Some tips on 167316-27-0

167316-27-0, As the paragraph descriping shows that 167316-27-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.167316-27-0,N-((1S,2S)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide,as a common compound, the synthetic route is as follows.

Under an atmosphere of argon, 134 mg (0.2 mmol) of [RuCl2(hexamethylbenzene)]2 147 mg (0.4 mmol) of (S,S)-TsDPEN, 183 mg (2.8 mmol ) of potassium hydroxide, 3 mL of methylene chloride, and 3 mL of water were placed in a 20 mL Schlenk tube and stirred at room temperature for 1 hour. The organic phase was washed with water several times, and sodium sulfate was then added to the organic phase to dry it. The organic phase was further dried with CaH2 and then filtered, the solvent was removed by distillation, and the residue was dried under vacuum. The violet crystals thus obtained were used directly in a reaction as a catalyst. By the same procedure as in Reference Example 1, Ru[(S,S)-Tsdpen] (1,2,3,4,5-pentamethylbenzene), Ru[(S,S)-Tsdpen] (1,2,4,5-tetramethylbenzene), Ru[(S,S)-Tsdpen] (1,3,5-trimethylbenzene), Ru[(S,S)-Tsdpen] (p-cymene), and Ru[(S,S)-Msdpen] (hexamethylbenzene) were synthesized. Furthermore, RuH[(R,R)-Tsdpen] (1,3,5-trimethylbenzene) was synthesized by carrying out the reaction of Reference Example 1 in 2-propanol.

167316-27-0, As the paragraph descriping shows that 167316-27-0 is playing an increasingly important role.

Reference£º
Patent; Kanto Kagaku Kabushiki Kaisha; EP1439159; (2004); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Analyzing the synthesis route of 1662-01-7

As the paragraph descriping shows that 1662-01-7 is playing an increasingly important role.

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1662-01-7, General procedure: The formerly reported protocol for the preparation of complex Ru-Cl [1] was modified,as described below, and this modification was used also for the Os(II) analogue Os-Cl. Thestarting dimer [M(mu-Cl)(eta6-pcym)Cl]2 (0.10 mmol; M = Ru or Os) reacted with an excess (0.15mmol) of bphen in 5 mL of MeOH in a microwave reaction system (100 C, 1 min). Theobtained solutions were cooled to ambient temperature, and an excess of NH4PF6 (3.0 mmol)was added. The solvent volume was reduced after 15 min of stirring at ambient temperature,until the solid formed. The obtained chlorido complexes [Ru(eta6-pcym)(bphen)Cl]PF6 (Ru-Cl)and [Os(eta6-pcym)(bphen)Cl]PF6 (Os-Cl) were collected by filtration, washed (1 ¡Á 0.5 mL ofMeOH and 3 ¡Á 1 mL of diethyl ether) and dried under vacuum.

As the paragraph descriping shows that 1662-01-7 is playing an increasingly important role.

Reference£º
Article; Starha, Pavel; Travni?ek, Zden?k; Van?o, Jan; Dvo?ak, Zden?k; Molecules; vol. 23; 2; (2018);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Some tips on 10534-59-5

The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of (25,5 ?)-Lambda^- [(5-ieri-butoxycarbonylamino-lH-tetrazol-l-yl)acetyl]-7-oxo-6-oxy-l,6-diazabicyclo[3.2.1] octane-2-carbohydrazide (4.65 g, 1.5 mmol, product from Step 6) in dimethylformamide (30 ml) was added dimethylformamide sulfur trioxide complex (2.76 g, 1.8 mmol) in one portion at 0C under argon atmosphere. The reaction mass was stirred at the same temperature for 30 minutes and allowed to attain ambient temperature. The reaction was monitored by thin layer chromatography using mixture of chloroform and methanol (9: 1) as solvent. After complete consumption of starting material tetrabutyl ammonium acetate (5.42 g, 1.8 mmol) dissolved in 20 ml of water was added to it at 25-30 C under stirring. The reaction was monitored by thin layer chromatography using mixture of chloroform and methanol (9: 1) as solvent. After complete consumption of starting material the volatiles were removed under reduced pressure. The residue was partitioned between dichloromethane (200 ml) and water (100 ml). The water layer was separated and organic layer washed with water (100 ml). The organic extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure to provide 7.8 g of tetrabutyl ammonium salt of (2S,5R)-6- (sulfooxy)-7-oxo-N’-(lH-tetrazol- l-ylacetyl)- l,6-diaza bicycle [3.2.1]octane-2-carbohydrazide in 82% yield. Analysis: 9.3 (M- l) for free acid; for Molecular weight: 631 and Molecular formula: CioHi3N807S. (400MHz, DMSO-d6): S 7.93 (s, 1H), 5.33 (s, 2H), 3.97 (bs, 1H), 3.83(m, 1H), 3.14-3.10 (m, 9H), 2.87(m, 1H), 2.11- 1.5 (m, 4H), 1.54 (m, 8H), 1.33- 1.24 (m, 8H), 0.93-0.89 (m, 12H)., 10534-59-5

The synthetic route of 10534-59-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WOCKHARDT LIMITED; TADIPARTHI, Ravikumar; PATIL, Vijaykumar Jagdishwar; DEKHANE, Deepak; SHAIKH, Mohammad Usman; BIRAJDAR, Satish; DOND, Bharat; PATEL, Mahesh Vithalbhai; (100 pag.)WO2017/81615; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Simple exploration of 1662-01-7

1662-01-7, 1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of 2,4,7-triphenyl-1,10-phenanthrolineTo a three-necked flask of 250 ml, 0.97 g (6.16 mmol) of bromobenzene and 70 ml of THF were charged, then 3.9 ml (22 mmol) n-butyllithium (1.6M in Hexane solution) was dropped under stirring at -78 C. in a nitrogen atmosphere. The mixture was stirred for one hour at -78 C., and a solution of 1.86 g (5.6 mmol) 4,7-diphenyl-1,10-phenanthroline in 30 ml THF was dropped. Then the mixture was stirred at room temperature for overnight and was added with water. The organic layer was extracted with Dichloromethane and dried with anhydrous magnesium sulfate, the solvent was removed by rotary evaporation. The product was purified by column chromatography on alumina using Dichloromethane/Hexane as eluent and dried in vacuo, obtaining white powder compound 0.85 g (yield of 37.21%).

1662-01-7, 1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Yen, Feng Wen; US2008/265746; (2008); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Brief introduction of 23616-79-7

23616-79-7, 23616-79-7 N-Benzyl-N,N-dibutylbutan-1-aminium chloride 159952, acatalyst-ligand compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23616-79-7,N-Benzyl-N,N-dibutylbutan-1-aminium chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 3 A 3-necked, 250 mL round-bottomed flask equipped with a reflux condenser and two pressure equalizing addition funnels was charged with 60 mL of a 30 percent by weight aqueous sodium hydroxide solution and 1.275 gram (4.1 mmol) of benzyltributylammonium chloride. 4-hydroxymethyl-2-methoxy-2-methyl-1,3-dioxolane (29.14 g, 196.7 mmol) and 25 g vinylbenzyl chloride (164 mmol) were simultaneously charged under a nitrogen atmosphere from the addition funnels into the flask over a 5 minute period. The reaction flask was immersed in an oil bath at 50 C. and the contents were stirred for 6 hours, then stirred at room temperature overnight. The organic phase was separated, diluted with methylene chloride (200 mL) and triethylamine (5 mL), washed with water, dried over anhydrous magnesium sulfate, and vacuum stripped. 42 g of 4-hydroxymethyl-2-methoxy-2-methyl-1,3-dioxolane vinylbenzyl ether were produced.

23616-79-7, 23616-79-7 N-Benzyl-N,N-dibutylbutan-1-aminium chloride 159952, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; General Electric Company; US5231197; (1993); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Simple exploration of 115754-62-6

115754-62-6 ((1,3-Dioxolan-2-yl)methyl)tributylphosphonium bromide 22292430, acatalyst-ligand compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115754-62-6,((1,3-Dioxolan-2-yl)methyl)tributylphosphonium bromide,as a common compound, the synthetic route is as follows.

5.0 g (0.02548 mol) of 3,4,5-trimethoxy benzaldehyde and 33 ml of a 1M solution of previously made Wittig Salt III [4] in dimethylformamide (DMF) (1.3 equivalents, 0.03312 mol) was added to 150 ml 95% EtOH under N2 and warmed to dissolve all solids. 19 ml 2M NaOEt (1.5 equivalents, 0.03822 mol) was added drop-wise, and the reaction was heated to 60 C. for 48 hours. The mixture was poured into 300 ml H2O, extracted with 3¡Á75 ml EtOAc, washed with 2¡Á40 ml H2O and 2¡Á40 ml brine, dried with MgSO4, and concentrated by rotary evaporation. The resulting yellow solids were added to 150 ml THF. 100 ml 2M HCl was added to this solution and stirred for one hour at 20 C. Most of the solvent was removed by rotary evaporation, and the remainder was poured into 100 ml H2O. The product was extracted, washed, and dried as before, giving 5.2 g of impure yellow oil. This oil was purified through a short silica gel column, eluting with CH2Cl2 giving 4.02 g of a yellow solid, (E)-4-(3,4,5-trimethoxyphenyl)but-3-en-2-one intermediate product. The total yield was 4.02 g or 71%.1H NMR (500 MHz, CDCl3), delta 9.66 (d, J=8 Hz, 1H), 7.37 (d, J=16 Hz, 1H), 6.77 (s, 2H), 6.62 (dd, J=16 Hz, J=8 Hz, 1H), 3.88 (s, 9H), 115754-62-6

115754-62-6 ((1,3-Dioxolan-2-yl)methyl)tributylphosphonium bromide 22292430, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Spangler, Brenda D.; Spangler, Charles W.; Tarter, E. Scott; US2009/43109; (2009); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

New learning discoveries about 1119-97-7

As the paragraph descriping shows that 1119-97-7 is playing an increasingly important role.

1119-97-7, MitMAB is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A 100mL round-bottom flask was equipped with a magnetic stir bar and a reflux condenser. To xylene (10.0mL), tetradecyltrimethylammonium bromide (1.1mmol) and a heterocyclic compound (1.0mmol) were added, followed bya solution of NaOH 50% (5.0 mL). The mixture was stirred at reflux temperature for 2-18 h. After completion of thereaction, the mixture was air-jet cooled to 25 C and TLC indicated the disappearance of the starting material. The reaction mix was treated with AcOEt (4 ¡Á 20 mL), and the organic phase separated and removed under reduced pressure. The residue was purified to analytical purity by column chromatography., 1119-97-7

As the paragraph descriping shows that 1119-97-7 is playing an increasingly important role.

Reference£º
Article; Gonzalez-Gonzalez, Carlos A.; Vega, Juan Javier Mejia; Monroy, Ricardo Garcia; Gonzalez-Calderon, Davir; Corona-Becerril, David; Fuentes-Benites, Aydee; Mascarua, Joaquin Tamariz; Gonzalez-Romero, Carlos; Journal of Chemistry; vol. 2017; (2017);,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Brief introduction of 39069-02-8

As the paragraph descriping shows that 39069-02-8 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39069-02-8,2,9-Dibromo-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

Reference Example 1(2,9-bis(6-((Methoxymethyloxy)methyl)pyridine-2-yl)-1,10-phenanthroline) (20)[0109] [Chem. 15] [0110] Under a stream of argon, 2,9-dibromo-1,10-phenanthroline (compound (10); 3.25 g; 9.6 mmol) was dissolved in anhydrous dimethylformamide (45 mL). To the reaction mixture, 2-methoxymethyloxymethylpyridine-6-yl tributyltin (compound (12); 17 g; 9.6 mmol) and triphenylphosphine palladium dichloride (3.83 g; 4.8 mmol) were added, followed by stirring at 70 oC for 22 hours. The reaction mixture was cooled to room temperature, and Rochelle salt was added thereto. Subsequently, the reaction mixture was poured into saline, and ethyl acetate was added thereto. Insoluble matters were filtered out, and the filtrate was extracted with ethyl acetate. The organic layer was washed with water and saturated saline, dried over anhydrous sodium sulfate, and then evaporated under reduced pressure to give oil matters. Under a stream of argon, the resulting oil matters were dissolved in anhydrous dimethylformamide (45 mL), and compound (12) (17 g; 9.6 mmol) and triphenylphosphine palladium dichloride (2.72 g; 3.38 mmol) were added thereto, followed by stirring at 70 oC for 20 hours. The reaction mixture was cooled to room temperature, and Rochelle salt was added thereto. Subsequently, the reaction mixture was poured into saline, and ethyl acetate was added thereto. Insoluble matters were filtered out, and the filtrate was extracted with ethyl acetate. The organic layer was washed with water and saturated saline, dried over anhydrous sodium sulfate, and then evaporated under reduced pressure to give a residue. The resulting residue was separated and purified by silica gel column chromatography (SiO2, 200 g; developing solvent: chloroform/methanol = 30/1 to 20/1 to 10/1), to give 1.1 g (yield: 23.7%) of the title compound (20).[0111] 1H NMR (DMSO-d6)d: 3.38 (s, 3 H), 4.80-4.83 (m, 8 H), 7.64 (d, J = 8 Hz, 2 H), 8.07-8.20 (m, 4 H), 8.65-8.84 (m, 4 H), 8.92 (d, J = 7 Hz, 1 H)HPLC mobile phase: 40-95% acetonitrile – water (0.1% trifluoroacetic acid)Peak retention time: 5.7 minutesESIMS (positive) m/z 483.1, (M+H) (F.W = 482.53 for C28H26N4O4), 39069-02-8

As the paragraph descriping shows that 39069-02-8 is playing an increasingly important role.

Reference£º
Patent; B.R.A.H.M.S GmbH; HOSHINO, Mikio; YANO, Toshisada; YAMANAKA, Yasukazu; WO2012/124310; (2012); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Some tips on 139-07-1

139-07-1, As the paragraph descriping shows that 139-07-1 is playing an increasingly important role.

139-07-1, N-Benzyl-N,N-dimethyldodecan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Solution A: A 5 mL volume of 160 mM sodium molybdate dihydrate is diluted with 5 mL of water and the acidity of the solution is adjusted to pH 2 with 0.1 M sulfuric acid. About 1 mL of 36% hydrogen peroxide is added and the resulting solution is diluted to 20 mL with water. Solution B: Oxalic acid dihydrate (0.106 grams) is added into 2.5 ml of an aqueous solution of alkyldimethylbenzylammonium chloride (0.604 grams) and the resulting solution is diluted to 5 mL with water. In an ice-cold condition with vigorous stirring, solution A is added dropwise into solution B and the pH of the resulting solution is maintained at pH 2 by adding sulfuric acid. After 5 minutes, the formation of the precipitate is observed. The reaction mixture is centrifuged and the precipitate is washed 2-3 times with water and dried under vacuum (yield of compound 3 was 85%).

139-07-1, As the paragraph descriping shows that 139-07-1 is playing an increasingly important role.

Reference£º
Patent; INDIAN INSTITUTE OF TECHNOLOGY MADRAS; CHAND, Dillip Kumar; CHAKRAVARTHY, Rajan Deepan; (16 pag.)US2016/251388; (2016); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Analyzing the synthesis route of 167316-27-0

167316-27-0 N-((1S,2S)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide 6612782, acatalyst-ligand compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.167316-27-0,N-((1S,2S)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide,as a common compound, the synthetic route is as follows.

Step 2 Scheme:- S, ? //–/N/ TEAF, I—) N 0 N 0 0 Compound 2 Compound 3 S-TsDPENMaterials : – Material Wt (g) MW Moles Equivs Compound 2 9 402. 79 0. 0224 1 DMF 39.5 73.09 0.54 24.16 (Rh Cp*C12) 2 0.0691 618.0 1. 12 x 104 5. 0 x 10-3 S, S-Ts DPEN 0.0817 366.0 2. 23 x 104 10. 0 x 10-3 DMF 7.5 73.09 0.103 4.59 TEAF 4. 65–2. 50 Cp* = pentamethylcyclopentadiene A 250 ML jacketed reactor set up with overhead stirrer, condenser, thermocouple and sparge pipe situated below the level of the agitator was assembled. The purified Compound 2 (9g) was charged to the reactor with DMF (39.5g). Freshly made catalyst (Rh CP*CI2) 2 (69.1 mg) and ligand S, S-Ts DPEN (N-p-toluenesulphonyl-1, 2- diphenylethylene-1, 2-diamine, 817 mg) in DMF (7.5g) was then charged. The contents were cooled to 10C and a nitrogen sparge rate of 1.2 L/min was established. The agitation was on full at 400 RPM. A solution of TEAF (triethylamine : formic acid mixture in 2: 5 mole ratio, 4.65 mis) was added drop-wise over 11.5 hrs overnight. The reaction was quenched with water (50MIS), a 15C exotherm (10-25C) was observed upon addition of the first 20 mis. The remaining 30 mis was added at <20C (bath temperature: 0C). Toluene was then charged (60 mis) at 20C. The reaction mass was agitated and allowed to settle respectively for 30 minutes each. The sparge was switched off at this point. The bottom red aqueous phase was back extracted with toluene (3X50M1S). The three resulting toluene phases were combined with the first black/brown organic phase. The combined reaction mass was concentrated down to a residual mass of 14.18g. The material obtained was then subjected to 3 repeats of the reduction and work up procedure, using freshly prepared catalyst for each repeat, to achieve 87% conversion, and a product mass of 7.8 g., 167316-27-0

167316-27-0 N-((1S,2S)-2-Amino-1,2-diphenylethyl)-4-methylbenzenesulfonamide 6612782, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; AVECIA LIMITED; WO2005/28437; (2005); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI