Reference of 4378-13-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4378-13-6, Name is H-Thr(tBu)-OH, molecular formula is C8H17NO3. In a Article，once mentioned of 4378-13-6
We report broad guidance on how to catalyze enantioselective aldehyde additions to nitroalkene or maleimide Michael electrophiles in the presence of unprotected acidic spectator groups, e.g., carboxylic acids, acetamides, phenols, catechols, and maleimide NH groups. Remarkably, these l-threonine and l-serine potassium salt-catalyzed reactions proceed even when the nucleophilic and electrophilic Michael partners simultaneously contain acidic spectator groups. These findings begin to address the historical non-compatibility of enantioselective catalytic reactions in the presence of acidic moieties and simultaneously encroach on the spectator group tolerances normally associated with cellular environments. A carboxylate salt bridge, from the catalyst enabled enamine to the Michael electrophile, is thought to facilitate the expanded Michael substrate profile. A practical outcome of these endeavours is a new synthetic route to (R)-Pristiq, (?)-O-desmethylvenlafaxine, an antidepressant, in the highest yield known to date because no protecting groups are required. (Figure presented.).
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4378-13-6
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI