Reference of 91804-75-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.91804-75-0, Name is 1,10-Phenanthroline-5-carbaldehyde, molecular formula is C13H8N2O. In a Article£¬once mentioned of 91804-75-0
Two ruthenium complexes containing a new phenanthroline-based ligand pai (pai = 2-(5-(1, 10- phenanthroline))-1H-acenaphtho[1?,2?:4,5]imidazole) were synthesized and characterized. Two ruthenium complexes were found to cleave DNA under irradiation, interact with CT-DNA by intercalation. Furthermore, DNA topoisomerase inhibition experiments indicated that complex 2 exhibited higher topoisomerase I inhibition activity (IC50 = 10 muM) than complex 1 (IC50 = 40 muM). Molecular modeling studies revealed that complex 2 stabilized Top1cc complex via pi-pi interaction and the formation of hydrogen bond. The cytotoxicity of complexes 1 and 2 against Eca-109 and A549 cells was also evaluate by MTT method, indicating that complex 2 exhibited good anticancer activity against Eca-109 cells (IC50 = 17.23 ¡À 0.22 muM), but two ruthenium complexes displayed weak anticancer activity against A549 cells.
The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 91804-75-0 is helpful to your research. Reference of 91804-75-0
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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI