HPLC of Formula: 32780-06-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about A concise synthesis of anti-viral agent F-ddA, starting from (S)-dihydro-5-(hydroxymethyl)-2(3H)-furanone. Author is Choudhury, Anusuya; Jin, Fuqiang; Wang, Dengjin; Wang, Zhe; Xu, Guoyou; Nguyen, Dieu; Castoro, John; Pierce, Michael E.; Confalone, Pat N..
Anti-HIV agent β-F-ddA has been synthesized starting from readily available non-sugar, (S)-(+)-Dihydro-5-(hydroxymethyl)-2-(3H)-furanone. A highly syn-stereoselective fluorination of the hydroxy lactone I generates the key intermediate fluorolactone II in a short and concise synthetic sequence. Reduction of II followed by bromination generates the aglycon which is glycosylated to generate F-ddA by amination and deprotection. Steric bulk of the 5-protecting group has minimal effect on the steric course of glycosylation.
《A concise synthesis of anti-viral agent F-ddA, starting from (S)-dihydro-5-(hydroxymethyl)-2(3H)-furanone》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)HPLC of Formula: 32780-06-6.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI