Formula: C5H6O2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5,6-Dihydro-2H-pyran-2-one, is researched, Molecular C5H6O2, CAS is 3393-45-1, about Anti-inflammatory and Quinone Reductase-Inducing Compounds from Beilschmiedia mannii. Author is Ahoua, Angora Remi Constant; Monteillier, Aymeric; Borlat, Frederic; Ciclet, Olivier; Marcourt, Laurence; Nejad Ebrahimi, Samad; Kone, Mamidou Witabouna; Bonfoh, Bassirou; Christen, Philippe; Cuendet, Muriel.
Previous studies on the therapeutic potential of plant species found in the diet of chimpanzees living in tai national park have shown that they could be potential candidates for the search of new mols. useful for humans. Based on the screening of some of these plants, the fruits of beilschmiedia mannii, whose dichloromethane extract showed cancer chemopreventive properties, were selected. Bioactivity-guided fractionation of the extract resulted in the isolation and identification of two pyrones, including desmethoxydihydromethysticin ( 1), found in a natural source for the first time, and a new congener, beilschmiediapyrone ( 2), as well as five known alkamides ( 3 – 7). Their structures were established by using nmr spectroscopy and mass spectrometry methods. The isolated compounds were evaluated for their cancer chemopreventive potential by using quinone reductase induction and nuclear factor-kappa b inhibition tests in hepa 1c1c7 and hek-293/nf- b-luc cells, resp. Among them, compounds 1and 2were the most active. The concentrations to double the quinone reductase activity were 7.5 mum for compound 1and 6.1 mum for compound 2. Compounds 1and 2inhibited nuclear factor-kappa b with ic 50values of 2.1 and 3.4 mum, resp. These results are promising with regard to cancer chemoprevention, especially because this plant is also used for cooking by the local population around the tai forest.
Although many compounds look similar to this compound(3393-45-1)Formula: C5H6O2, numerous studies have shown that this compound(SMILES:O=C1C=CCCO1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI