Chemistry is traditionally divided into organic and inorganic chemistry. name: Hydroquinine. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 522-66-7
Asymmetric organocatalytic alpha-amination of 2-oxindoles with bis(2,2,2-trichloroethyl)azo-dicarboxylate
An enantioselective electrophilic amination of 3-substituted-2-oxindoles is reported, using bis(2,2,2-trichloroethyl)azo-dicarboxylate and commercially available Cinchona alkaloid organocatalysts. The best results were obtained in the reaction of 3-aryl substrates, with high to excellent yields (75% to quantitative) and good stereoselectivity (64?77% ee). Facile reductive conversion of the protected 3-hydrazino fragment into the corresponding primary amine was also demonstrated, to expand the synthetic flexibility of asymmetric electrophilic amination with azo-dicarboxylic esters en route to enantioenriched 3-amino-2-oxindoles. The absolute configuration of 3-amino-3-phenyl-2-oxindole was independently established by electronic circular dichroism (ECD), combined with time-dependent density functional theory (TDDFT).
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: Hydroquinine, you can also check out more blogs about522-66-7
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI