The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-(Piperazin-1-yl)nicotinonitrile( cas:149554-29-0 ) is researched.Name: 6-(Piperazin-1-yl)nicotinonitrile.Hurth, Konstanze; Enz, Albert; Floersheim, Philipp; Gentsch, Conrad; Hoyer, Daniel; Langenegger, Daniel; Neumann, Peter; Pfaeffli, Paul; Sorg, Dieter; Swoboda, Robert; Vassout, Annick; Troxler, Thomas published the article 《SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists》 about this compound( cas:149554-29-0 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: SAR structure arylpiperazine moiety obeline somatostatin sst receptor antagonist. Let’s learn more about this compound (cas:149554-29-0).
The SAR of over 50 derivatives of octahydrobenzo[g]quinoline (obeline)-type somatostatin sst1 receptor antagonist 1 is presented, focusing on the modification of its arylpiperazine moiety. Sst1 affinities in this series cover a range of five orders of magnitude with the best derivatives displaying subnanomolar sst1 affinities and >10,000-fold selectivities over the sst2 receptor subtype as well as promising pharmacokinetic properties.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI