Electric Literature of C5H8O3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Multi-Gram Scale Synthesis of Chiral 3-Methyl-2,5-trans-tetrahydrofurans. Author is Qin, Shuanglin; Cao, Yuting; Luo, Yunhao; Jiang, Shende; Clark, J. Stephen; Wang, Xiaoji; Yang, Guang.
In this article, we report the rapid and facile synthesis of chiral 3-methyl-2,5-trans-tetrahydrofurans. This reaction utilizes cheap and easily available starting materials. A domino hydrolysis and intramol. Michael-type ring closure reaction was the key step. As a result, synthesis of the desired 3-methyl-2,5-trans-tetrahydrofurans could be achieved in gram-scale over seven linear steps with high chem. yield and high diastereoselectivity.
Although many compounds look similar to this compound(32780-06-6)Electric Literature of C5H8O3, numerous studies have shown that this compound(SMILES:O=C1O[C@H](CO)CC1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI