Tag: M.W:300-400

HPLC of Formula: 89972-77-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis, structure, and DNA binding studies of copper(II) complexes of terpyridine derivatives.

Two Cu(II) complexes, [Cu(ttpy)2](ClO4)2 (1, ttpy = 4′-(p-Tolyl)-2,2′:6′,2”-terpyridine) and [Cu(Brphtpy)2](ClO4)2 (2, Brphtpy = 4′-p-Bromophenyl-2,2′:6′,2”-terpyridine), were synthesized and characterized for their DNA binding and cleaving ability. The crystal structure of complex 1 reveals an axially compressed six-coordinate geometry around Cu(II). In spite of having an axially compressed geometry, the polycrystalline EPR spectrum of complex 1 at 298 K shows g‖ > g⊥, indicating a dx2-y2 ground state for the Cu(II) complex. Both complexes 1 and 2 bind to CT DNA intercalatively with moderate binding strength (Kb = (8.4 ± 0.2) × 103 and (10.9 ± 0.2) × 104 M-1 (1 M = mol dm-3), resp.). Both of these complexes cleave plasmid DNA efficiently in the presence of peroxide.

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COA of Formula: C22H17N3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Novel functional architectures via metallo-supramolecular initiators. Author is Schubert, Ulrich S.; Heller, Marcel; Hochwimmer, Georg.

Functionalized terpyridine metal complexes were used as metallo-supramol. initiators for the living cationic polymerization of 2-oxazolines. This method allows an easy and very controlled synthesis of polymers containing terpyridine enfunctionalized polymers.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A Near-Infrared Neutral pH Fluorescent Probe for Monitoring Minor pH Changes: Imaging in Living HepG2 and HL-7702 Cells, published in 2009-03-04, which mentions a compound: 89972-77-0, Name is 4-(p-Tolyl)-2,2:6,2-terpyridine, Molecular C22H17N3, Name: 4-(p-Tolyl)-2,2:6,2-terpyridine.

A near-neutral pH near-IR (NIR) fluorescent probe utilizing a fluorophore-spacer-receptor mol. framework that can modulate the fluorescence emission intensity through a fast photoinduced electron-transfer process was developed. The authors’ strategy was to choose tricarbocyanine (Cy), a NIR fluorescent dye with high extinction coefficients, as a fluorophore, and 4′-(aminomethylphenyl)-2,2′:6′,2”-terpyridine (Tpy) as a receptor. The pH titration indicated that Tpy-Cy can monitor the minor physiol. pH fluctuations with a pKa of ∼7.10 near physiol. pH, which is valuable for intracellular pH researches. The probe responds linearly and rapidly to minor pH fluctuations within the range of 6.70-7.90 and exhibits strong dependence on pH changes. As expected, the real-time imaging of cellular pH and the detection of pH in situ was achieved successfully in living HepG2 and HL-7702 cells by this probe. It is shown that the probe effectively avoids the influence of autofluorescence and native cellular species in biol. systems and meanwhile exhibits high sensitivity, good photostability, and excellent cell membrane permeability.

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Metal catalyst and ligand design,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine(SMILESS: CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1,cas:89972-77-0) is researched.Formula: C5H6O2. The article 《High yield preparation of 4′-(4-bromophenyl)-2,2′:6′,2″”-terpyridine by a condensation reaction. Determination of the stereochemistry of two complex byproducts by a combination of molecular mechanics and NMR spectroscopy》 in relation to this compound, is published in Acta Chemica Scandinavica. Let’s take a look at the latest research on this compound (cas:89972-77-0).

An improved high yield synthesis of 4′-(4-bromophenyl)-2,2′:6′,2″”-terpyridine from 2-acetylpyridine (I) and 4-bromobenzaldehyde (II) has been developed, using a two-step aldol condensation. In this, the intermediate azachalcone was isolated, then reacted with N-[2-oxo-2-(2-pyridyl)ethyl]pyridinium iodide, prepared from I, using ammonium acetate both as a base and as a ring closure agent. It could also be shown that one step aldol condensation of I and II gave low yields of the desired terpyridine due to facile formation of polycondensation products. Two of these, cyclohexanes III and IV, could be isolated in moderate yields from condensation reactions. The structure and relative configuration of these compounds were determined by a comparison of observed exptl. NMR parameters with theor. values, calculated by mol. mechanics.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

COA of Formula: C22H17N3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about One pot synthesis of formyl benzyl terpyridine: a simplified synthesis. Author is Gurung, Anup; Dahal, Sanjay.

Formyl Ph terpyridine was synthesized from Me Ph terpyridine using SeO2 as the oxidizing agent. SeO2 conventionally was used to oxidize allylic and aliphatic Me groups. The simple conversion of Me group attached to aromatic ring appended to heterocycle in a clean one pot synthesis paved way for synthesis of similar aldehydes extendable to other classes of compound as well.

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Metal catalyst and ligand design,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 89972-77-0, is researched, SMILESS is CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1, Molecular C22H17N3Journal, Article, Angewandte Chemie, International Edition called Self- and directed assembly of hexaruthenium macrocycles, Author is Newkome, George R.; Cho, Tae Joon; Moorefield, Charles N.; Baker, Gregory R.; Cush, Randy; Russo, Paul S., the main research direction is ruthenium benzenebisterpyridine complex macrocycle self assembly preparation; terpyridine benzenebis ruthenium complex macrocycle self assembly.SDS of cas: 89972-77-0.

The bis(terpyridyl) ligands 5-bromo- and 5-methyl-benzene-1,3-diylbis-4′-(2,2′:6′,2”-terpyridine) were prepared and complexed with ruthenium to give mono- and dinuclear complexes which were self-assembled into hexaruthenium macrocycles. The ligands, complexes and macrocycles were characterized by elemental analyses and 1H NMR, UV and mass spectroscopy.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Quality Control of 4-(p-Tolyl)-2,2:6,2-terpyridine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Synthesis and co-crystallization behavior of copper(II) complexes of two isomeric p-tolyl-terpyridines. Author is Bray, David J.; Clegg, Jack K.; Jolliffe, Katrina A.; Lindoy, Leonard F.; Wei, Gang.

Cu(II) complexes incorporating the isomeric tolyl-derivatized terpyridine ligands, 4′-p-tolyl-2,2′:6′,2”-terpyridine (L1) and 6′-p-tolyl-2,2′:2”,4′-terpyridine (L2) were prepared and characterized by x-ray diffraction. The 1st of these is a co-crystal [Cu(L1)(NO3)2]·[Cu(L1)(NO3)(EtOH)]NO3·MeOH while the 2nd is a single complex [Cu(L2)2(NO3)]NO3·0.5MeOH·1.5H2O. Crystallization of a mixture of both products from EtOH/MeOH (1:1) yields an unusual co-crystalline product [Cu(L2)2NO3]2[Cu(L1)(NO3)2](NO3)2 whose structure was also confirmed by an x-ray structure determination

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Effect of substituent of terpyridines on the DNA-interaction of polypyridyl ruthenium(II) complexes.COA of Formula: C22H17N3.

An octahedral complexes of ruthenium with 2,9-dimethyl-1,10-phenanthroline (dmphen) and substituted terpyridine were synthesized. The RuII complexes were characterized by elemental analyses, thermogravimetric analyses, magnetic moment measurements, FTIR, electronic, 1H NMR and FAB mass spectra. The binding strength and mode of interaction of the complexes with Herring Sperm DNA was studied using absorption titration and viscosity measurement studies. Results suggest that the substituent on terpyridine ligand affects the binding mode and binding ability of the complexes. Effect of time and ionic strength on DNA cleavage ability of complex also was studied by gel electrophoresis. Results suggest that >200 mM concentration of NaCl decreases the cleavage ability of complex.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 89972-77-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about Phenyl-substituted 2,2′:6′,2”-terpyridine as a new series of fluorescent compounds-their photophysical properties and fluorescence tuning. Author is Mutai, Toshiki; Cheon, Jin-Dong; Arita, Shinpei; Araki, Koji.

Several phenyl-substituted 2,2′:6′,2”-terpyridines (tpy) were synthesized and it was found that 4′-Ph tpy (I) exhibited the most effective fluorescence, whose quantum yield was up to 0.64 in cyclohexane. For further study on tuning the fluorescence properties, different substituents were introduced into the p-position of the Ph group. While some dyes showed their absorption and fluorescence in the same region as I, others were observed at much longer wavelengths. In addition, fluorescence maxima of some of the dyes showed a large (>130 nm) solvent dependence. The difference between ground and excited state dipole moments (Δμ) for one dye was estimated to be 15.2 D by the Lippert-Mataga equation, indicating an intramol. charge transfer (ICT) process. Semi-empirical MO calculation (MOPAC/AM1) demonstrated that the HOMO-1, HOMO, and LUMO of I and several other dyes were mainly localized on the Ph (πph), tpy (πtpy) and tpy (π*tpy) part, resp., indicating that the lowest energy absorption band of these dyes was the local excitation (πtpy-π*tpy). In the case of dyes having an electron-donating substituent, πph instead of πtpy became the HOMO. Thus, the lowest energy absorption these dyes was an ICT transition (πph-π*tpy), and a large red shift of the fluorescence occurred. In these compounds, the energy level of πph is controlled without affecting that of πtpy and π*tpy, suggesting a novel approach for tuning the color of fluorescence.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Recommanded Product: 89972-77-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine, is researched, Molecular C22H17N3, CAS is 89972-77-0, about The surprising lability of bis(2,2′:6′,2”-terpyridine)chromium(III) complexes. Author is Constable, Edwin C.; Housecroft, Catherine E.; Neuburger, Markus; Schoenle, Jonas; Zampese, Jennifer A..

The complex [Cr(tpy)(O3SCF3)3] (tpy = 2,2′:6′,2”-terpyridine) is readily made from [Cr(tpy)Cl3] and is a convenient precursor to [Cr(tpy)2][PF6]3 and to [Cr(tpy)(4′-(4-tolyl)tpy)][PF6]3 and [Cr(tpy)(5,5”-Me2tpy)][PF6]3 (4′-(4-tolyl)tpy = 4′-(4-tolyl)-2,2′:6′,2”-terpyridine; 5,5”-Me2tpy = 5,5”-dimethyl-2,2′:6′,2”-terpyridine); these are the first examples of heteroleptic bis(tpy) chromium(III) complexes. The single crystal structures of 2{[Cr(tpy)2][PF6]3}·5MeCN, [Cr(tpy)(4′-(4-tolyl)tpy)][PF6]3·3MeCN and [Cr(tpy)(5,5”-Me2tpy)][PF6]3·3MeCN have been determined Each cation contains the expected octahedral {Cr(tpy)2}3+ unit; in all three structures, the need to accommodate three anions per cation and the solvent mols. prevents the formation of a grid-like array of cations that is typical of many lattices containing {M(tpy)2}2+ motifs. Three reversible electrochem. processes are observed for [Cr(tpy)(4′-(4-tolyl)tpy)][PF6]3 and [Cr(tpy)(5,5”-Me2tpy)][PF6]3, consistent with those documented for [Cr(tpy)2]3+. At pH 6.36, aqueous solutions of [Cr(tpy)2][PF6]3 are stable for at least two months. However, contrary to the expectations of the d3 Cr3+ ion being a kinetically inert metal center, the tpy ligands in [Cr(tpy)2]3+ are labile in the presence of base; absorption and 1H NMR spectroscopies have been used to monitor the effects of adding NaOH to aqueous and CD3OD solutions, resp., of the homo- and heteroleptic complexes. Ligand dissociation is also observed when [Bu4N]F was added to CD3OD solutions of the complexes, but in aqueous solution, [Cr(tpy)2][PF6]3 is stable in the presence of fluoride ion.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI