Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about The conversion of racemic terminal epoxides into either (+)- or (-)-diol γ- and δ-lactones.
Epoxidation of Et 4-pentenoate and kinetic resolution of the epoxide with (R,R)-(salen)Co(OAc) complex catalyst gave Et (R)-(+)-4,5-epoxypentanoate and (S)-(+)-γ-hydroxymethyl-γ-butyrolactone in high ees. ET 5-hexenoate similarly gave Et (R)-(+)-5,6-epoxyhexanoate, (S)-(-)-5,6-dihydroxyhexanoate, and (S)-(+)-δ-hydroxymethyl-δ-valerolactone. (S)-(-)-4,5-epoxypentanoate and (R)-(-)-γ-hydroxymethyl-γ-butyrolactone were obtained by using the (S,S)-(salen)Co(OAc) complex.
This compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI