Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1662-01-7,4,7-Diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

1662-01-7, Under an argon atmosphere, [Cu(MeCN)4]-PF6 (58 mg) was added to dppb (64 mg) in a CH2Cl2 solvent.Then, dpp (50 mg) was added. The reaction mixture was stirredfor 15 min at room temperature. Diethyl ether was added to thesolution, and kept under refrigeration. The formed solid wasfiltered, and additional diethyl ether was added to the filtrateto form yellow solid, which was filtered, washed with diethylether, and dried in vacuo: yield, 57 mg (51%). 1H NMR (500MHz, acetone-d6) 9.06 (d, 4H, J = 5 Hz, phen), 8.07 (s, 4H,phen), 7.83 (d, 4H, J = 5 Hz, phen), 7.67.3 (m, 60H, Ph), 2.21(br).21 Anal. Found: C, 64.46; H, 4.20; N, 2.75%. Calcd. for 3,C104H88N4P6F12Cu2: C, 64.56; H, 4.58; N, 2.90.

1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Article; Nishikawa, Michihiro; Kakizoe, Daichi; Saito, Yuma; Ohishi, Tomoyuki; Tsubomura, Taro; Bulletin of the Chemical Society of Japan; vol. 90; 3; (2017); p. 286 – 288;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

55515-98-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55515-98-5,(R)-3,3′-Dimethyl-[1,1′-binaphthalene]-2,2′-diol,as a common compound, the synthetic route is as follows.

About 23 g (0.202 mol) of potassium t-butoxide was added to a solution of 30 g (0.109 mol) of (R)-3,31-dimethyl-2,2′-dihydroxy-1,1′-dinaphthyl and 62.0 g (0.101 mol) of ditosylate of 3,6,9,12-tetraoxa-8[(allyloxy)methyl]-1,14-tetradecanediol in 8 L of t-butanol and stirred under nitrogen at 25 C. The mixture was refluxed for 72 hours, cooled, and shaken with 500 ml each of CHCl3 and H2O. The organic layer was dried and evaporated under reduced pressure. The residue was purified on silica gel by elution with hexane and ethyl acetate starting from 50:1 and moving toward solely ethyl acetate. From this, 23.18 g of (R)-[13(allyloxy)methyl]-2,3,4,5-bis[1,2-(3-methylnaphto)]-1,6,9,12,15,18-hexaoxacycloeicosa-2,4-diene was obtained.

The synthetic route of 55515-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IBC Advanced Technologies, Inc.; US6686479; (2004); B2;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13104-56-8,4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine,as a common compound, the synthetic route is as follows.

General procedure: A mixtureof CuSO4 ¡¤ 5H2O (0.05 mmol, 0.0125 g), Meophtpy (0.1 mmol, 0.0340 g) and NaClO4 (0.1 mmol, 0.0122 g) in 95% EtOH (10 mL) were sealed in a 15 mL Telfon-lined stainless steel container, which was heated to 160C for 48 h. After cooling to room temperature at a rate of 5 K h-1, the green block crystals were obtained in about 55% yield based on Cu. IR (KBr; nu, cm-1): 3566.38 m, 3068.75 m,3014.74 m, 2935.66 m, 2839.22 m, 2015.61w,1869.02 w, 1600.92 v.s, 1575.84 s, 1544.98 s, 1519.91 s,1473.62 v.s, 1433.11 s, 1408.04 s, 1365.60 m,1307.74 m, 1280.73 m, 1246.02 v.s, 1184.29 v.s,1163.08 m, 1089.78 v.s, 1016.49 v.s, 831.47 m,831.32 v.s, 792.74 v.s, 746.45 m, 731.02 m, 688.59 m,657.73 m, 621.08 v.s, 582.50 s, 520.76 m, 472.56 m,455.20 m, 433.98 m, 414.70 m.

13104-56-8, As the paragraph descriping shows that 13104-56-8 is playing an increasingly important role.

Reference£º
Article; Fu; Cheng; Wang; He; Liu; Zhang; Russian Journal of Coordination Chemistry; vol. 43; 8; (2017); p. 547 – 558; Koord. Khim.; vol. 43; 8; (2017); p. 547 – 558,12;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Preparation of the [Ir(C^N)2(N^N)]3+[PF6-]3: in typical reaction procedure 0.10 g (0.058 mmol) of [{Ir(C^N)2Cl}2]4+[PF6]4, 0.04 g (0.16 mmol) AgPF6 and 0.03-0.06 g (0.19 mmol) of N^N ligand were heated at 100 C under argon in 15 ml of argon-purged 2-methoxyethanol/water mixture (8:2 v/v) for ca. 36 h. After cooling, the reaction mixture to ambient temperature, the precipitated AgCl was filtered off and the solvents were removed by rotary evaporation. The residue was dissolved in small amount of acetone and an excess of [NnBu4]Cl was added. The precipitate was filtered off and washed with acetone. The hexafluorophosphate salts were further obtained by anion metathesis with NH4PF6 in cold water with yields: [Ir(C^N)2(phen)]3+[PF6-]3 64%, [Ir(C^N)2(tmphen)]3+[PF6-]3 81%, [Ir(C^N)2(dpphen)]3+[PF6-]3 53%, [Ir(C^N)2(dpq)]3+[PF6-]3 42%, [Ir(C^N)2(dppz)]3+[PF6-]3 39%, [Ir(C^N)2(dppn)]3+[PF6-]3 57%. For the NMR data see Supporting information.

1662-01-7, The synthetic route of 1662-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kamecka, Anna; Grochowska, Olga; Kapturkiewicz, Andrzej; Inorganic Chemistry Communications; vol. 108; (2019);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.144222-34-4,N-((1R,2R)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide,as a common compound, the synthetic route is as follows.

[0219] To a solution of the enone (450 mg, 1 mmol, 1.0 equiv) in 0.5 M/4.5 mL/g anhydrous PhCH3 or dichloromethane (DCM) under N2 atmosphere was added Et3N (0.14 mL, 1 mmol, 1.0 equiv) and HCO2H (0.05 mL, 1.2 mmol, 1.2 equiv) at room temperature (RT). The resulting solution was stirred for 10 min and then treated with solid (R,R)-(-)-Ru-TsDPEN-cymene complex1 (19 mg, 0.03 mmol, 0.03 equiv) all at once. The reaction mixture was then aged at RT for 2 h, at which a complete consumption of starting material was observed. Tert-butyl methyl ether-MTBE (5 mL) was added followed by 1N HCl (2 mL). The organic layer was separated, washed with saturated Na2CO3, brine, dried over MgSO4, filtered and concentrated in vacuo to give the final compound as viscous oil. [0220] The catalyst can also be generated in situ by mixing 0.02 mol equiv of [RuCl2(p-cymene)2] and 0.04 mol equiv of the (R,R)-N-Tosyl-1,2-diphenylethylene-1,2-diamine in DCM (dichloromethane) in the presence of 0.04 mol equiv of 1M solution KOtBu in THF (tetrahydrofuran). After aging for 10 min at RT, Et3N was added followed by HCO2H and a solution of the enone in DCM). [0221] The catalyst was prepared by mixing 1 mol equiv of [RuCl2(p-cymene)2], 2 mol equiv (R,R)-N-Tosyl-1,2-diphenylethylene-1,2-diamine and 4.2 mol equiv of Et3N in iPrOH at 80 C. for 1 h (hour). After solvent removal, the solid was washed with cold H2O and the recrystallized from MeOH to give the catalyst as orange solid., 144222-34-4

As the paragraph descriping shows that 144222-34-4 is playing an increasingly important role.

Reference£º
Patent; Billot, Xavier; Colucci, John; Han, Yongxin; Wilson, Marie-Claire; Young, Robert N.; US2004/198701; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Step-2 product (100 mg, 0.268 mmol) in a mixture of dichloromethane and N,N’-dimethylformamide (250 mu?^ each) was added 10% palladium on carbon (25 mg) and the resulting mixture was stirred under hydrogen atmosphere for 1 hour at 25C to 35C. The catalyst was filtered through micron filter and the filtrate was concentrated under vacuum below 40C to provide a residue. The residue was dissolved in N,N-dimethylformamide (500 mu?^) and N,N-dimethylformamide sulfurtrioxide complex (50 mg, 0.321 mmol) was added in one lot at 0C temperature. The mixture was stirred for 1 hour. The aqueous tetrabutyl ammonium acetate solution (97 mg, 0.321 mmol dissolved in 350 mu?^ water) was then added to it. The reaction mixture was allowed to warm to 25C to 35C. and stirred further for 1 hour. The volatiles were removed under vacuum to provide a residue and residue was triturated with xylene (10 ml) to remove traces of N,N- dimethylformamide. Residue was partitioned between water (10 ml) and dichloromethane (10 ml). Aqueous layer was re-extracted with dichloromethane (10 ml). Combined organic extracts were washed with water (10 ml) and brine (10 ml). Organic layer was dried over sodium sulfate and concentrated under vacuum to obtain yellow oil as the Step-3 product, in 100 mg quantity (yield 62%). Analysis: MS: 361.2 (M-H) of free sulfonic acid; M.W: 603: M.F:

10534-59-5, The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WOCKHARDT LIMITED; BHAGWAT, Sachin; DESHPANDE, Prasad Keshav; BHAWASAR, Satish; PATIL, Vijaykumar Jagdishwar; TADIPARTHI, Ravikumar; PAWAR, Shivaji Sampatrao; JADHAV, Sunil Bhaginath; DABHADE, Sanjay Kisan; DESHMUKH, Vikas Vitthalrao; DHOND, Bharat; BIRAJDAR, Satish; SHAIKH, Mohammad Usman; DEKHANE, Deepak; PATEL, Piyush Ambalal; WO2013/30735; (2013); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139-07-1,N-Benzyl-N,N-dimethyldodecan-1-aminium chloride,as a common compound, the synthetic route is as follows.

Adopts the following conditions: Extracting the organic phase: The extractant: 0.4 mol/L; synergic reagent: 0.2 mol/L methyl trioctylphosphine ammonium chloride; diluent: chloroform. The aqueous phase: 0.4 mol/L LiCl; 0.5 mol/L NaOH; Axial center: 3:1; To 30 level enriching lithium isotope centrifugal extractor process test, after a long-term test operation, the extractant chemical stability is excellent, lithium isotope have realized multistage enrichment separation, from the initial7 Li isotope abundance 92.5%, after being enriched rose to 94.1%.

139-07-1, As the paragraph descriping shows that 139-07-1 is playing an increasingly important role.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Hu Jinbo; Zhang Wei; Zheng Weiqin; Shi Xiao; Xu Yongchang; Lv Honggui; Yuan Chengye; (20 pag.)CN104140379; (2017); B;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solutionof 5 (1 mmol, 1 eq.), 1-bromo-3,5-dimethoxybenzene(1.5 eq.), TBAA (6.0 eq.), Pd(OAc)2 (0.1 eq.) were dissolvedin 2 cm3 of NMP under an argon atmosphere. The wholewas heated at 110 C for 24 h. After cooling, a saturatedsolution of Na2CO3 was added and the resulting solutionwas extracted thrice with ethyl acetate. The organic layerswere then dried over Na2SO4 and evaporated to give anoil, from which residual NMP was evacuated using a lyophilizer.Chromatography of the resulting oil on silica geleluted with hexane/ethyl acetate (v/v: 60/40) gave 7 (tracesin these conditions). Further elution gave 6 in 75% yield asan orange oil. MS (ESI): m/z = 412.10 ([M+H]+); 1H NMR(400 MHz CDCl3):= 1.77 (s, 3H), 2.80 (t, 2H, J = 6.9 Hz),3.55 (s, 6H), 3.58 (s, 3H), 4.14 (t, 2H, J = 6.9 Hz), 5.29(s, 2H), 6.21 (d, 2H, J = 2.3 Hz), 6.46 (t, 1H, J = 2.3 Hz),6.72 (d, 2H, J = 8.7 Hz), 6.93 (d, 2H, J = 8.7 Hz) ppm; 13CNMR (100 MHz, CDCl3):= 20.7, 24.8, 51.5; 55.1, 55.3,63.3, 101.3, 107.6, 113.9,127.6,128.6, 128.8, 135.1, 141.6,159.3, 160.9, 170.6 ppm.

10534-59-5, As the paragraph descriping shows that 10534-59-5 is playing an increasingly important role.

Reference£º
Article; Praud-Tabaries, Annie; Bottzeck, Olivier; Blache, Yves; Monatshefte fur Chemie; vol. 150; 4; (2019); p. 649 – 654;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

115754-62-6, ((1,3-Dioxolan-2-yl)methyl)tributylphosphonium bromide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of 8a (0.18g, 1.44mmol) and 1,3-dioxolan-2-ylmethyltributylphosphonium bromide (10) (0.28g, 0.75mmol) in dry DMF (3mL) a 0.48M solution of sodium ethoxide in ethanol (1.5mL, 0.73mmol) was added under argon atmosphere. The mixture was stirred at 90C for 22h and then water (75mL) was added. The aqueous phase was extracted with AcOEt (4¡Á50mL), and the resulting organic layer was washed with brine, dried over MgSO4, and evaporated. To a solution of the crude residue in THF (10mL), an aqueous solution of HCl 1N (40mL) was added and the mixture was stirred for 90min at room temperature. Then, water (50mL) was added and the aqueous phase was extracted with AcOEt (4¡Á50mL). The organic layer was dried over MgSO4 and evaporated. The crude product was purified by flash column chromatography (silicagel) using CH2Cl2/ hexane (9:1) as eluent, yielding 8b (0.14g, 0.34mmol, 72%) as a dark red solid. Found: C 73.55, H 3.90. C27H18O2S2 requires C 73.94, H 4.14%. Mp 220-222C. IR (KBr, cm-1): 1651 (C=O), 1600 (C=C), 1552 (C=C). 1H NMR (300MHz, CDCl3): delta 9.63 (d, J=7.7Hz, 1H, -CHO), 7.89-7.83 (m, 2H, phenyl-H), 7.81-7.75 (m, 2H, phenyl-H), 7.61 (d, J=15.3Hz, 1H, -CH=CH-CHO), 7.54-7.40 (m, 7H, phenyl-H+TT-H), 7.16 (d, J=2.1Hz, 1H, pyranylidene-H), 7.08 (br s, 1H, pyranylidene-H), 6.48 (s, 1H, TT-H), 6.47 (dd, J1=15.3 Hz, J2=7.7Hz, 1H, -CH=CH-CHO), 6.14 (s, 1H, pyranylidene=C-H). 13C NMR (100MHz, CDCl3): delta 192.5, 185.9, 154.2, 151.9, 148.7, 145.0, 139.5, 133.0, 132.8, 130.5, 129.9, 129.4, 128.8, 128.7, 125.7, 125.1, 125.0, 124.8, 124.6, 116.5, 108.5, 107.6, 102.7. HRMS (ESI+): found 439.0804 [M+H]+. C27H19O2S2 requires 439.0821., 115754-62-6

As the paragraph descriping shows that 115754-62-6 is playing an increasingly important role.

Reference£º
Article; Marco, A. Belen; Andreu, Raquel; Franco, Santiago; Garin, Javier; Orduna, Jesus; Villacampa, Belen; Alicante, Raquel; Tetrahedron; vol. 69; 19; (2013); p. 3919 – 3926;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13465-09-3,Indium(III) bromide,as a common compound, the synthetic route is as follows.

13465-09-3, Step C: Methyl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)-5-methylpyridin-2-yl)-3-(3-(difluoromethyl)-8-methyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-2,2-dimethylpropanoate. InBr3 (228 mg, 0.643 mmol) was added to a 100 mL round-bottomed flask containing a solution of 7-((6-(((tert-butyldimethylsilyl)oxy)methyl)-5-methylpyridin-2-yl)chloromethyl)-3-(difluoromethyl)-8-methyl-[1,2,4]triazolo[4,3-a]pyridine (1.0 g, 2.1 mmol), ((1-methoxy-2-methylprop-1-en-1-yl)oxy)trimethylsilane (1.87 g, 10.7 mmol) and dichloromethane (30 mL) under N2. The resulting mixture was stirred at room temperature for 48 hours, then was poured into water (30 mL) and extracted with dichloromethane (30 mL*3). These extractions resulted in several organic solvent fractions which were combined, washed with brine (30 mL), dried over anhydrous Na2SO4, filtered, and concentrated to dryness under reduced pressure. The material was purified by FCC (petroleum ether/ethyl acetate=1:0 to 3:1) to give the title compound (460 mg, 37% yield). MS (ESI): mass calcd. for C27H38F2N4O3Si 532.3; m/z found, 533.3 [M+H]+.

As the paragraph descriping shows that 13465-09-3 is playing an increasingly important role.

Reference£º
Patent; Janssen Pharmaceutica NV; Barbay, J. Kent; Chai, Wenying; Hirst, Gavin C.; Kreutter, Kevin D.; Kummer, David A.; McClure, Kelly J.; Nishimura, Rachel T.; Shih, Amy Y.; Venable, Jennifer D.; Venkatesan, Hariharan; Wei, Jianmei; (501 pag.)US2020/55874; (2020); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI