The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(p-Tolyl)-2,2:6,2-terpyridine(SMILESS: CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1,cas:89972-77-0) is researched.Formula: C5H6O2. The article 《High yield preparation of 4′-(4-bromophenyl)-2,2′:6′,2″”-terpyridine by a condensation reaction. Determination of the stereochemistry of two complex byproducts by a combination of molecular mechanics and NMR spectroscopy》 in relation to this compound, is published in Acta Chemica Scandinavica. Let’s take a look at the latest research on this compound (cas:89972-77-0).
An improved high yield synthesis of 4′-(4-bromophenyl)-2,2′:6′,2″”-terpyridine from 2-acetylpyridine (I) and 4-bromobenzaldehyde (II) has been developed, using a two-step aldol condensation. In this, the intermediate azachalcone was isolated, then reacted with N-[2-oxo-2-(2-pyridyl)ethyl]pyridinium iodide, prepared from I, using ammonium acetate both as a base and as a ring closure agent. It could also be shown that one step aldol condensation of I and II gave low yields of the desired terpyridine due to facile formation of polycondensation products. Two of these, cyclohexanes III and IV, could be isolated in moderate yields from condensation reactions. The structure and relative configuration of these compounds were determined by a comparison of observed exptl. NMR parameters with theor. values, calculated by mol. mechanics.
As far as I know, this compound(89972-77-0)Safety of 4-(p-Tolyl)-2,2:6,2-terpyridine can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI