Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ HPLC of Formula: C21H22N2O2S, Which mentioned a new discovery about 144222-34-4
Catalytic Asymmetric Synthesis of All Possible Stereoisomers of 2,3,4,6-Tetradeoxy-4-Aminohexopyranosides
We recently developed a divergent strategy for the synthesis of all eight possible 2,3,6-trideoxyhexopyranosides with three stereogenic centers. However, the diastereoselectivity for one of the three stereogenic centers was low and it was not controlled by catalysts. In this update, we described a systematic method for the first catalytic asymmetric synthesis of all eight possible 2,3,6-trideoxyhexopyranosides and all eight possible 2,3,4,6-tetradeoxy-4-aminohexopyranosides. The products derived from this strategy include the glycone of natural products grecocycline A, spinosyn A, and ossamycin. All three stereogenic centers in each product was controlled by a pair of chiral catalysts. The key to the success is the application of our recently developed dynamic kinetic stereodivergent acylation of Achmatowicz rearrangement products and chiral catalyst-directed reduction. Simple dimethylation of the 2,3,4,6-tetradeoxy-4-amino sugars afforded derivatives of naturally occurring beta-D-forosaminide and beta-L-ossaminide. (Figure presented.).
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 144222-34-4, help many people in the next few years.HPLC of Formula: C21H22N2O2S
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI