Tag: M.W:300-400

23616-79-7, N-Benzyl-N,N-dibutylbutan-1-aminium chloride is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

b N-{5-(4-Chlorophenyl)pent-1-en-4-yl}-N-ethoxymethyl-3,5-dimethylbenzamide 2.36 ml (25.2 mmol) of chloromethyl ethyl ether are added in small portions over the course of 2 hours to a vigorously stirred solution of 5.5 g (16.8 mmol) of N-{5-(4-chlorophenyl)pent-1-en-4-yl}-3.5-dimethylbenzamide and 100 mg of benzyltributylammonium chloride in 15 ml of 50% strength aqueous sodium hydroxide solution and 15 ml of dichloromethane at 0-50. The organic phase is taken up in dichloromethane and water, the organic phase is separated off, dried over sodium sulfate and evaporated to dryness under reduced pressure. The oily residue is purified by chromatography on silica gel with ethyl acetate/hexane (1:4) as mobile phase; TLC (ethyl acetate/hexane; 1:3): Rf =0.50; 1H-NMR (300 MHz, CDCl3): mixture of rotamers, delta=7.31-7.18 (m, 4H), 7.04-6.85 (m, 2.6H), 6.42 (br. s, 0.4H), 5.92-5.60 (m, 1H), 5.20-5.02 (m, 2H), 4.54-4.24 (m, 2H), 3.96-3.67 (m, 1H), 3.25-2.40 (m, 6H), 2.28 (s, ca 5H), 2.24 (s, ca 1H), 1.34-1.21 (m, ca 0.5H), 1.08 (t, J=7, ca 2.5 H).

23616-79-7, 23616-79-7 N-Benzyl-N,N-dibutylbutan-1-aminium chloride 159952, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; Ciba-Geigy Corp.; US5310743; (1994); A;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.194800-56-1,[2,2′-Bipyridine]-4,4′-diyldiphosphonic acid,as a common compound, the synthetic route is as follows.

Dichloro-p-cymene ruthenium dimer (0.200 g, 0.320 mmol, 1.00 equiv.) was dissolved in degassed, dry DMF (122 mL). 4,4?-Bis(5-hexylthiophene-2-yl)-2,2?-bipyridin (0.310 g, 0.640 mmol, 2.00 equiv.) was added and the mixture was first stirred at 80 C for 4 h and then at room temperature for 12 h. Afterwards, dpbpy 7 (0.200 g, 0.640 mmol) was added and the reaction mixture stirred at 150 C for 4,5 h. After cooling to room temperature an excess of ammonium thiocyanate (2.02 g, 26.5 mol) was added, the mixture heated to 150 C and stirred for 4 h and then at room temperature for 12 h. The solvent was removed in vacuo, the crude product was precipitated with water, and subsequently purified by size exclusion chromatography on a Sephadex-LH 20 column. The desired complex was obtained as dark-red crystals (180.0 mg, 0.176 mmol, 27 %). 1H NMR (700 MHz, CD3OD): delta in ppm 8.96-8.92 (m, 2H), 8.83 (s, 1H), 8.13 (bs, 1H), 7.82 (d, J= 3.7, 1H), 7.74-7.73 (m, 1H), 7.70-7.62 (m, 4H), 7.54 (d, J= 6.3 Hz, 1H), 7.46 (dd, J= 6.0, 2.1 Hz, 1H), 7.37-7.335 (m, 1H). 7.17 (d, J= 5.8 Hz, 1H), 6.91 (d, J= 3.9, 1H), 2.86 (t, J= 7.6 Hz, 4H), 1.72 (p, J= 7.6 Hz, 4H), 1.42-1.31 (m, 12H), 0.90 (t, J= 7.0 Hz, 6H). 31P NMR (400 MHz; MeOD-d4): delta in ppm= 6.88 (s). HRMS (ESI) m/z: [M-2H]-2: calcd. for (C42H44N6O6S4P2Ru-2): 510.0367; found 510.0364. Anal. Calcd for RuC42H46N6O6P2S4: H, 4.54; C, 49.35; N, 8.22. Found: H, 5.01; C, 36.26; N, 5.64. IR (max, solid): 2921 nu(CH3), 2850 nu(H-O-P=O), 2096 nu(SCN), 1273 nu(NSC).

194800-56-1, The synthetic route of 194800-56-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Neuthe, Katja; Bittner, Florian; Stiemke, Frank; Ziem, Benjamin; Du, Juan; Zellner, Monika; Wark, Michael; Schubert, Thomas; Haag, Rainer; Dyes and Pigments; vol. 104; (2014); p. 24 – 33;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI

10534-59-5, Tetrabutylammonium acetate is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of a tetrabutylammonium salt of (2S,5R)-N-{[1-tert-butoxycarbonyl (2R, 4S)-4-(morpholin-4-yl)pyrrolidin-2-ylj methoxy } -6-hydroxy-7-oxo- 1,6- diazabicyclo[3.2.ljoctane-2-carboxamide (1.5 g, 0.0032 mol) in dimethylformamide (15 ml) was added sulfur trioxide: dimethylformamide complex (1.0 g, 0.0064 mol) under stirring at temperature of about 0 C. The reaction mixture was stirred at 0 C for 10 minutes and then allowed to warm to 25C. After 1 hr of stirring a solution of tetra butyl ammonium acetate (2.89 g, 0.0096 mol) in water (8 ml) was added to the reaction mixture under continuous stirring. After completion of 1 hr stirring the solvent from the reaction mixture was evaporated under reduced pressure to obtain an oily residue. The residue obtained was then purified by silica gel(60-120 mesh size) column chromatography using 6% Methanol: DCM mixture as an eluant to get required compound. The solvent of the combined fractions were evaporated to provide 1.2 g of the titled compound as white solid, 47% yield. Analysis:Mass: 548.4 (M-1) as free acid; for Molecular weight: 791.07 and Molecular formula:C37H70N60 ftS?H NMR (CDC13, 400 MHz): 5 10.42 (brs, 1H), 4.38-4.28 (m, 1H), 3.98-3.92 (m, 1H), 3.86- 3.68 (m, 5H), 3.62-3.52 (m, 1H), 3.42-3.20 (m, 1OH), 2.98-2.84 (m, 2H), 2.58-2.32 (m, 5H), 2.24-2.14 (m, 1H), 1.96-1.84 (m, 2H), 1.84-1.62 (m, 12H), 1.56-1.42 (m, 17H), 1.06-0.97 (m, 12H).

10534-59-5, 10534-59-5 Tetrabutylammonium acetate 82707, acatalyst-ligand compound, is more and more widely used in various.

Reference£º
Patent; WOCKHARDT LIMITED; PATIL, Vijaykumar Jagdishwar; SHENGULE, Sudhir; PAWAR, Mangesh; BHUNIYA, Rajib; MUNSHI, Zaki Ahmed Burhanuddin; JOSHI, Prashant Ratnakar; TAKALKAR, Swapna Shripad; PATEL, Mahesh Vithalbhai; (64 pag.)WO2017/98425; (2017); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI