The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Water of crystallization of amino acids and their salts》. Authors are Hayashi, Koichi; Nagashima, Nobuya; Hino, Tetsuo.The article about the compound:DL-Histidine monohydrochloride monohydratecas:123333-71-1,SMILESS:O=C(O)C(N)CC1=CNC=N1.[H]Cl.[H]O[H]).COA of Formula: C6H12ClN3O3. Through the article, more information about this compound (cas:123333-71-1) is conveyed.
DTA and thermogravimetry showed the following dehydration temperatures: L-alginine dihydrate 50°, L-alginine L-aspartate monohydrate 88°, L-alginine L-glutamate trihydrate 82°, L-asparagine monohydrate 75°, DL-asparagine monohydrate 75°, K L-aspartate dihydrate 45° and 128°, Na L-aspartate monohydrate 135°, L-cysteine-HCl.-H2O 50°, L-Cysteine monohydrate 83°, DL-glutamic acid monohydrate 100° Na L-glutamate monohydrate 120°, Na DL-glutamate dihydrate 100° L-hystidine-HCl.H2O 144°, DL-hystidine-HCl.H2O 100° and 144°, L-isoleucine-HCl.H2O 80°, DL-alloisoleucine-HCl.H2O 50°, Cu L-isoleucine monohydrate 73°, L-lysine-HCl.H2O 50° and 115°, L-lysine L-glutamate dihydrate 85°,L-ornithine L-aspartate monohydrate 61°, L-proline monohydrate 50°, DL-proline monohydrate 63° and 135°, L-serine monohydrate 40° and 100°, L-valine-HCl.H2O 50°, and DL-valine-HCl.H2O 50°.
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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI