Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 32780-06-6, is researched, SMILESS is O=C1O[C@H](CO)CC1, Molecular C5H8O3Journal, Article, Carbohydrate Research called Geminal alkylation in carbohydrate chemistry. Conversion of L-glutamic acid into gem-di-C-methyl carbohydrate derivatives, and synthesis of 6-chloro-9-(5,5-dimethylfuran-2-yl)purine, Author is Szarek, Walter A.; Yvas, Dolatrai M.; Chen, Lu-Yu, the main research direction is alkylation glutamic acid; furanol alkyl; nucleoside analog furanylpurine; purine furanyl nucleoside analog.Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.
Deamination-esterification of L-glutamic acid followed by reduction, benzylation, treatment with MeMgI, and hydrogenolysis over Pd/C gave the key intermediate I. Oxidation of I with NaIO4 gave the gem-di-C-methyl II. Reaction of II with 6-chloropurine, (EtO2CN:)2, and Ph2PMe in THF at room temperature gave the nucleoside analog III.
This compound((S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one)Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI