In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Diastereoselective synthesis of 2,5-disubstituted tetrahydrofuran derivatives, published in 2000-09-22, which mentions a compound: 32780-06-6, mainly applied to diastereoselective synthesis THF, Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.
5-Substituted lactol I was converted to 2,5-disubstituted THF derivatives by a Lewis acid-promoted reaction with allylsilanes. High trans selectivity (12:1) was obtained when hindered allylsilane Me2C:CHCH2SiMe3 was employed. Addnl., 2,5-cis-disubstituted THF derivatives were obtained in good yields and diastereoselectivities after alkyllithium addition to a lactone, followed by Et3SiH/BF3·OEt2 reduction of the corresponding hemiketals.
In some applications, this compound(32780-06-6)Application In Synthesis of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI