Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39069-02-8,2,9-Dibromo-1,10-phenanthroline,as a common compound, the synthetic route is as follows.,39069-02-8

To 1 mL of the solution of silver(I) tetrafluoroborate (1.17 mg, 0.00601 mmol) in dichloromethane was added 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (3.48 mg, 0.00601 mmol), and the mixture was stirred at room temperature for 15 minutes. Then, f23 (2.03 mg, 0.00601 mmol) was added to the reaction solution, which was stirred at 40C for five minutes. The reaction solution was subjected to recrystallization by slow diffusion of dichloromethane-ether and dried to provide 5.40 mg of the complex of the pale yellow crystal. [Show Image] The NMR data of the obtained complex is provided below. 1H NMR (300 MHz, CDCl3) delta 8.50 (brd, 2H), 8.13 (brs, 2H), 7.84 (brd, 2H), 7.62 (brd, 2H), 7.26-7.04 (m, 22H), 6.78 (br, 2H), 1.71 (s, 6H); 31P NMR (122 MHz, CDCl3); 31P NMR (122 MHz, CDCl3) delta -4.9 (d, J (31P-107Ag, 109Ag) = 392, 451 Hz). The composition of the obtained complex was determined according to the same method as in Example 15. The present complex corresponds to the above composition formula (5).

39069-02-8 2,9-Dibromo-1,10-phenanthroline 15448099, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,56-54-2

To a solution of epi-quinine (232 mg, 0.71 mmol) in DMSO (5 mL) was added LiH (11.1 mg, 1.1 mmol, 1.5 equiv) and the suspension was stirred for 1 h at room temperature. Then 2-chloro-1,10-phenanthroline (181 mg, 0.84 mmol, 1.2 equiv) was added and the mixture was stirred for 18 h at room temperature and 6 h at 80?85 ¡ãC. The cooled mixture was diluted with ethyl acetate (50 mL) and washed with brine (10 ¡Á 15 mL), the solvent was removed in vacuo, and the residue purified on silica gel (CHCl3 / MeOH 10:1) to afford 246 mg (67percent) of white solid.

As the paragraph descriping shows that 56-54-2 is playing an increasingly important role.

Reference£º
Article; Zieliska-Blajet, Mariola; Boratyski, Przemyslaw J.; Sidorowicz, Lukasz; Skarzewski, Jacek; Tetrahedron; vol. 72; 21; (2016); p. 2643 – 2648;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of a tetrabutylammonium salt of (2S,5R)-N-{[1-tert-butoxycarbonyl (2R, 4S)-4-(morpholin-4-yl)pyrrolidin-2-ylj methoxy } -6-hydroxy-7-oxo- 1,6- diazabicyclo[3.2.ljoctane-2-carboxamide (1.5 g, 0.0032 mol) in dimethylformamide (15 ml) was added sulfur trioxide: dimethylformamide complex (1.0 g, 0.0064 mol) under stirring at temperature of about 0 C. The reaction mixture was stirred at 0 C for 10 minutes and then allowed to warm to 25C. After 1 hr of stirring a solution of tetra butyl ammonium acetate (2.89 g, 0.0096 mol) in water (8 ml) was added to the reaction mixture under continuous stirring. After completion of 1 hr stirring the solvent from the reaction mixture was evaporated under reduced pressure to obtain an oily residue. The residue obtained was then purified by silica gel(60-120 mesh size) column chromatography using 6% Methanol: DCM mixture as an eluant to get required compound. The solvent of the combined fractions were evaporated to provide 1.2 g of the titled compound as white solid, 47% yield. Analysis:Mass: 548.4 (M-1) as free acid; for Molecular weight: 791.07 and Molecular formula:C37H70N60 ftS?H NMR (CDC13, 400 MHz): 5 10.42 (brs, 1H), 4.38-4.28 (m, 1H), 3.98-3.92 (m, 1H), 3.86- 3.68 (m, 5H), 3.62-3.52 (m, 1H), 3.42-3.20 (m, 1OH), 2.98-2.84 (m, 2H), 2.58-2.32 (m, 5H), 2.24-2.14 (m, 1H), 1.96-1.84 (m, 2H), 1.84-1.62 (m, 12H), 1.56-1.42 (m, 17H), 1.06-0.97 (m, 12H).

10534-59-5, 10534-59-5 Tetrabutylammonium acetate 82707, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; WOCKHARDT LIMITED; PATIL, Vijaykumar Jagdishwar; SHENGULE, Sudhir; PAWAR, Mangesh; BHUNIYA, Rajib; MUNSHI, Zaki Ahmed Burhanuddin; JOSHI, Prashant Ratnakar; TAKALKAR, Swapna Shripad; PATEL, Mahesh Vithalbhai; (64 pag.)WO2017/98425; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

1662-01-7, 4,7-Diphenyl-1,10-phenanthroline is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(Cmpd 12): 4,7-Diphenyl-2-(3-pyridyl)-1,10-phenanthroline. n-Butyllithium (18.8 ml of a 1.6 M solution in hexane, 0.03 mol) is added under argon to a cold (-78C) tetrahydrofurane (100 ml). 3-bromopyridine (4.75 g, 0.03 mol) is then added during 15 minutes while keeping the temperature at -78C. The brown solution is stirred 50 minutes at -78C, thereafter finely powdered 4,7-diphenyl-1,10-phenanthroline (6.64g, 0.02 mol) is added and the mixture is allowed to warm to room temperature during 40 minutes. Methanol (30 ml) is then added and the brown solution is evaporated on a rotary evaporator. The residue is dissolved in dichloromethane (300 ml) and methanol (10 ml), manganese dioxide (30 g) is added and the mixture is stirred at room temperature 12 h. The solids are removed by filtration, the filtrate is evaporated and the residue is crystallized from dichloromethane-ethanol and then o-dichlorobenzene to afford 2.1 g of the title compound. Light yellow, microcrystalline powder, mp (DSC in air, scan rate 10Cmin-1) = 268.3-273.5C. 1H-NMR (300 MHz, CD3Cl): 9.46 (d, J=1.8 Hz, 1H), 9.31 (d, J=4.5 Hz, 1H), 8.86 (d, J=11.7 Hz, 1H), 8.73 (d, J=6.6 Hz, 1H), 8.08 (s, 1H), 7.89 (s, 2H), 7.64-7.48 (m, 12H). MS for C29H19N3 (409.49) found M=409.69.

1662-01-7, 1662-01-7 4,7-Diphenyl-1,10-phenanthroline 72812, acatalyst-ligand compound, is more and more widely used in various fields.

Reference£º
Patent; BASF SE; EP2161272; (2010); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

56-54-2,56-54-2, (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a flame-dried flask equipped with a magnetic stirring bar and a condenser was added with cinchona alkaloids (1 mmol), toluene (5 mL), and benzyl bromide derivatives (1.2 mmol, 1.2 equiv.). The mixture was heated at 80 8C until a TLC analysis showing that the starting material was completely consumed. Cooled to room temperature and poured onto Et2O (30 mL) with stirring, the resulting suspension was stirred for another 1 h. Then the precipitate was purified by flash chromatography (MeOH/EtOAc = 1/10, V/V). 4.24.3 N-(9-Anthrylmethyl)quinidinium chloride (1c) [26] Yield: 80%; light yellow solid; m.p. 161 C (decomp.) (lit. mp 160 C, decomp.); [alpha]D28 +390.0 (c 0.12, CH3OH); IR (KBr): 3394, 3183, 1621, 1508, 1458, 1473, 1431, 1258, 1362, 1240, 1227, 1029, 922, 864, 744 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 8.98 (s, 1H), 8.86 (d, J = 4.4 Hz, 1H), 8.79 (d, J = 9.2 Hz, 1H), 8.70 (d, J = 9.2 Hz, 1H), 8.28 (dd, J = 8.2, 3.0 Hz, 2H), 8.05 (d, J = 9.2 Hz, 1H), 7.90 (d, J = 4.4 Hz, 1H), 7.82-7.74 (m, 3H), 7.69-7.64 (m, 3H), 7.53 (dd, J = 7.6, 2.4 Hz, 1H), 6.98 (s, 1H), 6.33 (d, J = 14.4 Hz, 1H), 6.03 (ddd, J = 17.2, 10.2, 7.2 Hz, 1H), 5.88 (d, J = 14.0 Hz, 1H), 5.18 (d, J = 10.4 Hz, 1H), 5.08 (d, J = 17.2 Hz, 1H), 4.46 (t, J = 9.2 Hz, 2H), 4.21 (s, 4H), 3.18 (t, J = 11.2 Hz, 1H), 2.62-2.54 (m, 1H), 2.46-2.35 (m,2H), 1.78 (s, 1H), 1.69 (d, J = 8.4 Hz, 1H), 1.56-1.53 (m, 1H), 1.10-1.04 (m, 1H); 13C NMR (100 MHz, DMSO-d6): delta = 157.9, 147.9, 144.3, 137.9, 133.5, 133.3, 132.5, 131.8, 131.7, 131.6, 130.2, 128.3, 128.0, 126.1, 126.0, 125.3, 125.0, 122.3, 121.0, 119.3, 117.5, 103.2, 67.9, 65.7, 56.5, 56.1, 55.8, 55.6, 37.7, 26.1, 24.2, 21.6.

As the paragraph descriping shows that 56-54-2 is playing an increasingly important role.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

13104-56-8, 4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of Ni(NO3)2.6H2O (0.070g, 0.24 mmol), meophtpy(0.078 g, 0.023 mmol) and NaClO4 (0.028 g, 0.023 mmol) inacetonitrile (30 mL) was sonicated for 10min. The resulted clearsolution was left alone until many brown crystals were obtained.Yield: 0.005g, 44.7%. Calcd. For C44H38Cl2N6NiO12 (1): C, 56.61;H, 4.17; N, 10.60%. Found: C, 56.76; H, 4.11; N, 10.67%. IR(KBr,cm1): 3066.82(w), 1600.92(vs), 1519.91(s), 1473.61(s), 1435.04(s), 1367.53(s), 1240.23(s), 1192.01(m), 1087.85(vs), 1024.20(s), 829.39(s), 794.67(vs), 729.09(m), 657.72(m), 621.08(m), 584.43(m), 518.85(m), 418.55(m).

13104-56-8, As the paragraph descriping shows that 13104-56-8 is playing an increasingly important role.

Reference£º
Article; Fu, Wei-Wei; Shen, Jing-Run; Tang, Zi-Qing; Peng, Yong-Qiong; Yi, Qing; Inorganic and Nano-Metal Chemistry; vol. 47; 12; (2017); p. 1664 – 1667;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.156492-30-7,4,7-Dibromo-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

[Re(CO)5Br] (247mg, 0.60mmol) and 4,7-Br2-phen(202mg, 0.60mmol) were stirred in toluene (25mL) until thereactants were dissolved completely. After refluxing the mixture for 2h under Ar-gas atmosphere, the solvent was removedunder reduced pressure. The crude product was washed with alarge amount of n-hexane, affording the facial-isomer of[Re(CO)3(4,7-Br2-phen)Br] as a dark yellow powder (408mg,91%). The purity of the complex was determined to be morethan 95% by 1HNMR, which was thought to be pure enough toemploy in the following reaction. 1HNMR (270MHz, CDCl3):delta/ppm 8.15 (d, 2H, J = 5.6Hz, 3,8-Ar-H), 8.46 (s, 2H, 5,6-ArH), 9.20 (d, 2H, J = 5.6Hz, 2,9-Ar-H). ESI-MS m/z 710([M+Na]+)., 156492-30-7

The synthetic route of 156492-30-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kang, Yuanyuan; Ito, Akitaka; Sakuda, Eri; Kitamura, Noboru; Bulletin of the Chemical Society of Japan; vol. 90; 5; (2017); p. 574 – 585;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13104-56-8,4′-(4-Methoxyphenyl)-2,2′:6′,2”-terpyridine,as a common compound, the synthetic route is as follows.

Co(NO3)2*6H2O (67 mg, 0.24 mmol), meophtpy (78 mg, 0.23 mmol), and NaClO4 (67.2 mg, 48 mmol) were dissolved in 30 ml of CH3CN. A few drops of water were added until the solution became clear. A crop of purple crystals was obtained in two weeks., 13104-56-8

As the paragraph descriping shows that 13104-56-8 is playing an increasingly important role.

Reference£º
Article; Fu; Shu; Luo; Tang; Li; Liu; Cheng; Wang; Liu; Journal of Structural Chemistry; vol. 59; 2; (2018); p. 398 – 410; Zh. Strukt. Khim.; vol. 59; 2; (2018); p. 412 – 424,13;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.943757-71-9,(R)-2-(Diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine,as a common compound, the synthetic route is as follows.

943757-71-9, To a solution of trans-cinnamaldehyde (134.2 g, 1.015 mol) in methanol (2 L), (2R)-2-[diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine (16.5 g, 50.6 mmol), nitroethanol (138.8 g, 1.524 mol), and benzoic acid (12.4 g, 101.5 mmol) were added, and the mixture was stirred at room temperature for 3 days under nitrogen atmosphere. Sodium bicarbonate (424.2 g, 5.05 mol) was added thereto, and the mixture was further stirred for 12 hours. The reaction solution was concentrated under reduced pressure, distilled water was added thereto, followed by extraction with ethyl acetate. The obtained organic layer was dried over sodium sulfate and filtered, and then the filtrate was concentrated under reduced pressure. After the residue was dissolved in a mixed solvent of ethyl acetate and hexane (1:1) under heating at 80C, the reaction solution was stirred and gradually cooled to room temperature. After 3 hours, the precipitated solid was filtered out to obtain (4R,5R)-4-phenyl-5-nitrotetrahydro-2H-pyran-2-ol (128.68 g, 0.576 mol, >99%ee).

943757-71-9 (R)-2-(Diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine 16218310, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; Sumitomo Dainippon Pharma Co., Ltd.; IKUMA Yohei; FUKUDA Nobuhisa; IWATA Masato; KIMURA Hidenori; SUZUKI Kuniko; EP2876105; (2015); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4733-39-5,2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline,as a common compound, the synthetic route is as follows.

General procedure: A mixture of (CBT)2Ir(m-Cl)2Ir(CBT)2 (0.84 g, 0.40 mmol) and1,10-phenanthroline (phen, 0.17 g, 0.84 mmol) in glycol (30 mL)wasstirred at 150 C in argon for 16 h. After being cooled to room temperature,an orange-red solution was obtained, and then 10 mLaqueous solution ofNH4PF6 (0.4 mol L1)was added in. The resultantorange floccules were filtered, washed withwater and then dried invacuum. The pure product was obtained by silica gel column chromatography,eluting with a mixture of CH2Cl2 and acetonitrile (10:1,volume ratio). Yield 90.3% (0.97 g, 0.72 mmol)

4733-39-5, The synthetic route of 4733-39-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tang, Huaijun; Chen, Zeyu; Wei, Liying; Miao, Jingsheng; Meng, Guoyun; He, Yonghui; Wu, Hongbin; Dyes and Pigments; vol. 131; (2016); p. 340 – 348;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI