Electric Literature of 15862-18-7, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.15862-18-7, Name is 5,5′-Dibromo-2,2′-bipyridine, molecular formula is C10H6Br2N2. In a article£¬once mentioned of 15862-18-7
Preparation of novel substituted haloarene compounds
This invention relates to a new process for the preparation of novel substituted haloarene compounds of the formula I or IV: [image] respectively, wherein R1, R2, R3, R4, R5, X, and Y are as defined herein, that comprises a novel and efficient selective mono-lithiation of a dihaloarene of the formula II or V: [image] respectively, by an organo-lithium compound in the presence of a carbonyl reactant of the formula III: [image] wherein R1 and R2 are as defined herein. In the process of the instant invention, the newly formed lithiated haloarene is sequentially quenched in situ by the carbonyl reactant to form said substituted haloarene. The process is suitable for batch or continuous flow systems. The substituted haloarenes produced by the process of the present invention are useful intermediates in the preparation of N-aryl or N-heteroaryl substituted pharmaceutically active compounds that include selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors useful in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which a 5-HT1 agonist or antagonist is indicated.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 15862-18-7, and how the biochemistry of the body works.Electric Literature of 15862-18-7
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI