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Chiral Anion Directed Asymmetric Carbocation-Catalyzed Diels-Alder Reactions
In recent years the carbocation has re-emerged as a highly efficient Lewis acid catalyst for a variety of organic transformations. However, the goal of asymmetric carbocation catalysis has so far been out of reach mainly as a result of difficulties associated with the preparation of stable chiral carbocations. Here, we describe developments towards asymmetric carbocation catalysis based on the concept of chiral-anion-directed catalysis. Chiral tritylium salts can be conveniently prepared in situ by mixing trityl chloride derivatives with chiral phosphonate, phosphoramide, bis(sulfonyl)amide, and bis(sulfuryl)amide silver or sodium salts. It is shown that the bis(sulfuryl)amide/tritylium ion salt catalyzes the Diels-Alder reaction with an up to 53 % enantiomeric excess. The enantioenriched triphenylmethylium/bis(sulfuryl)amide contact ion pair was applied in asymmetric counter-anion-directed catalysis to give Diels-Alder reaction adducts with up to 53 % ee.
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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI