The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The effect of toxic pyridine-alkaloid secondary metabolites on the sunbird gut microbiome》. Authors are Gunasekaran, Mohanraj; Lalzar, Maya; Sharaby, Yehonatan; Izhaki, Ido; Halpern, Malka.The article about the compound:(S)-3-(Piperidin-2-yl)pyridinecas:494-52-0,SMILESS:C1(C=NC=CC=1)[C@@H]1CCCCN1).COA of Formula: C10H14N2. Through the article, more information about this compound (cas:494-52-0) is conveyed.
Abstract: Sunbirds feed on tobacco tree nectar which contains toxic nicotine and anabasine secondary metabolites. Our aim was to understand the effect of nicotine and anabasine on the gut microbiota composition of sunbirds. Sixteen captive sunbirds were randomly assigned to two diets: artificial nectar either with (treatment) or without (control) added nicotine and anabasine. Excreta were collected at 0, 2, 4 and 7 wk of treatment and samples were processed for bacterial culture and high-throughput amplicon sequencing of the 16S rRNA gene. The gut microbiome diversity of the treated and control birds changed differently along the seven-week experiment While the diversity decreased in the control group along the first three samplings (0, 2 and 4 wk), it increased in the treatment group. The microbiota composition analyses demonstrated that a diet with nicotine and anabasine, significantly changed the birds′ gut microbiota composition compared to the control birds. The abundance of nicotine- and anabasine- degrading bacteria in the excreta of the treated birds, was significantly higher after four and seven weeks compared to the control group. Furthermore, anal. of culturable isolates, including Lactococcus, showed that sunbirds′ gut-associated bacteria were capable of degrading nicotine and anabasine, consistent with their hypothesised role as detoxifying and nutritional symbionts.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI