (m, 6H, phenyl H); 7.26-7.21 (m, 24H, phenyl H); 2.31 (s, 6H, -CH3). 31P{1H} NMR (162MHz, CDCl3): delta 0.87 (s, PPh3). UV/Vis (CH3CN): lambdamax/nm (epsilon/mol-1dm3cm-1): 228 (68830), 287 (53890), 369 sh (3950).

4733-39-5 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline 65149, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Hu, Lin-Li; Shen, Chang; Chu, Wing-Kin; Xiang, Jing; Yu, Fei; Xiang, Ge; Nie, Yan; Kwok, Chun-Leung; Leung, Chi-Fai; Ko, Chi-Chiu; Polyhedron; vol. 127; (2017); p. 203 – 211;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13104-56-8,4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine,as a common compound, the synthetic route is as follows.

General procedure: MnCl2.4H2O (1 mmol) was dissolved in alcohol (10 mL), Ligand(1 mmol) was dissolved in CHCl3 and was added dropwise to the above solution with stirring at room temperature in 1 h. Then the solution was refluxed for 4 h. The mixture was allowed to stay overnight at -10C, after which the precipitate was filtered off, washed with diethyl ether, and dried under vacuum.

13104-56-8, As the paragraph descriping shows that 13104-56-8 is playing an increasingly important role.

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Article; Liu, Bingqing; Luo, Wei; Li, Haixia; Qi, Xiaoyun; Hu, Quanyuan; Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry; vol. 45; 8; (2015); p. 1097 – 1101;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1866-16-6, S-Butyrylthiocholine iodide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The method was adapted for measurement of very low cholinesterase activity in samples, high throughput screening and serial assays. Thus, measurements on enzyme samples of 10 mul were performed either in a Peltier thermostated spectrofluorimeter F-7100 (Hitachi Ltd.,Japan) using standard spectrofluorimetic cuvettes of 1 cm-path length in a total volume of 1.5 ml, or in a titration microplate reader (TecanInfinite F Plex) using a total volume of 200 mul per well (96-well titration plate, 7.5mm well ?). Stock solutions of substrates were 100mM ATC or BTC prepared inwater. These solutions were stored at -20 C. Because of thioester unstability, only freshly thawed solutions were used. Final substrate concentrations ranged between 2 and 1000 muM. Stock solution of Probe IV was 1mM made in DMSO and stored at -20 C. The solution is light sensitive. The final concentration of Probe IV in current assays was 10 muM. During the time-course of assays for determination of ChE activity, the fluorescence stops increasing when 1% of substrate is consumed, i.e. 10 muM thiocholine released. Thus, under steady-state conditions, [S] is almost constant and remains much larger than the enzyme concentration, i.e. >0.798mM for [S0]=800 muM. Then, the initial rate is linear until consumption of all probe. The final DMSO concentration in assay was 1% v/v. Though DMSO is known as a reversible ChE inhibitor (e.g. for human AChE,IC50=2.6% v/v in the presence of 1mM ATC), the inhibitory effect of 1% DMSO was considered as weak. The current volume of pure enzymes per assay was 15 mul in spectrofluorimetric cuvette and 10 mul per plate reader well. However, assays were also performed with sample volumes ranging from 5 to 30 mul. The final concentration in active sites per assay was as low as 10-12 M. For most kinetic studies, the active site concentration was 1.3¡Á10-10 M for BChE, 2.5¡Á10-11M for AChE, 3¡Á10-9M for BChE mutant E197Q and 1.5¡Á10-9M for mutant E197G. Measurements of activity were performed at the optimum pH of both enzymes and 25 C, the standard temperature for kinetic and thermodynamic studies. The rate of hydrolysis of ATC or BTC wasmonitored in 0.1M sodium phosphate buffer pH 8 for AChE and pH 7 for wild-type and mutants of BChE at 25 C for 3 min in spectrofluorimeter and for 2 min in microplate reader by the fluorescence emission of Probe IV-thiocholine conjugate (Scheme 2) (DeltaIF/dt) withlambdaex=400 nm and lambdaem =465 nm. On Hitachi spectrofluorimeter, lambdaex slit was 5.0 nm and lambdaem slit 10.0 nm. The Tecan titration plate readerwas equipped with light filters with bandwith of lambdaex ¡À 35 nm andlambdaem ¡À 35 nm. The fluorescence background of Probe IV was substracted. In addition, owing to the spontaneous hydrolysis of ATC and BTC, the fluorescence background due to spontaneous substrate hydrolysis was substracted for each concentration. Assays of human plasma BChE in a total volume of 2 ml were performed using 0.8mM BTC in 0.1M sodium phosphate buffer at 25 C. 1to 100 mul of plasma samples were taken for measurements using the classical Ellman’s method. For determination of BChE activity using the Probe IV method, plasma was diluted 100 or 1000 times in 0.1M phosphate buffer pH 7.0, and 1-100 mul samples of diluted plasma wereassayed in spectrofluorimeter. For both methods, reaction rates were recorded for 2 min.

1866-16-6, The synthetic route of 1866-16-6 has been constantly updated, and we look forward to future research findings.

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Article; Mukhametgalieva, Aliya R.; Zueva, Irina V.; Aglyamova, Aliya R.; Lushchekina, Sofya V.; Masson, Patrick; Biochimica et Biophysica Acta – Proteins and Proteomics; vol. 1868; 1; (2020);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 2.0 mmol of CoBr2*H2O, 2.0 mmol of H2bpb (1) and 4.0 mmol triethylamine were dissolved in 20 ml of DMF and stirred at RT and air for 20 min. Then 4.42 mmol of NEt4Br was added and the solution was stirred at RT and air an additional 12 h. DMF was removed in vacuo and the residue was dissolved in 30 ml of acetonitrile and filtered. Through adding 30 ml of diethyl ether to the solution and cooling down to 2 C a brown precipitate was formed. After filtering, washing with diethyl ether and drying under vacuo the product was yielded as a brown powder (56%). The complex is air-stable in the solid state and can be stored for months without degradation.

10534-59-5, As the paragraph descriping shows that 10534-59-5 is playing an increasingly important role.

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Article; Adolph; Zevaco; Walter; Dinjus; Doering; Polyhedron; vol. 48; 1; (2012); p. 92 – 98;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2,56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a flame-dried flask equipped with a magnetic stirring bar and a condenser was added with cinchona alkaloids (1 mmol), toluene (5 mL), and benzyl bromide derivatives (1.2 mmol, 1.2 equiv.). The mixture was heated at 80 8C until a TLC analysis showing that the starting material was completely consumed. Cooled to room temperature and poured onto Et2O (30 mL) with stirring, the resulting suspension was stirred for another 1 h. Then the precipitate was purified by flash chromatography (MeOH/EtOAc = 1/10, V/V). 4.24.2 N-(4-Trifluoromethylbenzyl)quinidinium bromide (1b) [25] Yield: 87%; white solid; mp 218 C (decomp.); [alpha]D28 +184.2 (c 0.15, CH3OH); IR (KBr): 3398, 3209, 2954, 1621, 1589, 1509, 1373, 1427, 1325, 1227, 1241, 1170, 1125, 1068, 1021, 1003, 934, 864, 832 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 8.82 (d, J = 4.4 Hz, 1H), 8.02 (d, J = 9.2 Hz, 1H), 7.97 (dd, J = 10.4, 9.2 Hz, 4H), 7.77 (d, J = 4.4 Hz, 1H), 7.51 (dd, J = 9.2, 2.4 Hz, 1H), 7.44 (d, J = 2.4 Hz, 1H), 6.84 (d, J = 3.6 Hz, 1H), 6.52 (s, 1H), 6.03 (ddd, J = 17.4, 10.5, 6.9 Hz, 1H), 5.25 (s, 1H), 5.10 (d, J = 8.4 Hz, 2H), 4.85 (d, J = 12.8 Hz, 1H), 4.28-4.22 (m, 1H), 4.06 (s, 3H), 4.02-4.00 (m, 1H), 3.86 (t, J = 9.4 Hz, 1H), 3.50 (t, J = 11.4 Hz, 1H), 3.00-2.90 (m, 1H), 2.69-2.63 (m, 1H), 2.40 (t, J = 11.4 Hz, 1H), 1.91 (s, 1H), 1.79-1.75 (m, 2H), 1.15-1.07 (m, 1H). 13C NMR (100 MHz, DMSO-d6): delta = 158.0, 147.9, 144.2, 143.8, 137.7, 135.1, 133.0, 131.9, 130.9 (q, J = 31.8 Hz), 126.4, 126.3, 125.9, 123.1, 121.7, 120.8, 117.5, 103.0, 68.1, 65.2, 62.9, 56.5, 56.2, 54.5, 37.2, 26.8, 23.6, 21.1.

56-54-2 (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol 637552, acatalyst-ligand compound, is more and more widely used in various fields.

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Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The pentafluorinated beta-diketone ligand (3 mmol), NaOH(0.12 g, 3 mmol) and the auxiliary ligand (1 mmol) were dissolved in 30 mL ethanol and heated to 60 C under stirring. Then, the ethanolic solution of EuCl3¡¤6H2O(1 mmol) was added dropwise, and the reaction mixture was stirred at 60 C for 8 h. After cooling down, the yellow solid was precipitated and filtered off. The solidproduct was washed with deionized water and ethanol, and dried in vacuum. Yellow powder, yield 75%, mp 180-182 C; IR nu (KBr):3027(m), 2922 (m), 2853 (m), 1592 (s), 1552 (s), 1506 (s), 1281 (s), 1187 (s), 1079(m), 928 (m), 783 (s), 588 (m), 507 (m) cm-1; 1H NMR (300 MHz, CDCl3):delta 2.98(s, 3H, C=CH), delta 3.23 (s, 18H, N(CH3)2), 6.58 (br, 6H, Ar-H), 7.57 (br, 6H, Ar-H),7.99 (br, 2H, Bath-H), 8.22 (br, 4H, Bath-H), 8.68 (br, 2H, Bath-H), 8.87 (br, 4H,Bath-H), 9.53 (br, 2H, Bath-H), 11.74 (br, 2H, Bath-H) ppm. Anal. Calcd. forEuC63H49N5O6F15:C, 53.70; H, 3.51; N, 4.97; Eu, 10.79; Found C, 53.47; H, 3.47;N, 5.02; Eu, 10.93., 1662-01-7

1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Wan, Yupeng; Lyu, Heng; Du, Hengyi; Wang, Dunjia; Yin, Guodong; Research on Chemical Intermediates; vol. 45; 4; (2019); p. 1669 – 1687;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

112881-51-3, 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: [Ru(1)(3)](PF6)2 was prepared according to the literature procedure.[16] Ru(1)Cl3 (0.10 g, 0.19 mmol) and ligand 3 (0.06 g,0.19 mmol) were suspended in ethane-1,2-diol (10 mL) and heated at reflux for 2 h. The red solution was cooled to room temperature and excess aqueous KPF6 was added. The resulting red precipitate was collected on Celite, dissolved in acetonitrile,and purified by column chromatography (SiO2, MeCN/H2O/saturated aqueous KNO3 14 : 1.2 : 0.5). The main red band was collected, excess aqueous KPF6 was added, and the solvent volume reduced to give a fine red precipitate, which was collected on Celite and washed with water (20 mL), ethanol (10 mL), and diethyl ether (20 ml). The residue was dissolved in MeCN and the solvent removed to give [Ru(1)(3)](PF6)2 as a red powder (0.07 g, 0.07 mmol, 36 %).

112881-51-3, As the paragraph descriping shows that 112881-51-3 is playing an increasingly important role.

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Article; Iranmanesh, Hasti; Arachchige, Kasun S. A.; Donald, William A.; Kyriacou, Niamh; Shen, Chao; Price, Jason R.; Beves, Jonathon E.; Australian Journal of Chemistry; vol. 70; 5; (2017); p. 529 – 537;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI