In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, Structure-Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials, published in 2013-07-25, which mentions a compound: 1184917-16-5, Name is 4-Bromo-2,5-dichloropyridine, Molecular C5H2BrCl2N, Computed Properties of C5H2BrCl2N.
The synthesis, preclin. profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor (I; LDK378) are described. In this initial report, preliminary structure-activity relationships (SARs) are described as well as the rational design strategy employed to overcome the development deficiencies of the first generation ALK inhibitor (II; TAE684). Compound I is currently in phase 1 and phase 2 clin. trials with substantial antitumor activity being observed in ALK-pos. cancer patients.
This literature about this compound(1184917-16-5)Computed Properties of C5H2BrCl2Nhas given us a lot of inspiration, and I hope that the research on this compound(4-Bromo-2,5-dichloropyridine) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI